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Transforming unstructured text into structured and meaningful forms, organized by useful category labels, is a fundamental step in text mining for downstream analysis and application. However, most existing methods for producing label…

The Clock Drawing Test (CDT) is a rapid, inexpensive, and popular neuropsychological screening tool for cognitive conditions. The Digital Clock Drawing Test (dCDT) uses novel software to analyze data from a digitizing ballpoint pen that…

Machine Learning · Statistics 2016-06-24 William Souillard-Mandar , Randall Davis , Cynthia Rudin , Rhoda Au , Dana Penney

Evidence-based medicine, the practice in which healthcare professionals refer to the best available evidence when making decisions, forms the foundation of modern healthcare. However, it relies on labour-intensive systematic reviews, where…

Computation and Language · Computer Science 2021-12-13 Jetsun Whitton , Anthony Hunter

Drug discovery frequently loses momentum when data, expertise, and tools are scattered, slowing design cycles. To shorten this loop we built a hierarchical, tool using agent framework that automates molecular optimisation. A Principal…

Machine Learning · Computer Science 2025-08-06 Atabey Ünlü , Phil Rohr , Ahmet Celebi

Data science tasks involving tabular data present complex challenges that require sophisticated problem-solving approaches. We propose AutoKaggle, a powerful and user-centric framework that assists data scientists in completing daily data…

Large Language Model (LLM)-based optimization has recently shown promise for autonomous problem solving, yet most approaches still cast LLMs as passive constraint checkers rather than proactive strategy designers, limiting their…

Artificial Intelligence · Computer Science 2026-04-06 Beidan Liu , Zhengqiu Zhu , Chen Gao , Tianle Pu , Yong Zhao , Wei Qi , Quanjun Yin

The exponential growth of data-driven systems and AI technologies has intensified the demand for high-quality web-sourced datasets. While existing datasets have proven valuable, conventional web data collection approaches face significant…

A fundamental question in applying In-Context Learning (ICL) for tabular data classification is how to determine the ideal number of demonstrations in the prompt. This work addresses this challenge by presenting an algorithm to…

Machine Learning · Computer Science 2025-06-26 Shuchu Han , Wolfgang Bruckner

Cognitive computing models offer a formal and interpretable way to characterize human's deliberation and decision-making, yet their development remains labor-intensive. In this paper, we propose NL2CA, a novel method for auto-formalizing…

Artificial Intelligence · Computer Science 2025-12-23 Zihao Deng , Yijia Li , Renrui Zhang , Peijun Ye

Large Language Models (LLMs) have shown remarkable ability in solving complex tasks, making them a promising tool for enhancing tabular learning. However, existing LLM-based methods suffer from high resource requirements, suboptimal…

Machine Learning · Computer Science 2025-05-12 Ruxue Shi , Hengrui Gu , Xu Shen , Xin Wang

A knowledge gap persists between machine learning (ML) developers (e.g., data scientists) and practitioners (e.g., clinicians), hampering the full utilization of ML for clinical data analysis. We investigated the potential of the ChatGPT…

Selecting artificial intelligence (AI) models, such as large language models (LLMs), from multiple candidates requires accurate performance estimation. This is ideally achieved through empirical evaluations involving abundant real-world…

Machine Learning · Statistics 2025-12-03 Sangwoo Park , Matteo Zecchin , Osvaldo Simeone

Many existing models for clinical trial outcome prediction are optimized using task-specific loss functions on trial phase-specific data. While this scheme may boost prediction for common diseases and drugs, it can hinder learning of…

Machine Learning · Computer Science 2025-05-27 Yiqing Zhang , Xiaozhong Liu , Fabricio Murai

Large language models (LLMs) have demonstrated remarkable capabilities across a range of text-generation tasks. However, LLMs still struggle with problems requiring multi-step decision-making and environmental feedback, such as online…

Artificial Intelligence · Computer Science 2025-02-18 Zhenfang Chen , Delin Chen , Rui Sun , Wenjun Liu , Chuang Gan

Due to increased access to clinical trial outcomes and analysis, researchers and scientists are able to iterate or improve upon relevant approaches more effectively. However, the metrics and related results of clinical trials typically do…

Computation and Language · Computer Science 2021-01-12 Shwetha Bharadwaj , Melanie Laffin

Large language models (LLMs) have shown impressive performance in general programming tasks. However, in Machine Learning Engineering (MLE) scenarios such as AutoML and Kaggle competitions, achieving high performance depends heavily on…

Artificial Intelligence · Computer Science 2025-10-10 Shangheng Du , Xiangchao Yan , Dengyang Jiang , Jiakang Yuan , Yusong Hu , Xin Li , Liang He , Bo Zhang , Lei Bai

Participant recruitment based on unstructured medical texts such as clinical notes and radiology reports has been a challenging yet important task for the cohort establishment in clinical research. Recently, Large Language Models (LLMs)…

Computation and Language · Computer Science 2023-07-24 Zihan Guan , Zihao Wu , Zhengliang Liu , Dufan Wu , Hui Ren , Quanzheng Li , Xiang Li , Ninghao Liu

Chimeric antigen receptor T-cell (CAR-T) therapy represents a paradigm shift in cancer treatment, yet development timelines of 8-12 years and clinical attrition rates exceeding 40-60% highlight critical inefficiencies in target selection,…

Quantitative Methods · Quantitative Biology 2025-11-13 Yi Ni , Liwei Zhu , Shuai Li

Large language models (LLMs) face significant challenges when processing complex rule systems, as they typically treat interdependent rules as unstructured textual data rather than as logically organized frameworks. This limitation results…

Clinical dialogue represents a complex duality requiring both the empathetic fluency of natural conversation and the rigorous precision of evidence-based medicine. While Large Language Models possess unprecedented linguistic capabilities,…

Other Quantitative Biology · Quantitative Biology 2025-12-02 Xiaoquan Zhi , Hongke Zhao , Likang Wu , Chuang Zhao , Hengshu Zhu