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Patient-specific bone models are essential for designing surgical guides and preoperative planning, as they enable the visualization of intricate anatomical structures. However, traditional CT-based approaches for creating bone models are…

Low bone mineral density (BMD) is believed to influence the outcome of instrumented spinal surgery and can lead to reoperation. Purpose of this observational and case-control study was to investigate the association of BMD with the risk of…

We propose a fast beam orientation selection method, based on deep neural networks (DNN), capable of developing a plan comparable to those by the state-of-the-art column generation method. The novelty of Our model lies in its supervised…

Medical Physics · Physics 2019-12-23 Azar Sadeghnejad Barkousaraie , Olalekan Ogunmolu , Steve Jiang , Dan Nguyen

Several neurodegenerative diseases involve the accumulation of cellular DNA damage. Comet assays are a popular way of estimating the extent of DNA damage. Current literature on the use of deep learning to quantify DNA damage presents an…

Quantitative Methods · Quantitative Biology 2021-12-28 Srikanth Namuduri , Prateek Mehta , Lise Barbe , Stephanie Lam , Zohreh Faghihmonzavi , Steve Finkbeiner , Shekhar Bhansali

The inaccuracy of neural network models on inputs that do not stem from the training data distribution is both problematic and at times unrecognized. Model uncertainty estimation can address this issue, where uncertainty estimates are often…

Machine Learning · Computer Science 2020-02-14 Siddhartha Jain , Ge Liu , Jonas Mueller , David Gifford

The use of Deep Neural Network (DNN) models in risk-based decision-making has attracted extensive attention with broad applications in medical, finance, manufacturing, and quality control. To mitigate prediction-related risks in decision…

Machine Learning · Statistics 2023-10-11 Maryam Kheirandish , Shengfan Zhang , Donald G. Catanzaro , Valeriu Crudu

Total-body dual X-ray absorptiometry (TBDXA) imaging is a relatively low-cost whole-body imaging modality, widely used for body composition assessment. We develop and validate a deep learning method for automatic fiducial point placement on…

Computer Vision and Pattern Recognition · Computer Science 2025-08-15 Arianna Bunnell , Devon Cataldi , Yannik Glaser , Thomas K. Wolfgruber , Steven Heymsfield , Alan B. Zonderman , Thomas L. Kelly , Peter Sadowski , John A. Shepherd

Musculoskeletal disorders represent a leading cause of global disability, creating an urgent demand for precise interpretation of medical imaging. Current artificial intelligence (AI) approaches in orthopedics predominantly rely on…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Kang Yu , Dingyu Wang , Zimu Yuan , Nan Zhou , Jiajun Liu , Jiaxin Liu , Shanggui Liu , Yaoyan Zheng , Huishu Yuan , Di Huang , Dong Jiang

Accurate bone tracking is crucial for kinematic analysis in orthopedic surgery and prosthetic robotics. Traditional methods (e.g., skin markers) are subject to soft tissue artifacts, and the bone pins used in surgery introduce the risk of…

Signal Processing · Electrical Eng. & Systems 2024-06-03 Bangyu Lan , Stefano Stramigioli , Kenan Niu

Deep learning has revolutionized the early detection of breast cancer, resulting in a significant decrease in mortality rates. However, difficulties in obtaining annotations and huge variations in distribution between training sets and real…

Computer Vision and Pattern Recognition · Computer Science 2024-09-02 Yuxiang Yang , Xinyi Zeng , Pinxian Zeng , Binyu Yan , Xi Wu , Jiliu Zhou , Yan Wang

Along with rich health-related metadata, medical images have been acquired for over 40,000 male and female UK Biobank participants, aged 44-82, since 2014. Phenotypes derived from these images, such as measurements of body composition from…

Image and Video Processing · Electrical Eng. & Systems 2021-09-16 Taro Langner , Fredrik K. Gustafsson , Benny Avelin , Robin Strand , Håkan Ahlström , Joel Kullberg

In radiotherapy, the internal movement of organs between treatment sessions causes errors in the final radiation dose delivery. Motion models can be used to simulate motion patterns and assess anatomical robustness before delivery.…

Osteoporosis is a skeletal disorder that leads to increased fracture risk due to decreased strength of cortical and trabecular bone. Even with state-of-the-art non-invasive assessment methods there is still a high underdiagnosis rate.…

Image and Video Processing · Electrical Eng. & Systems 2020-10-06 Stefan Reinhold , Timo Damm , Sebastian Büsse , Stanislav N. Gorb , Claus-C. Glüer , Reinhard Koch

In critical decision support systems based on medical imaging, the reliability of AI-assisted decision-making is as relevant as predictive accuracy. Although deep learning models have demonstrated significant accuracy, they frequently…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Hua Xu , Julián D. Arias-Londoño , Juan I. Godino-Llorente

Deep neural networks (NNs) are powerful black box predictors that have recently achieved impressive performance on a wide spectrum of tasks. Quantifying predictive uncertainty in NNs is a challenging and yet unsolved problem. Bayesian NNs,…

Machine Learning · Statistics 2017-11-07 Balaji Lakshminarayanan , Alexander Pritzel , Charles Blundell

Prediction uncertainty estimation has clinical significance as it can potentially quantify prediction reliability. Clinicians may trust 'blackbox' models more if robust reliability information is available, which may lead to more models…

Machine Learning · Computer Science 2022-10-04 Michael Dohopolski , Kai Wang , Biling Wang , Ti Bai , Dan Nguyen , David Sher , Steve Jiang , Jing Wang

Knee osteoarthritis (OA) is a widespread chronic condition that impairs mobility and diminishes quality of life. Despite the proven benefits of exercise therapy and patient education in managing the OA symptoms pain and functional…

Machine Learning · Computer Science 2024-10-17 M. Rafiei , S. Das , M. Bakhtiari , E. M. Roos , S. T. Skou , D. T. Grønne , J. Baumbach , L. Baumbach

Deep learning models (DLMs) can achieve state-of-the-art performance in histopathology image segmentation and classification, but have limited deployment potential in real-world clinical settings. Uncertainty estimates of DLMs can increase…

Image and Video Processing · Electrical Eng. & Systems 2024-12-31 Audrey Xie , Elhoucine Elfatimi , Sambuddha Ghosal , Pratik Shah

Bayesian neural networks and deep ensemble methods have been proposed for uncertainty quantification; however, they are computationally intensive and require large storage. By utilizing a single deterministic model, we can solve the above…

Machine Learning · Computer Science 2025-08-04 Yaxin Ma , Benjamin Colburn , Jose C. Principe

Image reconstruction methods based on deep neural networks have shown outstanding performance, equalling or exceeding the state-of-the-art results of conventional approaches, but often do not provide uncertainty information about the…

Computer Vision and Pattern Recognition · Computer Science 2020-12-01 Riccardo Barbano , Željko Kereta , Chen Zhang , Andreas Hauptmann , Simon Arridge , Bangti Jin