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Survival Analysis (SA) constitutes the default method for time-to-event modeling due to its ability to estimate event probabilities of sparsely occurring events over time. In this work, we show how to improve the training and inference of…

Machine Learning · Computer Science 2023-12-12 Chris Solomou

This work introduces a novel framework for evaluating LLMs' capacity to balance instruction-following with critical reasoning when presented with multiple-choice questions containing no valid answers. Through systematic evaluation across…

Computation and Language · Computer Science 2025-06-03 Gracjan Góral , Emilia Wiśnios , Piotr Sankowski , Paweł Budzianowski

Alignment evaluation in machine learning has largely become evaluation of models. Influential benchmarks score model outputs under fixed inputs, such as truthfulness, instruction following, or pairwise preference, and these scores are often…

Artificial Intelligence · Computer Science 2026-05-07 Varad Vishwarupe , Nigel Shadbolt , Marina Jirotka , Ivan Flechais

Assessing model generalization under distribution shift is essential for real-world deployment, particularly when labeled test data is unavailable. This paper presents a unified and practical framework for unsupervised model evaluation and…

Machine Learning · Computer Science 2025-10-06 Weijian Deng , Weijie Tu , Ibrahim Radwan , Mohammad Abu Alsheikh , Stephen Gould , Liang Zheng

We consider linear transformation models applied to right censored survival data with a change-point based on a covariate threshold. We establish consistency and weak convergence of the nonparametric maximum lieklihood estimators. The…

Statistics Theory · Mathematics 2007-06-13 Michael R. Kosorok , Rui Song

Assuming some regression model, it is common to study the conditional distribution of survival given covariates. Here, we consider the impact of further conditioning, specifically conditioning on a marginal survival function, known or…

Applications · Statistics 2016-10-11 Roxane Duroux , Cécile Chauvel , John O'Quigley

In this paper, we argue that the prevailing approach to training and evaluating machine learning models often fails to consider their real-world application within organizational or societal contexts, where they are intended to create…

Machine Learning · Computer Science 2025-04-24 Burcu Sayin , Jie Yang , Xinyue Chen , Andrea Passerini , Fabio Casati

Interpreting critical variables involved in complex biological processes related to survival time can help understand prediction from survival models, evaluate treatment efficacy, and develop new therapies for patients. Currently, the…

Machine Learning · Computer Science 2022-10-03 Xinxing Wu , Chong Peng , Richard Charnigo , Qiang Cheng

Two-step estimators often called upon to fit censored regression models in many areas of science and engineering. Since censoring incurs a bias in the naive least-squares fit, a two-step estimator first estimates the bias and then fits a…

Methodology · Statistics 2014-03-17 Yuekai Sun , Jonathan E. Taylor

Synthetic control (SC) methods have gained rapid popularity in economics recently, where they have been applied in the context of inferring the effects of treatments on standard continuous outcomes assuming linear input-output relations. In…

Methodology · Statistics 2024-02-19 Alicia Curth , Hoifung Poon , Aditya V. Nori , Javier González

In survival analysis it often happens that some subjects under study do not experience the event of interest; they are considered to be `cured'. The population is thus a mixture of two subpopulations: the one of cured subjects, and the one…

Statistics Theory · Mathematics 2017-01-16 Valentin Patilea , Ingrid Van Keilegom

Clinical researchers often select among and evaluate risk prediction models using standard machine learning metrics based on confusion matrices. However, if these models are used to allocate interventions to patients, standard metrics…

Machine Learning · Statistics 2020-06-03 Alejandro Schuler , Aashish Bhardwaj , Vincent Liu

In the era of increasingly complex AI models for time series forecasting, progress is often measured by marginal improvements on benchmark leaderboards. However, this approach suffers from a fundamental flaw: standard evaluation metrics…

Machine Learning · Computer Science 2026-05-28 Wanjin Feng , Yuan Yuan , Jingtao Ding , Yong Li

Model-free time-to-event regression under confounding presents challenges due to biases introduced by causal and censoring sampling mechanisms. This phenomenology poses problems for classical non-parametric estimators like Beran's or the…

Statistics Theory · Mathematics 2025-02-28 Carlos García-Meixide , Marcos Matabuena

Risk prediction models are widely used to guide real-world decision-making in areas such as healthcare and economics, and they also play a key role in estimating nuisance parameters in semiparametric inference. The super learner is a…

Methodology · Statistics 2025-09-05 Anders Munch , Thomas A. Gerds

Harrel's concordance index is a commonly used discrimination metric for survival models, particularly for models where the relative ordering of the risk of individuals is time-independent, such as the proportional hazards model. There are…

Methodology · Statistics 2023-06-27 A. Gandy , T. J. Matcham

In observational studies of survival time featuring a binary time-dependent treatment, the hazard ratio (an instantaneous measure) is often used to represent the treatment effect. However, investigators are often more interested in the…

Methodology · Statistics 2020-05-21 Yun Li , Douglas E. Schaubel , Kevin He

Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

The C-Index measures the discrimination performance of survival prediction models. C-Index scores are often well below the upperbound of 1 that represents perfect prediction and closer to 0.5 as achieved by random prediction. Our first…

Applications · Statistics 2025-06-09 Felipe Simon , Francisco Perez-Galarce , Joris van de Klundert

We present a conformal inference method for constructing lower prediction bounds for survival times from right-censored data, extending recent approaches designed for more restrictive type-I censoring scenarios. The proposed method imputes…

Methodology · Statistics 2025-05-26 Matteo Sesia , Vladimir Svetnik
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