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We propose an imaging system and methodology for mapping soft-tissue samples in three dimensions, with micron-scale and isotropic spatial resolution, with low-concentrations as well as in the absence of heavy metal staining. We used hard…
X-ray phase-contrast imaging (XPCI) is a versatile technique with wide-ranging applications, particularly in the fields of biology and medicine. Where X-ray absorption radiography requires high density ratios for effective imaging, XPCI is…
Dark-field X-ray imaging is a novel modality which visualises scattering from unresolved microstructure. Most dark-field imaging techniques rely on crystals or structured illumination, but recent work has shown that dark-field effects are…
Multi-energy CT has long demonstrated its ability to enhance image quality with material decomposition. Yet, it has largely been limited to applications that already have high contrast. More recently, x-ray phase-contrast (XPC) imaging has…
Complex-field imaging is indispensable for numerous applications at wavelengths from X-ray to THz, with amplitude describing transmittance (or reflectivity) and phase revealing intrinsic structure of the target object. Coherent diffraction…
Recent innovations in x-ray technology (namely phase-based and energy-resolved imaging) offer unprecedented opportunities for material discrimination, however they are often used in isolation or in limited combinations. Here we show that…
Spectral and grating-based differential phase-contrast X-ray imaging are two emerging technologies that offer additional information compared with conventional attenuation-based X-ray imaging. In the case of spectral imaging,…
Medical differential phase contrast x-ray imaging (DPCI) promises improved soft-tissue contrast at lower x-ray dose. The dose strongly depends on both the angular sensitivity and on the visibility of a grating-based Talbot-Lau…
Dark-field images are formed by small-angle scattering of x-ray photons. The small-angle scattering signal is particularly sensitive to structural variations and density fluctuation on a length scale of several ten to hundred nanometers,…
X-ray phase-contrast imaging can provide greatly improved contrast over conventional absorption-based imaging for weakly absorbing samples, such as biological soft tissues and fibre composites. In this manuscript, we introduce an easy and…
Phase contrast X-ray imaging (PCXI) is an emerging imaging modality that has the potential to greatly improve radiography for medical imaging and materials analysis. PCXI makes it possible to visualise soft-tissue structures that are…
A key contribution to X-ray dark-field (XDF) is X-ray diffusion by sample structures smaller than the imaging system's spatial resolution. However, some XDF techniques report that resolvable sample edges also generate XDF. Speckle-based…
We present a multi-aperture analyser set-up for performing X-ray phase contrast imaging in planar and three-dimensional modalities. A multi-slice representation of the sample is used to establish a quantitative relation between projection…
A method for extracting the dark-field signal in propagation-based phase-contrast imaging is proposed. In the case of objects consisting predominantly of a single material, or several different materials with similar ratios of the real…
We outline some basics of imaging using both fully-coherent and partially-coherent X-ray beams, with an emphasis on phase-contrast imaging. We open with some of the basic notions of X-ray imaging, including the vacuum wave equations and the…
Obtaining 3D information from a single X-ray exposure at high-brilliance sources, such as X-ray free-electron lasers (XFELs) [1] or diffraction-limited storage rings [2], allows the study of fast dynamical processes in their native…
We develop a speckle-tracking method for x-ray phase-contrast imaging, based on the concept of geometric flow. This flow is a conserved current associated with deformation of illuminating x-ray speckles induced by passage through a sample.…
Articular cartilage is a musculoskeletal soft tissue renowned for its unique mechanical properties. Understanding both its hierarchical structure and the interplay between its constituents could shed light on the mechanical competence of…
Biological soft tissues encountered in clinical and pre-clinical imaging mainly consist of light element atoms, and their composition is nearly uniform with little density variation. Thus, x-ray attenuation imaging suffers from low image…
Recently, X-ray interferometers with more than one phase grating have been developed for differential phase contrast (DPC) imaging. In this study, a novel framework is developed to predict such interferometers' angular sensitivity responses…