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Diffusion models are widely recognized for generating high-quality and diverse images, but their poor real-time performance has led to numerous acceleration works, primarily focusing on UNet-based structures. With the more successful…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Pengtao Chen , Mingzhu Shen , Peng Ye , Jianjian Cao , Chongjun Tu , Christos-Savvas Bouganis , Yiren Zhao , Tao Chen

We introduce a novel resampling criterion using lift scores, for improving compositional generation in diffusion models. By leveraging the lift scores, we evaluate whether generated samples align with each single condition and then compose…

Machine Learning · Computer Science 2025-05-27 Chenning Yu , Sicun Gao

Score-based diffusion models learn to reverse a stochastic differential equation that maps data to noise. However, for complex tasks, numerical error can compound and result in highly unnatural samples. Previous work mitigates this drift…

Machine Learning · Statistics 2023-06-12 Aaron Lou , Stefano Ermon

Diffusion models have emerged as a powerful paradigm for generation, obtaining strong performance in various continuous domains. However, applying continuous diffusion models to natural language remains challenging due to its discrete…

Computation and Language · Computer Science 2024-02-22 Rabeeh Karimi Mahabadi , Hamish Ivison , Jaesung Tae , James Henderson , Iz Beltagy , Matthew E. Peters , Arman Cohan

Retrosynthesis prediction is a fundamental problem in organic synthesis, where the task is to identify precursor molecules that can be used to synthesize a target molecule. A key consideration in building neural models for this task is…

Machine Learning · Computer Science 2021-06-07 Vignesh Ram Somnath , Charlotte Bunne , Connor W. Coley , Andreas Krause , Regina Barzilay

Text-conditioned image generation models have recently shown immense qualitative success using denoising diffusion processes. However, unlike discriminative vision-and-language models, it is a non-trivial task to subject these…

Computer Vision and Pattern Recognition · Computer Science 2023-11-06 Benno Krojer , Elinor Poole-Dayan , Vikram Voleti , Christopher Pal , Siva Reddy

Retrosynthesis is a problem to infer reactant compounds to synthesize a given product compound through chemical reactions. Recent studies on retrosynthesis focus on proposing more sophisticated prediction models, but the dataset to feed the…

Machine Learning · Computer Science 2020-10-05 Katsuhiko Ishiguro , Kazuya Ujihara , Ryohto Sawada , Hirotaka Akita , Masaaki Kotera

Organic synthesis is one of the key stumbling blocks in medicinal chemistry. A necessary yet unsolved step in planning synthesis is solving the forward problem: given reactants and reagents, predict the products. Similar to other work, we…

Chemical Physics · Physics 2019-09-13 Philippe Schwaller , Teodoro Laino , Théophile Gaudin , Peter Bolgar , Costas Bekas , Alpha A Lee

We present a novel way to predict molecular conformers through a simple formulation that sidesteps many of the heuristics of prior works and achieves state of the art results by using the advantages of scale. By training a diffusion…

Chemical Physics · Physics 2024-05-13 Yuyang Wang , Ahmed A. Elhag , Navdeep Jaitly , Joshua M. Susskind , Miguel Angel Bautista

Retrosynthesis is essential for designing synthetic pathways for complex molecules and can be revolutionized by AI to automate and accelerate chemical synthesis planning for drug discovery and materials science. Here, we propose a…

Chemical Physics · Physics 2024-12-02 Seongeun Yun , Won Bo Lee

Incremental brain tumor segmentation is critical for models that must adapt to evolving clinical datasets without retraining on all prior data. However, catastrophic forgetting, where models lose previously acquired knowledge, remains a…

Image and Video Processing · Electrical Eng. & Systems 2025-10-09 Sashank Makanaboyina

Efficient exploration of the vast chemical space is a fundamental challenge in materials design and discovery, particularly for designing functional inorganic crystalline materials with targeted properties. Diffusion-based generative models…

Materials Science · Physics 2026-03-20 Sourav Mal , Nehad Ahmed , Junaid Jami , Subhankar Mishra , Prasenjit Sen

Speech-driven gesture synthesis is a field of growing interest in virtual human creation. However, a critical challenge is the inherent intricate one-to-many mapping between speech and gestures. Previous studies have explored and achieved…

Graphics · Computer Science 2023-02-03 Fan Zhang , Naye Ji , Fuxing Gao , Yongping Li

Diffusion models have achieved remarkable progress in universal image restoration. While existing methods speed up inference by reducing sampling steps, substantial step intervals often introduce cumulative errors. Moreover, they struggle…

Computer Vision and Pattern Recognition · Computer Science 2025-05-09 Hebaixu Wang , Jing Zhang , Haonan Guo , Di Wang , Jiayi Ma , Bo Du

Semantic Image Synthesis (SIS) is among the most popular and effective techniques in the field of face generation and editing, thanks to its good generation quality and the versatility is brings along. Recent works attempted to go beyond…

Computer Vision and Pattern Recognition · Computer Science 2025-04-30 Alex Ergasti , Claudio Ferrari , Tomaso Fontanini , Massimo Bertozzi , Andrea Prati

Discrete diffusion language models improve generation efficiency through parallel token prediction, but standard $X_0$ prediction methods introduce factorization errors by approximating the clean token posterior with independent token-wise…

Computation and Language · Computer Science 2026-05-15 Xun Fang , Yunchen Li , Hang Yuan , Zhou Yu

Diffusion Language Models (DLMs) have recently achieved strong results in text generation. However, their multi-step sampling leads to slow inference, limiting practical use. To address this, we extend Inverse Distillation, a technique…

Machine Learning · Computer Science 2026-02-24 David Li , Nikita Gushchin , Dmitry Abulkhanov , Eric Moulines , Ivan Oseledets , Maxim Panov , Alexander Korotin

Creative sketch is a universal way of visual expression, but translating images from an abstract sketch is very challenging. Traditionally, creating a deep learning model for sketch-to-image synthesis needs to overcome the distorted input…

Computer Vision and Pattern Recognition · Computer Science 2023-05-31 Qiang Wang , Di Kong , Fengyin Lin , Yonggang Qi

Diffusion models have been successfully adapted to text generation tasks by mapping the discrete text into the continuous space. However, there exist nonnegligible gaps between training and inference, owing to the absence of the forward…

Computation and Language · Computer Science 2023-05-09 Zecheng Tang , Pinzheng Wang , Keyan Zhou , Juntao Li , Ziqiang Cao , Min Zhang

We introduce Mediffusion -- a new method for semi-supervised learning with explainable classification based on a joint diffusion model. The medical imaging domain faces unique challenges due to scarce data labelling -- insufficient for…

Computer Vision and Pattern Recognition · Computer Science 2024-11-15 Joanna Kaleta , Paweł Skierś , Jan Dubiński , Przemysław Korzeniowski , Kamil Deja