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A key overall goal of biomolecular simulations is the characterization of "mechanism" -- the pathways through configuration space of processes such as conformational transitions and binding. Some amount of heterogeneity is intrinsic to the…

Chemical Physics · Physics 2018-10-25 Ernesto Suárez , Daniel M. Zuckerman

To our knowledge, the existing measure approximation theory requires the diffusion term of the stochastic delay differential equations (SDDEs) to be globally Lipschitz continuous. Our work is to develop a new explicit numerical method for…

Probability · Mathematics 2023-03-13 Li Xiaoyue , Mao Xuerong , Song guoting

Spatial reaction-diffusion models have been employed to describe many emergent phenomena in biological systems. The modelling technique most commonly adopted in the literature implements systems of partial differential equations (PDEs),…

Quantitative Methods · Quantitative Biology 2015-10-05 Christian A. Yates , Mark B. Flegg

In recent years, advancements in deep learning have spurred the development of numerous models for Long-term Time Series Forecasting (LTSF). However, most existing approaches struggle to fully capture the complex and structured dependencies…

Machine Learning · Computer Science 2025-06-04 Zixuan Weng , Jindong Han , Wenzhao Jiang , Hao Liu

The aim of this paper is to obtain convergence in mean in the uniform topology of piecewise linear approximations of Stochastic Differential Equations (SDEs) with $C^1$ drift and $C^2$ diffusion coefficients with uniformly bounded…

Probability · Mathematics 2025-03-13 Sahani Pathiraja

We present a message-passing algorithm to solve the edge disjoint path problem (EDP) on graphs incorporating under a unique framework both traffic optimization and path length minimization. The min-sum equations for this problem present an…

Disordered Systems and Neural Networks · Physics 2016-01-21 Fabrizio Altarelli , Alfredo Braunstein , Luca Dall'Asta , Caterina De Bacco , Silvio Franz

In this paper, we assess the state of the art in pedestrian trajectory prediction within the context of generating single trajectories, a critical aspect aligning with the requirements in autonomous systems. The evaluation is conducted on…

Machine Learning · Computer Science 2024-04-08 Nico Uhlemann , Felix Fent , Markus Lienkamp

Diffusion coefficients are key thermophysical properties for modeling mass transport in liquids, but experimental data are scarce, making reliable prediction methods indispensable. In the present work, we introduce a new method for…

Imperfect score-matching leads to a shift between the training and the sampling distribution of diffusion models. Due to the recursive nature of the generation process, errors in previous steps yield sampling iterates that drift away from…

Machine Learning · Computer Science 2023-02-20 Giannis Daras , Yuval Dagan , Alexandros G. Dimakis , Constantinos Daskalakis

A potent class of generative models known as Diffusion Probabilistic Models (DPMs) has become prominent. A forward diffusion process adds gradually noise to data, while a model learns to gradually denoise. Sampling from pre-trained DPMs is…

Machine Learning · Computer Science 2023-10-27 Martin Gonzalez , Nelson Fernandez , Thuy Tran , Elies Gherbi , Hatem Hajri , Nader Masmoudi

In this paper, we investigate the problem of strong approximation of the solutions of stochastic differential equations (SDEs) when the drift coefficient is given in integral form. We investigate its upper error bounds, in terms of the…

Numerical Analysis · Mathematics 2025-11-20 Paweł Przybyłowicz , Michał Sobieraj

Via constructing an asymptotic coupling by reflection, in this paper we establish uniform-in-time estimates on probability distances for mean-field type SDEs, where the drift terms under consideration are dissipative merely in the long…

Probability · Mathematics 2024-09-26 Jianhai Bao , Jiaqing Hao

By means of an original approach, called "method of the moving frame", we establish existence, uniqueness and stability results for mild and weak solutions of stochastic partial differential equations (SPDEs) with path dependent…

Probability · Mathematics 2010-01-18 Damir Filipovic , Stefan Tappe , Josef Teichmann

The ensemble average of physical properties of molecules is closely related to the distribution of molecular conformations, and sampling such distributions is a fundamental challenge in physics and chemistry. Traditional methods like…

Machine Learning · Computer Science 2025-08-06 Liya Guo , Zun Wang , Chang Liu , Junzhe Li , Pipi Hu , Yi Zhu

We develop the theory linking 'E-separation' in directed mixed graphs (DMGs) with conditional independence relations among coordinate processes in stochastic differential equations (SDEs), where causal relationships are determined by "which…

Machine Learning · Computer Science 2025-03-14 Georg Manten , Cecilia Casolo , Søren Wengel Mogensen , Niki Kilbertus

In many applications, it is often necessary to sample the mean value of certain quantity with respect to a probability measure {\mu} on the level set of a smooth function $\xi: \mathbb{R}^d\rightarrow \mathbb{R}^k$, $1\le k < d$. A…

Probability · Mathematics 2019-09-25 Wei Zhang

We study strong approximation of $d$-dimensional stochastic differential equations (SDEs) with a discontinuous drift coefficient. More precisely, we essentially assume that the drift coefficient is piecewise Lipschitz continuous with an…

Numerical Analysis · Mathematics 2025-04-03 Thomas Müller-Gronbach , Christopher Rauhögger , Larisa Yaroslavtseva

The embedded topic model (ETM) is a widely used approach that assumes the sampled document-topic distribution conforms to the logistic normal distribution for easier optimization. However, this assumption oversimplifies the real…

Computation and Language · Computer Science 2025-01-03 Wei Shao , Mingyang Liu , Linqi Song

Nonlinear and delayed effects of covariates often render time series forecasting challenging. To this end, we propose a novel forecasting framework based on ridge regression with signature features calculated on sliding windows. These…

Methodology · Statistics 2025-10-15 Nina Drobac , Margaux Brégère , Joseph de Vilmarest , Olivier Wintenberger

We consider a process given as the solution of a stochastic differential equation with irregular, path dependent and time-inhomogeneous drift coefficient and additive noise. Explicit and optimal bounds for the Lebesgue density of that…

Probability · Mathematics 2015-08-04 David Baños , Paul Krühner