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The success of Multimodal Large Language Models (MLLMs) in the medical auxiliary field shows great potential, allowing patients to engage in conversations using physiological signal data. However, general MLLMs perform poorly in cardiac…

Signal Processing · Electrical Eng. & Systems 2025-04-17 Yubao Zhao , Jiaju Kang , Tian Zhang , Puyu Han , Tong Chen

Electrocardiogram (ECG), a non-invasive and affordable tool for cardiac monitoring, is highly sensitive in detecting acute heart attacks. However, due to the lengthy nature of ECG recordings, numerous machine learning methods have been…

Signal Processing · Electrical Eng. & Systems 2025-03-04 Yue Wang , Xu Cao , Yaojun Hu , Haochao Ying , Hongxia Xu , Ruijia Wu , James Matthew Rehg , Jimeng Sun , Jian Wu , Jintai Chen

Electrocardiogram (ECG) interpretation requires specialized expertise, often involving synthesizing insights from ECG signals with complex clinical queries posed in natural language. The scarcity of labeled ECG data coupled with the diverse…

Machine Learning · Computer Science 2025-05-09 Jialu Tang , Tong Xia , Yuan Lu , Cecilia Mascolo , Aaqib Saeed

Multimodal large language models (MLLMs) are increasingly being applied in the medical field, particularly in medical imaging. However, developing MLLMs for ECG signals, which are crucial in clinical settings, has been a significant…

Computation and Language · Computer Science 2024-11-25 Haitao Li , Ziyu Li , Yiheng Mao , Ziyi Liu , Zhoujian Sun , Zhengxing Huang

Large Language Models (LLMs) hold significant promise for electrocardiogram (ECG) analysis, yet challenges remain regarding transferability, time-scale information learning, and interpretability. Current methods suffer from model-specific…

Artificial Intelligence · Computer Science 2025-09-17 Yong Xia , Jingxuan Li , YeTeng Sun , Jiarui Bu

Electrocardiogram (ECG) is the primary non-invasive diagnostic tool for monitoring cardiac conditions and is crucial in assisting clinicians. Recent studies have concentrated on classifying cardiac conditions using ECG data but have…

Computation and Language · Computer Science 2025-07-09 Zhongwei Wan , Che Liu , Xin Wang , Chaofan Tao , Hui Shen , Jing Xiong , Rossella Arcucci , Huaxiu Yao , Mi Zhang

Electrocardiography (ECG) plays a central role in cardiovascular diagnostics, yet existing automated approaches often struggle to generalize across clinical tasks and offer limited support for open-ended reasoning. We present HeartLLM, a…

Artificial Intelligence · Computer Science 2026-01-27 Jinning Yang , Wenjie Sun , Wen Shi

While Multimodal Large Language Models (MLLMs) show promising performance in automated electrocardiogram interpretation, it remains unclear whether they genuinely perform actual step-by-step reasoning or just rely on superficial visual…

Machine Learning · Computer Science 2026-03-17 Jungwoo Oh , Hyunseung Chung , Junhee Lee , Min-Gyu Kim , Hangyul Yoon , Ki Seong Lee , Youngchae Lee , Muhan Yeo , Edward Choi

Electrocardiography (ECG) serves as an indispensable diagnostic tool in clinical practice, yet existing multimodal large language models (MLLMs) remain unreliable for ECG interpretation, often producing plausible but clinically incorrect…

Computation and Language · Computer Science 2026-05-26 Jiarui Jin , Haoyu Wang , Xingliang Wu , Xiaocheng Fang , Xiang Lan , Zihan Wang , Deyun Zhang , Bo Liu , Yingying Zhang , Xian Wu , Hongyan Li , Shenda Hong

Recent advances have increasingly applied large language models (LLMs) to electrocardiogram (ECG) interpretation, giving rise to Electrocardiogram-Language Models (ELMs). Conditioned on an ECG and a textual query, an ELM autoregressively…

Artificial Intelligence · Computer Science 2025-05-27 William Han , Chaojing Duan , Zhepeng Cen , Yihang Yao , Xiaoyu Song , Atharva Mhaskar , Dylan Leong , Michael A. Rosenberg , Emerson Liu , Ding Zhao

Automated interpretation of electrocardiograms (ECG) has garnered significant attention with the advancements in machine learning methodologies. Despite the growing interest, most current studies focus solely on classification or regression…

Signal Processing · Electrical Eng. & Systems 2023-11-07 Jielin Qiu , Jiacheng Zhu , Shiqi Liu , William Han , Jingqi Zhang , Chaojing Duan , Michael Rosenberg , Emerson Liu , Douglas Weber , Ding Zhao

Electrocardiography (ECG) offers critical cardiovascular insights, such as identifying arrhythmias and myocardial ischemia, but enabling automated systems to answer complex clinical questions directly from ECG signals (ECG-QA) remains a…

Signal Processing · Electrical Eng. & Systems 2025-05-13 Hung Manh Pham , Jialu Tang , Aaqib Saeed , Dong Ma

The electrocardiogram (ECG) is an essential non-invasive diagnostic tool for assessing cardiac conditions. Existing automatic interpretation methods suffer from limited generalizability, focusing on a narrow range of cardiac conditions, and…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Ruoqi Liu , Yuelin Bai , Xiang Yue , Ping Zhang

Electrocardiogram (ECG) monitoring is one of the most powerful technique of cardiovascular disease (CVD) early identification, and the introduction of intelligent wearable ECG devices has enabled daily monitoring. However, due to the need…

Signal Processing · Electrical Eng. & Systems 2024-03-08 Hongxiang Gao , Xingyao Wang , Zhenghua Chen , Min Wu , Jianqing Li , Chengyu Liu

Scalable and generalizable analysis of brain activity is essential for advancing both clinical diagnostics and cognitive research. Electroencephalography (EEG), a non-invasive modality with high temporal resolution, has been widely used for…

Machine Learning · Computer Science 2025-12-01 Sha Zhao , Mingyi Peng , Haiteng Jiang , Tao Li , Shijian Li , Gang Pan

Electroencephalography (EEG) interpretation using multimodal large language models (MLLMs) offers a novel approach for analyzing brain signals. However, the complex nature of brain activity introduces critical challenges: EEG signals…

Signal Processing · Electrical Eng. & Systems 2025-10-02 Ziyi Zeng , Zhenyang Cai , Yixi Cai , Xidong Wang , Junying Chen , Rongsheng Wang , Yipeng Liu , Siqi Cai , Benyou Wang , Zhiguo Zhang , Haizhou Li

Interpreting electrocardiograms (ECGs) and generating comprehensive reports remain challenging tasks in cardiology, often requiring specialized expertise and significant time investment. To address these critical issues, we propose…

Machine Learning · Computer Science 2024-09-16 Jialu Tang , Tong Xia , Yuan Lu , Cecilia Mascolo , Aaqib Saeed

While recent multimodal large language models (MLLMs) have advanced automated ECG interpretation, they still face two key limitations: (1) insufficient multimodal synergy between time series signals and visual ECG representations, and (2)…

Computation and Language · Computer Science 2025-10-21 Xiang Lan , Feng Wu , Kai He , Qinghao Zhao , Shenda Hong , Mengling Feng

Recent advances in Multimodal Large Language Models have rapidly expanded to electrocardiograms, focusing on classification, report generation, and single-turn QA tasks. However, these models fall short in real-world scenarios, lacking…

Artificial Intelligence · Computer Science 2026-01-29 Hyunseung Chung , Jungwoo Oh , Daeun Kyung , Jiho Kim , Yeonsu Kwon , Min-Gyu Kim , Edward Choi

Electrocardiogram (ECG) foundation models represent a paradigm shift from task-specific pipelines to generalizable architectures pre-trained on large-scale unlabeled waveform data. This survey presents a unified and deployment-aware review…

Signal Processing · Electrical Eng. & Systems 2026-04-06 Mudassir Hasan Khan , Ahmad Nayfeh , Mudassir Masood , Ali Ahmad Al-Shaikhi , Muhammad Mahboob Ur Rahman , Tareq Y. Al-Naffouri
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