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Clinical and genomic models are both used to predict breast cancer outcomes, but they are often combined using simple linear rules that do not account for how their risk scores relate, especially at the extremes. Using the METABRIC breast…

Machine Learning · Computer Science 2025-11-25 Agnideep Aich , Sameera Hewage , Md Monzur Murshed

We present the Deep Copula Classifier (DCC), a class-conditional generative model that separates marginal estimation from dependence modeling using neural copula densities. DCC is interpretable, Bayes-consistent, and achieves excess-risk…

Machine Learning · Statistics 2025-10-28 Agnideep Aich , Ashit Baran Aich

Background and objective: Diabetes is a chronic pathology which is affecting more and more people over the years. It gives rise to a large number of deaths each year. Furthermore, many people living with the disease do not realize the…

As the meta-analysis of more than one diagnostic tests can impact clinical decision making and patient health, there is an increasing body of research in models and methods for meta-analysis of studies comparing multiple diagnostic tests.…

Methodology · Statistics 2021-05-11 Aristidis K. Nikoloulopoulos

A huge amount of medical data is generated every day, which presents a challenge in analysing these data. The obvious solution to this challenge is to reduce the amount of data without information loss. Dimension reduction is considered the…

Computers and Society · Computer Science 2015-11-24 Noura AlNuaimi , Mohammad M Masud , Farhan Mohammed

Globally, chronic liver disease continues to be a major health concern that requires precise predictive models for prompt detection and treatment. Using the Indian Liver Patient Dataset (ILPD) from the University of California at Irvine's…

Machine Learning · Computer Science 2024-12-31 Anand Karna , Naina Khan , Rahul Rauniyar , Prashant Giridhar Shambharkar

This study aimed to develop a machine learning (ML) algorithm capable of determining cardiovascular risk in multimodal retinal images from patients with type 1 diabetes mellitus, distinguishing between moderate, high, and very high-risk…

In many nations, diabetes is becoming a significant health problem, and early identification and control are crucial. Using machine learning algorithms to predict diabetes has yielded encouraging results. Using the Pima Indians Diabetes…

Machine Learning · Computer Science 2025-06-13 Mowafaq Salem Alzboon , Mohammad Al-Batah , Muhyeeddin Alqaraleh , Ahmad Abuashour , Ahmad Fuad Bader

Identifying predictive features from high-dimensional datasets is a major task in biomedical research. However, it is difficult to determine the robustness of selected features. Here, we investigate the performance of randomly chosen…

Quantitative Methods · Quantitative Biology 2024-11-28 Randall J. Ellis , Audrey Airaud , Chirag J. Patel

Learning the joint dependence of discrete variables is a fundamental problem in machine learning, with many applications including prediction, clustering and dimensionality reduction. More recently, the framework of copula modeling has…

Machine Learning · Statistics 2013-11-15 Alfredo Kalaitzis , Ricardo Silva

Class imbalance remains a practical obstacle in the development of clinical prediction models for conditions such as diabetes mellitus, where the number of confirmed cases is often much smaller than the number of controls. The Synthetic…

Machine Learning · Computer Science 2026-05-26 Agnideep Aich , Md Monzur Murshed , Bruce Wade , Sameera Hewage

The paper presents a new copula based method for measuring dependence between random variables. Our approach extends the Maximum Mean Discrepancy to the copula of the joint distribution. We prove that this approach has several advantageous…

Machine Learning · Computer Science 2019-08-15 Barnabas Poczos , Zoubin Ghahramani , Jeff Schneider

Diabetes has emerged as a significant global health issue, especially with the increasing number of cases in many countries. This trend Underlines the need for a greater emphasis on early detection and proactive management to avert or…

Machine Learning · Computer Science 2025-06-16 Mowafaq Salem Alzboon , Muhyeeddin Alqaraleh , Mohammad Subhi Al-Batah

The use of artificial intelligence in clinical care to improve decision support systems is increasing. This is not surprising since, by its very nature, the practice of medicine consists of making decisions based on observations from…

Quantitative Methods · Quantitative Biology 2019-05-03 Isaac Mativo , Yelena Yesha , Michael Grasso , Tim Oates , Qian Zhu

In this study, we investigated the application of bio-inspired optimization algorithms, including Genetic Algorithm, Particle Swarm Optimization, and Whale Optimization Algorithm, for feature selection in chronic disease prediction. The…

Neural and Evolutionary Computing · Computer Science 2024-01-12 Abeer Dyoub , Ivan Letteri

The anomaly detection method presented by this paper has a special feature: it does not only indicate whether an observation is anomalous or not but also tells what exactly makes an anomalous observation unusual. Hence, it provides support…

Machine Learning · Computer Science 2019-12-05 Gábor Horváth , Edith Kovács , Roland Molontay , Szabolcs Nováczki

Background/Purpose: Diabetes affects over 537 million people worldwide and is projected to reach 783 million by 2045. Early risk stratification can benefit from machine learning. We compare two hybrid classifiers and assess their…

Machine Learning · Computer Science 2025-09-26 Athar Parvez , Muhammad Jawad Mufti

Screening for ultrahigh dimensional features may encounter complicated issues such as outlying observations, heteroscedasticity or heavy-tailed distribution, multi-collinearity and confounding effects. Standard correlation-based marginal…

Statistics Theory · Mathematics 2018-12-27 Xiaochao Xia , Jialiang Li

Diabetes mellitus affects over 537 million adults worldwide and remains a major challenge in preventive healthcare. Existing machine-learning studies primarily formulate diabetes prediction as a binary classification problem, while…

Machine Learning · Computer Science 2026-05-14 Vishal Pandey , Ruzina Haque Laskar , Rishav Tewari

Copulas have gained widespread popularity as statistical models to represent dependence structures between multiple variables in various applications. The minimum information copula, given a finite number of constraints in advance, emerges…

Methodology · Statistics 2024-03-14 Issey Sukeda , Tomonari Sei
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