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Recent work has shown potential in using Mixed Integer Programming (MIP) solvers to optimize certain aspects of neural networks (NNs). However the intriguing approach of training NNs with MIP solvers is under-explored.…

Machine Learning · Computer Science 2023-04-03 Tómas Thorbjarnarson , Neil Yorke-Smith

The new era of artificial intelligence demands large-scale ultrafast hardware for machine learning. Optical artificial neural networks process classical and quantum information at the speed of light, and are compatible with silicon…

Medical Physics · Physics 2018-12-24 D. Pierangeli , V. Palmieri , G. Marcucci , C. Moriconi , G. Perini , M. De Spirito , M. Papi , C. Conti

Language models (LMs) built upon deep neural networks (DNNs) have recently demonstrated breakthrough effectiveness in software engineering tasks such as code generation, completion, and repair. This has paved the way for the emergence of…

Software Engineering · Computer Science 2025-01-06 Jingzhi Gong , Vardan Voskanyan , Paul Brookes , Fan Wu , Wei Jie , Jie Xu , Rafail Giavrimis , Mike Basios , Leslie Kanthan , Zheng Wang

Humans can often quickly and efficiently solve complex new learning tasks given only a small set of examples. In contrast, modern artificially intelligent systems often require thousands or millions of observations in order to solve even…

Machine Learning · Computer Science 2025-05-08 Christian Raymond

Motivation: MicroRNAs (miRNAs) play pivotal roles in gene expression regulation by binding to target sites of messenger RNAs (mRNAs). While identifying functional targets of miRNAs is of utmost importance, their prediction remains a great…

Genomics · Quantitative Biology 2021-10-14 Seonwoo Min , Byunghan Lee , Sungroh Yoon

Machine Learning (ML) applications on healthcare can have a great impact on people's lives helping deliver better and timely treatment to those in need. At the same time, medical data is usually big and sparse requiring important…

Machine Learning · Computer Science 2018-12-27 Dianbo Liu , Nestor Sepulveda , Ming Zheng

While RNA technologies hold immense therapeutic potential in a range of applications from vaccination to gene editing, the broad implementation of these technologies is hindered by the challenge of delivering these agents effectively. Lipid…

Biomolecules · Quantitative Biology 2023-08-30 Daisy Yi Ding , Yuhui Zhang , Yuan Jia , Jiuzhi Sun

Deep learning for distribution grid optimization can be advocated as a promising solution for near-optimal yet timely inverter dispatch. The principle is to train a deep neural network (DNN) to predict the solutions of an optimal power flow…

Optimization and Control · Mathematics 2020-07-09 Manish K. Singh , Sarthak Gupta , Vassilis Kekatos , Guido Cavraro , Andrey Bernstein

Protein structure prediction is a critical and longstanding challenge in biology, garnering widespread interest due to its significance in understanding biological processes. A particular area of focus is the prediction of missing loops in…

Predicting the secondary structure of RNA is a core challenge in computational biology, essential for understanding molecular function and designing novel therapeutics. The field has evolved from foundational but accuracy-limited…

Biomolecules · Quantitative Biology 2026-05-20 Giuseppe Sacco , Giovanni Bussi , Guido Sanguinetti

Sequential decision making, commonly formalized as optimization of a Markov Decision Process, is a key challenge in artificial intelligence. Two successful approaches to MDP optimization are reinforcement learning and planning, which both…

Machine Learning · Computer Science 2022-04-01 Thomas M. Moerland , Joost Broekens , Aske Plaat , Catholijn M. Jonker

Deep learning methods are widely applied in digital pathology to address clinical challenges such as prognosis and diagnosis. As one of the most recent applications, deep models have also been used to extract molecular features from whole…

Image and Video Processing · Electrical Eng. & Systems 2022-03-29 Amir Safarpoor , Jason D. Hipp , H. R. Tizhoosh

Sparsity is a highly desired feature in deep neural networks (DNNs) since it ensures numerical efficiency, improves the interpretability of models (due to the smaller number of relevant features), and robustness. For linear models, it is…

Machine Learning · Computer Science 2024-04-01 Augustina C. Amakor , Konstantin Sonntag , Sebastian Peitz

This paper addresses supervised deep metric learning for open-set image retrieval, focusing on three key aspects: the loss function, mixup regularization, and model initialization. In deep metric learning, optimizing the retrieval…

Computer Vision and Pattern Recognition · Computer Science 2024-12-18 Yash Patel , Giorgos Tolias , Jiri Matas

The compression of deep neural networks (DNNs) to reduce inference cost becomes increasingly important to meet realistic deployment requirements of various applications. There have been a significant amount of work regarding network…

Machine Learning · Computer Science 2020-11-12 Tianyi Chen , Bo Ji , Yixin Shi , Tianyu Ding , Biyi Fang , Sheng Yi , Xiao Tu

Optimization-based solvers play a central role in a wide range of signal processing and communication tasks. However, their applicability in latency-sensitive systems is limited by the sequential nature of iterative methods and the high…

Signal Processing · Electrical Eng. & Systems 2026-03-12 Dvir Avrahami , Amit Milstein , Caroline Chaux , Tirza Routtenberg , Nir Shlezinger

We introduce a learning-based framework to optimize tensor programs for deep learning workloads. Efficient implementations of tensor operators, such as matrix multiplication and high dimensional convolution, are key enablers of effective…

Machine Learning · Computer Science 2019-01-10 Tianqi Chen , Lianmin Zheng , Eddie Yan , Ziheng Jiang , Thierry Moreau , Luis Ceze , Carlos Guestrin , Arvind Krishnamurthy

Machine learning (ML) has revolutionized medical prognostics by integrating advanced algorithms with clinical data to enhance disease prediction, risk assessment, and patient outcome forecasting. This comprehensive review critically…

Machine Learning · Computer Science 2024-08-06 Michael Fascia

MOTIVATION: Proteins fold into complex structures that are crucial for their biological functions. Experimental determination of protein structures is costly and therefore limited to a small fraction of all known proteins. Hence, different…

Biomolecules · Quantitative Biology 2018-04-18 David Menéndez Hurtado , Karolis Uziela , Arne Elofsson

Magnetic resonance imaging (MRI) is a crucial medical imaging modality. However, long acquisition times remain a significant challenge, leading to increased costs, and reduced patient comfort. Recent studies have shown the potential of…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Amirmohammad Shamaei , Alexander Stebner , Salome , Bosshart , Johanna Ospel , Gouri Ginde , Mariana Bento , Roberto Souza