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Generative artificial intelligence models learn probability distributions from data and produce novel samples that capture the salient properties of their training sets. Proteins are particularly attractive for such approaches given their…

Biomolecules · Quantitative Biology 2026-02-27 Filippo Stocco , Michele Garibbo , Noelia Ferruz

Click-through rate (CTR) prediction plays important role in personalized advertising and recommender systems. Though many models have been proposed such as FM, FFM and DeepFM in recent years, feature engineering is still a very important…

Information Retrieval · Computer Science 2021-07-27 Qingyun She , Zhiqiang Wang , Junlin Zhang

Proteins are shaped by gradual evolution under biophysical and functional constraints. Protein language models learn rich evolutionary constraints from large-scale sequences, and discrete diffusion-based protein language models~(\eg, DPLMs)…

Machine Learning · Computer Science 2026-05-14 Xinyou Wang , Liang Hong , Jiasheng Ye , Zaixiang Zheng , Yu Li , Shujian Huang , Quanquan Gu

We present EasyGen, an efficient model designed to enhance multimodal understanding and generation by harnessing the capabilities of diffusion models and large language models (LLMs), Unlike existing multimodal models that predominately…

Artificial Intelligence · Computer Science 2024-05-20 Xiangyu Zhao , Bo Liu , Qijiong Liu , Guangyuan Shi , Xiao-Ming Wu

Discrete diffusion models are a powerful, emerging paradigm for code generation. They construct programs through iterative refinement of partially corrupted token sequences and enable parallel token refinement. Importantly, this paradigm…

Computation and Language · Computer Science 2026-05-19 Lize Shao , Michael Cardei , Zichen Xie , Ferdinando Fioretto , Wenxi Wang

Language-aligned vision foundation models perform strongly across diverse downstream tasks. Yet, their learned representations remain opaque, making interpreting their decision-making difficult. Recent work decompose these representations…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Kai Wittenmayer , Sukrut Rao , Amin Parchami-Araghi , Bernt Schiele , Jonas Fischer

Protein language models (pLMs), pre-trained via causal language modeling on protein sequences, have been a promising tool for protein sequence design. In real-world protein engineering, there are many cases where the amino acids in the…

Machine Learning · Computer Science 2023-03-30 Youhan Lee , Hasun Yu

The emergence of Large Language Models (LLMs) has unified language generation tasks and revolutionized human-machine interaction. However, in the realm of image generation, a unified model capable of handling various tasks within a single…

Computer Vision and Pattern Recognition · Computer Science 2024-11-22 Shitao Xiao , Yueze Wang , Junjie Zhou , Huaying Yuan , Xingrun Xing , Ruiran Yan , Chaofan Li , Shuting Wang , Tiejun Huang , Zheng Liu

In recent years, natural language processing (NLP) models have demonstrated remarkable capabilities in various domains beyond traditional text generation. In this work, we introduce PeptideGPT, a protein language model tailored to generate…

Machine Learning · Computer Science 2024-10-28 Aayush Shah , Chakradhar Guntuboina , Amir Barati Farimani

Large Language Models (LLMs) excel at generating fluent text but struggle to enforce external constraints because they generate tokens sequentially without explicit control mechanisms. GenCP addresses this limitation by combining LLM…

Computation and Language · Computer Science 2025-06-02 Alexandre Bonlarron , Florian Régin , Elisabetta De Maria , Jean-Charles Régin

Latent diffusion models (LDMs) dominate high-quality image generation, yet integrating representation learning with generative modeling remains a challenge. We introduce a novel generative image modeling framework that seamlessly bridges…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Theodoros Kouzelis , Efstathios Karypidis , Ioannis Kakogeorgiou , Spyros Gidaris , Nikos Komodakis

Procedural content generation via machine learning (PCGML) is typically framed as the task of fitting a generative model to full-scale examples of a desired content distribution. This approach presents a fundamental tension: the more design…

Machine Learning · Computer Science 2018-09-13 Isaac Karth , Adam M. Smith

The performance of single image super-resolution has achieved significant improvement by utilizing deep convolutional neural networks (CNNs). The features in deep CNN contain different types of information which make different contributions…

Computer Vision and Pattern Recognition · Computer Science 2018-10-01 Yanting Hu , Jie Li , Yuanfei Huang , Xinbo Gao

Attention-based models trained on protein sequences have demonstrated incredible success at classification and generation tasks relevant for artificial intelligence-driven protein design. However, we lack a sufficient understanding of how…

Machine Learning · Computer Science 2022-06-29 Erik Nijkamp , Jeffrey Ruffolo , Eli N. Weinstein , Nikhil Naik , Ali Madani

Recent research on motion generation has shown significant progress in generating semantically aligned motion with singular semantics. However, when employing these models to create composite sequences containing multiple semantically…

Multimedia · Computer Science 2025-10-17 Ho Yin Au , Jie Chen , Junkun Jiang , Jingyu Xiang

Molecular generation and molecular property prediction are both crucial for drug discovery, but they are often developed independently. Inspired by recent studies, which demonstrate that diffusion model, a prominent generative approach, can…

Machine Learning · Computer Science 2025-04-07 Shikun Feng , Yuyan Ni , Yan Lu , Zhi-Ming Ma , Wei-Ying Ma , Yanyan Lan

Generative Adversarial Networks (GANs) have many potential medical imaging applications. Due to the limited memory of Graphical Processing Units (GPUs), most current 3D GAN models are trained on low-resolution medical images, these models…

Computer Vision and Pattern Recognition · Computer Science 2025-03-17 Mahshid Shiri , Alessandro Bruno , Daniele Loiacono

Classifier-free guidance (CFG) is a core technique powering state-of-the-art image generation systems, yet its underlying mechanisms remain poorly understood. In this work, we begin by analyzing CFG in a simplified linear diffusion model,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Xiang Li , Rongrong Wang , Qing Qu

While recent NeRF-based generative models achieve the generation of diverse 3D-aware images, these approaches have limitations when generating images that contain user-specified characteristics. In this paper, we propose a novel model,…

Computer Vision and Pattern Recognition · Computer Science 2021-12-08 Kyungmin Jo , Gyumin Shim , Sanghun Jung , Soyoung Yang , Jaegul Choo

Predicting protein secondary structure is essential for understanding protein function and advancing drug discovery. However, the intricate sequence-structure relationship poses significant challenges for accurate modeling. To address…

Machine Learning · Computer Science 2026-03-16 Yining Qian , Lijie Su , Meiling Xu , Xianpeng Wang