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Background: Alignment of biological sequences such as DNA, RNA or proteins is one of the most widely used tools in computational bioscience. All existing alignment algorithms rely on heuristic scoring schemes based on biological expertise.…

Genomics · Quantitative Biology 2008-10-27 Orion Penner , Peter Grassberger , Maya Paczuski

Deep neural networks can memorize corrupted labels, making data quality critical for model performance, yet real-world datasets are frequently compromised by both label noise and input noise. This paper proposes a mutual information-based…

Machine Learning · Computer Science 2025-08-12 Jinghan Yang , Jiayu Weng

Deep learning based physical layer design, i.e., using dense neural networks as encoders and decoders, has received considerable interest recently. However, while such an approach is naturally training data-driven, actions of the wireless…

Information Theory · Computer Science 2020-06-30 Rick Fritschek , Rafael F. Schaefer , Gerhard Wunder

End-to-end deep learning for communication systems, i.e., systems whose encoder and decoder are learned, has attracted significant interest recently, due to its performance which comes close to well-developed classical encoder-decoder…

Information Theory · Computer Science 2019-03-12 Rick Fritschek , Rafael F. Schaefer , Gerhard Wunder

Missing data present challenges in data analysis. Naive analyses such as complete-case and available-case analysis may introduce bias and loss of efficiency, and produce unreliable results. Multiple imputation (MI) is one of the most widely…

Methodology · Statistics 2019-05-15 Domonique W. Hodge , Sandra E. Safo , Qi Long

This paper demonstrates dynamic hyper-parameter setting, for deep neural network training, using Mutual Information (MI). The specific hyper-parameter studied in this paper is the learning rate. MI between the output layer and true outcomes…

Machine Learning · Computer Science 2018-06-27 Shrihari Vasudevan

Widely used methods for analyzing missing data can be biased in small samples. To understand these biases, we evaluate in detail the situation where a small univariate normal sample, with values missing at random, is analyzed using either…

Statistics Theory · Mathematics 2017-03-27 Paul T. von Hippel

Estimating the entropy of a discrete random variable is a fundamental problem in information theory and related fields. This problem has many applications in various domains, including machine learning, statistics and data compression. Over…

Information Theory · Computer Science 2020-12-22 Yuval Shalev , Amichai Painsky , Irad Ben-Gal

Mechanistic Interpretability (MI) aims to reverse-engineer model behaviors by identifying functional sub-networks. Yet, the scientific validity of these findings depends on their stability. In this work, we argue that circuit discovery is…

Machine Learning · Computer Science 2026-02-04 Maxime Méloux , François Portet , Maxime Peyrard

Data from spectrophotometers form vectors of a large number of exploitable variables. Building quantitative models using these variables most often requires using a smaller set of variables than the initial one. Indeed, a too large number…

Machine Learning · Computer Science 2007-09-26 Fabrice Rossi , Amaury Lendasse , Damien François , Vincent Wertz , Michel Verleysen

We study differentially private mean estimation in a high-dimensional setting. Existing differential privacy techniques applied to large dimensions lead to computationally intractable problems or estimators with excessive privacy loss.…

Machine Learning · Computer Science 2020-07-23 Aditya Dhar , Jason Huang

With the success of self-supervised representations, researchers seek a better understanding of the information encapsulated within a representation. Among various interpretability methods, we focus on classification-based linear probing.…

Information Theory · Computer Science 2023-12-18 Kwanghee Choi , Jee-weon Jung , Shinji Watanabe

High-dimensional statistical inference with general estimating equations are challenging and remain less explored. In this paper, we study two problems in the area: confidence set estimation for multiple components of the model parameters,…

Methodology · Statistics 2021-04-28 Jinyuan Chang , Song Xi Chen , Cheng Yong Tang , Tong Tong Wu

Mutual information (MI) is a principled and widely used objective for robotic information gathering (RIG), providing strong theoretical guarantees for sensor placement (SP) and informative path planning (IPP). However, its high…

Robotics · Computer Science 2026-02-16 Kalvik Jakkala , Jason O'Kane , Srinivas Akella

Estimation of mutual information between random variables has become crucial in a range of fields, from physics to neuroscience to finance. Estimating information accurately over a wide range of conditions relies on the development of…

Methodology · Statistics 2018-11-14 Houman Safaai , Arno Onken , Christopher D. Harvey , Stefano Panzeri

Mutual information provides a powerful, general-purpose metric for quantifying the amount of shared information between variables. Estimating normalized mutual information using a k-Nearest Neighbor (k-NN) based approach involves the…

Information Theory · Computer Science 2025-07-10 Marko Tuononen , Ville Hautamäki

Robust statistics aims to compute quantities to represent data where a fraction of it may be arbitrarily corrupted. The most essential statistic is the mean, and in recent years, there has been a flurry of theoretical advancement for…

Machine Learning · Statistics 2025-02-18 Cullen Anderson , Jeff M. Phillips

We define Persistent Mutual Information (PMI) as the Mutual (Shannon) Information between the past history of a system and its evolution significantly later in the future. This quantifies how much past observations enable long term…

Adaptation and Self-Organizing Systems · Physics 2015-03-13 R. C. Ball , M. Diakonova , R. S. MacKay

In the setting where we ask participants multiple similar possibly subjective multi-choice questions (e.g. Do you like Bulbasaur? Y/N; do you like Squirtle? Y/N), peer prediction aims to design mechanisms that encourage honest feedback…

Computer Science and Game Theory · Computer Science 2021-11-09 Yuqing Kong

The selection of features that are relevant for a prediction or classification problem is an important problem in many domains involving high-dimensional data. Selecting features helps fighting the curse of dimensionality, improving the…

Machine Learning · Computer Science 2009-09-04 Michel Verleysen , Fabrice Rossi , Damien François
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