Related papers: Modelling bulk mechanical effects in a planar cell…
The effect of structural constriction on molecular mobility is investigated by broadband dielectric spectroscopy (BDS) within three types of molecular arrangements: monomers, oligomers and self-assembled monolayers (SAMs). While disordered…
We theoretically investigate the dynamics of a floating lipid bilayer membrane coupled with a two-dimensional cytoskeleton network, taking into explicitly account the intermonolayer friction, the discrete lattice structure of the…
We study the phenomenon of migration of the small molecular weight component of a binary polymer mixture to the free surface using mean field and self-consistent field theories. By proposing a free energy functional that incorporates…
Systems in which particles can self-assemble into mono- or bilayers can form variety of stable and metastable structures on a nanometer length scale. For this reason confinement has a particularly strong effect on such systems. We discuss…
Based on symmetry consideration of migration and shape deformations, we formulate phenomenologically the dynamics of cell crawling in two dimensions. Forces are introduced to change the cell shape. The shape deformations induce migration of…
We study the stress distribution profiles and the height and thickness fluctuations of lipid membranes in the tilted gel state by Monte Carlo simulations of a generic coarse-grained model for lipid membranes, which reproduces many known…
Soft elastic sheets resting on rigid surfaces develop wrinkles, rucks, and folds due to the combined influence of elasticity, gravity, and contact interactions. Despite their ubiquity, the principles governing their morphology and…
We study how the encasement of a growing elastic bulk within a possibly differently growing elastic coat may induce mechanical instabilities in the equilibrium shape of the combined body. The inhomogeneities induced in an incompressible…
Morphogenesis, tissue regeneration and cancer invasion involve transitions in tissue morphology. These transitions, caused by collective cell migration (CCM), have been interpreted as active wetting/de-wetting transitions. This phenomenon…
In this paper, we present a 2D numerical model developed to simulate the dynamics of soft, deformable particles. To accommodate significant particle deformations, the particle surface is represented as a narrow shell composed of mass points…
Cells exert traction forces on compliant substrates and can induce surface instabilities that appear as characteristic wrinkling patterns. Here, we develop a mechanical description of cell-induced wrinkling on soft substrates using a thin…
We theoretically investigate the relaxation dynamics of a nearly-flat binary lipid bilayer membrane by taking into account the membrane tension, hydrodynamics of the surrounding fluid, inter-monolayer friction and mutual diffusion in each…
Living cells establish long-range orientational order through collective alignment, giving rise to topological defects whose functional relevance is increasingly recognized in tissue organization and morphogenesis. Engineered topographical…
Tuning of active prestress e.g. through activity of molecular motors constitutes a powerful cellular tool to adjust cellular stiffness through nonlinear material properties. Understanding this tool is an important prerequisite for our…
Cell shape is fundamental in biology. The average cell shape can influence crucial biological functions, such as cell fate and division orientation. But cell-to-cell shape variability is often regarded as noise. In contrast, recent works…
This work examines the mechanical behavior of three-layer plates with a tetrachiral honeycomb core and solid face layers under static bending conditions. The influence of discretization, relative density, and thickness of the honeycomb core…
We discuss the plastic behavior of an amorphous matrix reinforced by hard particles. A mesoscopic depinning-like model accounting for Eshelby elastic interactions is implemented. Only the effect of a plastic disorder is considered.…
Cells exhibit qualitatively different behaviors on substrates with different rigidities. The fact that cells are more polarized on the stiffer substrate motivates us to construct a two-dimensional cell with the distribution of focal…
The effect of strong disorder on chiral-symmetric 3-dimensional lattice models is investigated via analytical and numerical methods. The phase diagrams of the models are computed using the non-commutative winding number, as functions of…
Using a mean field approach and simulation, we study the non-linear mechanical response of the vertex model (VM) of biological tissue under compression and dilation. The VM is known to exhibit a transition between rigid and fluid-like, or…