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The molecular large language models have garnered widespread attention due to their promising potential on molecular applications. However, current molecular large language models face significant limitations in understanding molecules due…

Biomolecules · Quantitative Biology 2025-10-23 Zaifei Yang , Hong Chang , Ruibing Hou , Shiguang Shan , Xilin Chen

Modelling information from complex systems such as humans social interaction or words co-occurrences in our languages can help to understand how these systems are organized and function. Such systems can be modelled by networks, and network…

Computation and Language · Computer Science 2024-12-12 Thibault Prouteau , Nicolas Dugué , Simon Guillot

Language Models (LMs) have demonstrated impressive molecule understanding ability on various 1D text-related tasks. However, they inherently lack 2D graph perception - a critical ability of human professionals in comprehending molecules'…

Computation and Language · Computer Science 2024-01-19 Zhiyuan Liu , Sihang Li , Yanchen Luo , Hao Fei , Yixin Cao , Kenji Kawaguchi , Xiang Wang , Tat-Seng Chua

Implicit solvent models (ISMs) promise to deliver the accuracy of explicit solvent simulations at a fraction of the computational cost. However, despite decades of development, their accuracy has remained insufficient for many critical…

Biological Physics · Physics 2026-03-26 Justin Airas , Bin Zhang

The automatic analysis of chemical literature has immense potential to accelerate the discovery of new materials and drugs. Much of the critical information in patent documents and scientific articles is contained in figures, depicting the…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Lucas Morin , Martin Danelljan , Maria Isabel Agea , Ahmed Nassar , Valery Weber , Ingmar Meijer , Peter Staar , Fisher Yu

A central goal for mechanistic interpretability has been to identify the right units of analysis in large language models (LLMs) that causally explain their outputs. While early work focused on individual neurons, evidence that neurons…

Computation and Language · Computer Science 2026-05-05 Or Shafran , Atticus Geiger , Mor Geva

Foundation models in language and vision have the ability to run inference on any textual and visual inputs thanks to the transferable representations such as a vocabulary of tokens in language. Knowledge graphs (KGs) have different entity…

Computation and Language · Computer Science 2024-04-11 Mikhail Galkin , Xinyu Yuan , Hesham Mostafa , Jian Tang , Zhaocheng Zhu

Statistical generative models for molecular graphs attract attention from many researchers from the fields of bio- and chemo-informatics. Among these models, invertible flow-based approaches are not fully explored yet. In this paper, we…

Machine Learning · Computer Science 2019-10-01 Shion Honda , Hirotaka Akita , Katsuhiko Ishiguro , Toshiki Nakanishi , Kenta Oono

Knowledge Graph Foundation Models (KGFMs) are at the frontier for deep learning on knowledge graphs (KGs), as they can generalize to completely novel knowledge graphs with different relational vocabularies. Despite their empirical success,…

Foundation models (FMs) are changing the way medical images are analyzed by learning from large collections of unlabeled data. Instead of relying on manually annotated examples, FMs are pre-trained to learn general-purpose visual features…

The emergence of large-scale pre-trained language models has revolutionized various AI research domains. Transformers-based Large Language Models (LLMs) have gradually replaced CNNs and RNNs to unify fields of computer vision and natural…

Computation and Language · Computer Science 2024-02-07 Ruosong Ye , Caiqi Zhang , Runhui Wang , Shuyuan Xu , Yongfeng Zhang

Foundation models are used to extract transferable representations from large amounts of unlabeled data, typically via self-supervised learning (SSL). However, many of these models rely on architectures that offer limited interpretability,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Samuel Ofosu Mensah , Camila Roa , Kerol Djoumessi , Philipp Berens

Graph Interpolation Grammars are a declarative formalism with an operational semantics. Their goal is to emulate salient features of the human parser, and notably incrementality. The parsing process defined by GIGs incrementally builds a…

cmp-lg · Computer Science 2009-09-25 John Larcheveque

Molecular machine learning has gained popularity with the advancements of geometric deep learning. In parallel, retrieval-augmented generation has become a principled approach commonly used with language models. However, the optimal…

Machine Learning · Computer Science 2025-07-04 Runzhong Wang , Rui-Xi Wang , Mrunali Manjrekar , Connor W. Coley

Transformer-based language models are effective but complex, and understanding their inner workings and reasoning mechanisms is a significant challenge. Previous research has primarily explored how these models handle simple tasks like name…

Computation and Language · Computer Science 2025-05-20 Zeyuan Allen-Zhu , Yuanzhi Li

With the continuous emergence of various social media platforms frequently used in daily life, the multimodal meme understanding (MMU) task has been garnering increasing attention. MMU aims to explore and comprehend the meanings of memes…

Computation and Language · Computer Science 2025-03-18 Li Zheng , Hao Fei , Ting Dai , Zuquan Peng , Fei Li , Huisheng Ma , Chong Teng , Donghong Ji

The discovery of Metal-Organic Frameworks (MOFs) with application-specific properties remains a central challenge in materials chemistry, owing to the immense size and complexity of their structural design space. Conventional computational…

Machine Learning · Computer Science 2025-06-03 Srivathsan Badrinarayanan , Rishikesh Magar , Akshay Antony , Radheesh Sharma Meda , Amir Barati Farimani

Generative recommendation is an emerging paradigm that leverages the extensive knowledge of large language models by formulating recommendations into a text-to-text generation task. However, existing studies face two key limitations in (i)…

Information Retrieval · Computer Science 2025-06-03 Sunkyung Lee , Minjin Choi , Eunseong Choi , Hye-young Kim , Jongwuk Lee

Coarse-graining (CG) of molecular simulations simplifies the particle representation by grouping selected atoms into pseudo-beads and drastically accelerates simulation. However, such CG procedure induces information losses, which makes…

Machine Learning · Computer Science 2022-06-20 Wujie Wang , Minkai Xu , Chen Cai , Benjamin Kurt Miller , Tess Smidt , Yusu Wang , Jian Tang , Rafael Gómez-Bombarelli

Although they exist since more than ten years already, have attracted diverse implementations, and have been used successfully in a significant number of applications, declarative mapping languages for constructing knowledge graphs from…

Databases · Computer Science 2025-03-25 Sitt Min Oo , Olaf Hartig