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Deep learning-based AI models have been extensively applied in genomics, achieving remarkable success across diverse applications. As these models gain prominence, there exists an urgent need for interpretability methods to establish…

Genomics · Quantitative Biology 2025-05-16 Chenyu Wang , Chaoying Zuo , Zihan Su , Yuhang Xing , Lu Li , Maojun Wang , Zeyu Zhang

Structured prediction involves learning to predict complex structures rather than simple scalar values. The main challenge arises from the non-Euclidean nature of the output space, which generally requires relaxing the problem formulation.…

Machine Learning · Statistics 2024-11-19 Junjie Yang , Matthieu Labeau , Florence d'Alché-Buc

Familiarity with a simulation platform can seduce modellers into accepting untested assumptions for convenience of implementation. These assumptions may have consequences greater than commonly suspected, and it is important that modellers…

Quantitative Methods · Quantitative Biology 2014-02-28 Jerome K Vanclay

Graph Neural Networks (GNNs) have become a powerful tool for modeling and analyzing data with graph structures. The wide adoption in numerous applications underscores the value of these models. However, the complexity of these methods often…

Artificial Intelligence · Computer Science 2025-12-10 Tien Cuong Bui

Prototypical part learning is emerging as a promising approach for making semantic segmentation interpretable. The model selects real patches seen during training as prototypes and constructs the dense prediction map based on the similarity…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Hugo Porta , Emanuele Dalsasso , Diego Marcos , Devis Tuia

Learning from longitudinal electronic health records is limited if it does not capture the temporal trajectories of the patient's state in a clinical setting. Graph models allow us to capture the hidden dependencies of the multivariate…

Machine Learning · Computer Science 2025-03-31 Munib Mesinovic , Soheila Molaei , Peter Watkinson , Tingting Zhu

Though linguistic knowledge emerges during large-scale language model pretraining, recent work attempt to explicitly incorporate human-defined linguistic priors into task-specific fine-tuning. Infusing language models with syntactic or…

Computation and Language · Computer Science 2022-10-25 Changlong Yu , Tianyi Xiao , Lingpeng Kong , Yangqiu Song , Wilfred Ng

When we deploy machine learning models in high-stakes medical settings, we must ensure these models make accurate predictions that are consistent with known medical science. Inherently interpretable networks address this need by explaining…

Computer Vision and Pattern Recognition · Computer Science 2021-10-06 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

The lack of interpretability remains a barrier to the adoption of deep neural networks. Recently, tree regularization has been proposed to encourage deep neural networks to resemble compact, axis-aligned decision trees without significant…

Machine Learning · Computer Science 2020-03-17 Mike Wu , Sonali Parbhoo , Michael Hughes , Ryan Kindle , Leo Celi , Maurizio Zazzi , Volker Roth , Finale Doshi-Velez

The interpretability of models has become a crucial issue in Machine Learning because of algorithmic decisions' growing impact on real-world applications. Tree ensemble methods, such as Random Forests or XgBoost, are powerful learning tools…

Optimization and Control · Mathematics 2024-01-19 Giulia Di Teodoro , Marta Monaci , Laura Palagi

In the context of structural health monitoring (SHM), the selection and extraction of damage-sensitive features from raw sensor recordings represent a critical step towards solving the inverse problem underlying the identification of…

Computational Engineering, Finance, and Science · Computer Science 2025-12-03 Matteo Torzoni , Andrea Manzoni , Stefano Mariani

Originally designed to model text, topic modeling has become a powerful tool for uncovering latent structure in domains including medicine, finance, and vision. The goals for the model vary depending on the application: in some cases, the…

Machine Learning · Statistics 2014-11-24 Finale Doshi-Velez , Byron Wallace , Ryan Adams

Interpretable brain network models for disease prediction are of great value for the advancement of neuroscience. GNNs are promising to model complicated network data, but they are prone to overfitting and suffer from poor interpretability,…

Machine Learning · Computer Science 2021-07-13 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

Epidemic outcomes have a complex interplay with human behavior and beliefs. Most of the forecasting literature has focused on the task of predicting epidemic signals using simple mechanistic models or black-box models, such as deep…

Machine Learning · Computer Science 2025-12-02 Mulin Tian , Ajitesh Srivastava

The Distributional Random Forest (DRF) is a recently introduced Random Forest algorithm to estimate multivariate conditional distributions. Due to its general estimation procedure, it can be employed to estimate a wide range of targets such…

Statistics Theory · Mathematics 2023-12-20 Jeffrey Näf , Corinne Emmenegger , Peter Bühlmann , Nicolai Meinshausen

We present Collaborative Trees, a novel tree model designed for regression prediction, along with its bagging version, which aims to analyze complex statistical associations between features and uncover potential patterns inherent in the…

Methodology · Statistics 2024-05-21 Chien-Ming Chi

With the advent of highly predictive but opaque deep learning models, it has become more important than ever to understand and explain the predictions of such models. Existing approaches define interpretability as the inverse of complexity…

With the growing adoption of AI-based systems across everyday life, the need to understand their decision-making mechanisms is correspondingly increasing. The level at which we can trust the statistical inferences made from AI-based…

Machine Learning · Statistics 2024-04-15 Adam Spannaus , Heidi A. Hanson , Lynne Penberthy , Georgia Tourassi

Intrinsic interpretability of graph neural networks (GNNs) is to find a small subset of the input graph's features -- rationale -- which guides the model prediction. Unfortunately, the leading rationalization models often rely on data…

Machine Learning · Computer Science 2022-02-01 Ying-Xin Wu , Xiang Wang , An Zhang , Xiangnan He , Tat-Seng Chua

Interpretable machine learning has become a very active area of research due to the rising popularity of machine learning algorithms and their inherently challenging interpretability. Most work in this area has been focused on the…

Machine Learning · Statistics 2023-11-09 Quay Au , Julia Herbinger , Clemens Stachl , Bernd Bischl , Giuseppe Casalicchio