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Magnetic Particle Imaging (MPI) is a tomographic imaging modality capable of real-time, high-sensitivity mapping of superparamagnetic iron oxide nanoparticles. Model-based image reconstruction provides an alternative to conventional methods…

Magnetic particle imaging (MPI) is a medical imaging modality of recent origin, and it exploits the nonlinear magnetization phenomenon to recover the spatially dependent concentration of the nanoparticles. Currently, image reconstruction in…

Numerical Analysis · Mathematics 2019-04-23 Tobias Kluth , Bangti Jin

Magnetic particle imaging (MPI) is a tracer-based imaging modality that detects superparamagnetic iron oxide nanoparticles in vivo, with applications in cancer cell tracking, lymph node mapping, and cell therapy monitoring. We introduce a…

Magnetic Particle Imaging (MPI) is an emerging imaging modality that maps the spatial distribution of magnetic nanoparticles. The x-space reconstruction in MPI results in highly blurry images, where the resolution depends on both system…

Medical Physics · Physics 2020-01-31 Onur Yorulmaz , Omer Burak Demirel , Yavuz Muslu , Tolga Çukur , Emine U Saritas , A Enis Çetin

Objective: Magnetic particle imaging (MPI) is an emerging medical imaging modality which has gained increasing interest in recent years. Among the benefits of MPI are its high temporal resolution, and that the technique does not expose the…

Image and Video Processing · Electrical Eng. & Systems 2025-04-29 Vladyslav Gapyak , Corinna Rentschler , Thomas März , Andreas Weinmann

Magnetic particle imaging (MPI) is an imaging method that can visualize magnetic nanoparticles in positive contrast, without radiation exposure. Recently, we proposed an image reconstruction method for projection-based MPI (pMPI), in which…

Medical Physics · Physics 2023-05-01 Kenya Murase

Magnetic Particle Imaging (MPI) is a promising noninvasive in vivo imaging modality that makes it possible to map the spatial distribution of superparamagnetic nanoparticles by exposing them to dynamic magnetic fields. In the Field-Free…

Numerical Analysis · Mathematics 2025-08-08 Vladyslav Gapyak , Thomas März , Andreas Weinmann

Magnetic particle imaging (MPI) offers unparalleled contrast and resolution for tracing magnetic nanoparticles. A common imaging procedure calibrates a system matrix (SM) that is used to reconstruct data from subsequent scans. The ill-posed…

Image and Video Processing · Electrical Eng. & Systems 2023-09-07 Alper Güngör , Baris Askin , Damla Alptekin Soydan , Can Barış Top , Emine Ulku Saritas , Tolga Çukur

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic tool that provides excellent soft-tissue contrast without the use of ionizing radiation. Compared to other clinical imaging modalities (e.g., CT or ultrasound), however, the data…

Computer Vision and Pattern Recognition · Computer Science 2020-02-19 Rizwan Ahmad , Charles A. Bouman , Gregery T. Buzzard , Stanley Chan , Sizhou Liu , Edward T. Reehorst , Philip Schniter

We contribute to the mathematical modeling and analysis of magnetic particle imaging which is a promising new in-vivo imaging modality. Concerning modeling, we develop a structured decomposition of the imaging process and extract its core…

Numerical Analysis · Mathematics 2016-05-27 Thomas März , Andreas Weinmann

We derive a new 3D model for magnetic particle imaging (MPI) that is able to incorporate realistic magnetic fields in the reconstruction process. In real MPI scanners, the generated magnetic fields have distortions that lead to deformed…

Numerical Analysis · Mathematics 2020-12-30 Gaël Bringout , Wolfgang Erb , Jürgen Frikel

Magnetic particle imaging (MPI) is an emerging medical imaging modality which offers a unique combination of high temporal and spatial resolution, sensitivity and biocompatibility. For system-matrix (SM) based image reconstruction in MPI, a…

Software Engineering · Computer Science 2024-01-12 Anselm von Gladiss , Amir Shayan Ahmadian , Jan Jürjens

Purpose: To develop a general framework for Parallel Imaging (PI) with the use of Maxwell regularization for the estimation of the sensitivity maps (SMs) and constrained optimization for the parameter-free image reconstruction. Theory and…

Image and Video Processing · Electrical Eng. & Systems 2020-08-21 Matteo Alessandro Francavilla , Stamatios Lefkimmiatis , Jorge F. Villena , Athanasios G. Polimeridis

Magnetic particle imaging (MPI) is an imaging modality exploiting the nonlinear magnetization behavior of (super-)paramagnetic nanoparticles to obtain a space- and often also time-dependent concentration of a tracer consisting of these…

Image and Video Processing · Electrical Eng. & Systems 2020-07-06 Sören Dittmer , Tobias Kluth , Mads Thorstein Roar Henriksen , Peter Maass

Magnetic Particle Imaging (MPI) is a recent imaging modality where superparamagnetic nanoparticles are employed as tracers. The reconstruction task is to obtain the spatial particle distribution from a voltage signal induced by the…

Numerical Analysis · Mathematics 2025-08-11 Thomas März , Vladyslav Gapyak , Andreas Weinmann

The image reconstruction problem of the tomographic imaging technique magnetic particle imaging (MPI) requires the solution of a linear inverse problem. One prerequisite for this task is that the imaging operator that describes the mapping…

Computational Physics · Physics 2019-07-12 Tobias Kluth , Patryk Szwargulski , Tobias Knopp

Model-based reconstruction approaches for the medical imaging modality Magnetic Particle Imaging (MPI) are typically based on the Langevin model, which assumes instantaneous alignment of the particles magnetic momenta with the applied…

Numerical Analysis · Mathematics 2026-03-13 Vladyslav Gapyak , Thomas März , Andreas Weinmann

Objective: This work introduces a new magnetic particle imaging (MPI) reconstruction framework based on multi-harmonic 3D deconvolution (MH3D) of gridded portraits, offering a principled, model-driven approach to MPI imaging. Approach: MH3D…

Numerical Analysis · Mathematics 2025-10-02 Toby Sanders , Justin J. Konkle , Erica E. Mason , Patrick W. Goodwill

Magnetic Particle Imaging (MPI) is a preclinical imaging technique capable of visualizing the spatio-temporal distribution of magnetic nanoparticles. The image reconstruction of this fast and dynamic process relies on efficiently solving an…

Numerical Analysis · Mathematics 2021-09-15 Florian Lieb , Tobias Knopp

The purpose of this study was to present image reconstruction methods for magnetic particle imaging (MPI) with a field-free-line (FFL) encoding scheme and to propose the use of the maximum likelihood-expectation maximization (ML-EM)…

Medical Physics · Physics 2016-06-13 Kenya Murase
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