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Recent studies of genotype-phenotype (GP) maps have reported universally enhanced phenotypic robustness to genotype mutations, a feature essential to evolution. Virtually all of these studies make a simplifying assumption that each genotype…

Statistical Mechanics · Physics 2025-01-07 Anna Sappington , Vaibhav Mohanty

We present a novel multivariate classification technique based on Genetic Programming. The technique is distinct from Genetic Algorithms and offers several advantages compared to Neural Networks and Support Vector Machines. The technique…

Data Analysis, Statistics and Probability · Physics 2009-11-10 Kyle Cranmer , R. Sean Bowman

Identifying genes associated with complex human diseases is one of the main challenges of human genetics and computational medicine. To answer this question, millions of genetic variants get screened to identify a few of importance. To…

Genomics · Quantitative Biology 2015-09-01 Aziz M. Mezlini , Fabio Fuligni , Adam Shlien , Anna Goldenberg

Diabetes is a worldwide health issue affecting millions of people. Machine learning methods have shown promising results in improving diabetes prediction, particularly through the analysis of diverse data types, namely gene expression data.…

Machine Learning · Computer Science 2024-04-24 Rita T. Sousa , Heiko Paulheim

Background: Advances in high throughput sequencing technologies provide a huge number of genomes to be analyzed. Thus, computational methods play a crucial role in analyzing and extracting knowledge from the data generated. Investigating…

Semantic GP is a promising approach that introduces semantic awareness during genetic evolution. This paper presents a new Semantic GP approach based on Dynamic Target (SGP-DT) that divides the search problem into multiple GP runs. The…

Neural and Evolutionary Computing · Computer Science 2020-02-03 Stefano Ruberto , Valerio Terragni , Jason H. Moore

Software Testing is a process to identify the quality and reliability of software, which can be achieved through the help of proper test data. However, doing this manually is a difficult task due to the presence of number of predicate nodes…

Software Engineering · Computer Science 2014-01-22 Yeresime Suresh , Santanu Ku. Rath

While much research effort has been dedicated to scaling up sparse Gaussian process (GP) models based on inducing variables for big data, little attention is afforded to the other less explored class of low-rank GP approximations that…

Machine Learning · Statistics 2016-11-21 Quang Minh Hoang , Trong Nghia Hoang , Kian Hsiang Low

The Uncertain Agile Earth Observation Satellite Scheduling Problem (UAEOSSP) is a novel combinatorial optimization problem and a practical engineering challenge that aligns with the current demands of space technology development. It…

Artificial Intelligence · Computer Science 2026-03-19 Junhua Xue , Yuning Chen , Mingyan Shao , Yangming Zhou , Qinghua Wu , Yingwu Chen

Identifying genes that display spatial patterns is critical to investigating expression interactions within a spatial context and further dissecting biological understanding of complex mechanistic functionality. Despite the increase in…

Methodology · Statistics 2025-10-06 Mingcong Wu , Yang Li , Shuangge Ma , Mengyun Wu

Decreasing costs and new technologies have led to an increase in the amount of data available to plant breeding programs. High-throughput phenotyping (HTP) platforms routinely generate high-dimensional datasets of secondary features that…

Program synthesis aims to {\it automatically} find programs from an underlying programming language that satisfy a given specification. While this has the potential to revolutionize computing, how to search over the vast space of programs…

Neural and Evolutionary Computing · Computer Science 2022-03-01 Yuan Yuan , Wolfgang Banzhaf

Owing to the remarkable photometric precision of space observatories like Kepler, stellar and planetary systems beyond our own are now being characterized en masse for the first time. These characterizations are pivotal for endeavors such…

Solar and Stellar Astrophysics · Physics 2017-04-03 Earl P. Bellinger , George C. Angelou , Saskia Hekker , Sarbani Basu , Warrick Ball , Elisabeth Guggenberger

Prompt-based techniques have demostrated great potential for improving the few-shot generalization of pretrained language models. However, their performance heavily relies on the manual design of prompts and thus requires a lot of human…

Computation and Language · Computer Science 2022-11-01 Hanwei Xu , Yujun Chen , Yulun Du , Nan Shao , Yanggang Wang , Haiyu Li , Zhilin Yang

Genetic programming (GP) is a commonly used approach to solve symbolic regression (SR) problems. Compared with the machine learning or deep learning methods that depend on the pre-defined model and the training dataset for solving SR…

Neural and Evolutionary Computing · Computer Science 2022-05-23 Baihe He , Qiang Lu , Qingyun Yang , Jake Luo , Zhiguang Wang

Developments in Genome-Wide Association Studies have led to the increasing notion that future healthcare techniques will be personalized to the patient, by relying on genetic tests to determine the risk of developing a disease. To this end,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-01-27 Diogo Marques , Rafael Campos , Sergio Santander-Jiménez , Zakhar Matveev , Leonel Sousa , Aleksandar Ilic

Convolutional neural networks (CNNs) are effective at solving difficult problems like visual recognition, speech recognition and natural language processing. However, performance gain comes at the cost of laborious trial-and-error in…

Neural and Evolutionary Computing · Computer Science 2018-12-20 Yiheng Zhu , Yichen Yao , Zili Wu , Yujie Chen , Guozheng Li , Haoyuan Hu , Yinghui Xu

Gene expression analysis aims at identifying the genes able to accurately predict biological parameters like, for example, disease subtyping or progression. While accurate prediction can be achieved by means of many different techniques,…

Methodology · Statistics 2008-09-11 Christine De Mol , Sofia Mosci , Magali Traskine , Alessandro Verri

This paper proposes Genetic Algorithm with Border Trades (GAB), a novel modification of the standard genetic algorithm that enhances exploration by incorporating new chromosome patterns in the breeding process. This approach significantly…

Machine Learning · Computer Science 2025-06-27 Qingchuan Lyu

In cancer research, profiling studies have been extensively conducted, searching for genes/SNPs associated with prognosis. Cancer is a heterogeneous disease. Examining similarity and difference in the genetic basis of multiple subtypes of…

Methodology · Statistics 2013-04-18 Jin Liu , Jian Huang , Yawei Zhang , Qing Lan , Nathaniel Rothman , Tongzhang Zheng , Shuangge Ma