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Guiding unconditional diffusion models typically requires either retraining with conditional inputs or per-step gradient computations (e.g., classifier-based guidance), both of which incur substantial computational overhead. We present a…

Machine Learning · Computer Science 2026-02-13 Qingsong Wang , Mikhail Belkin , Yusu Wang

Diffusion Language Models (DLMs) have recently achieved significant success due to their any-order generation capabilities. However, existing inference methods typically rely on local, immediate-step metrics such as confidence or entropy…

Computation and Language · Computer Science 2025-12-03 Kecheng Chen , Ziru Liu , Xijia Tao , Hui Liu , Xinyu Fu , Suiyun Zhang , Dandan Tu , Lingpeng Kong , Rui Liu , Haoliang Li

Reinforcement learning (RL) has achieved remarkable success in a wide range of sequential decision-making problems. Recent diffusion-based policies further improve RL by modeling complex, high-dimensional action distributions. However,…

Machine Learning · Computer Science 2026-02-11 Xiaofeng Xiao , Xiao Hu , Yang Ye , Xubo Yue

Generative models have the potential to accelerate key steps in the discovery of novel molecular therapeutics and materials. Diffusion models have recently emerged as a powerful approach, excelling at unconditional sample generation and,…

Biomolecules · Quantitative Biology 2024-07-17 Leo Klarner , Tim G. J. Rudner , Garrett M. Morris , Charlotte M. Deane , Yee Whye Teh

Classifier free guidance has shown strong potential in diffusion-based reinforcement learning. However, existing methods rely on joint training of the guidance module and the diffusion model, which can be suboptimal during the early stages…

Machine Learning · Computer Science 2025-06-05 Zhaoyang Chen , Cody Fleming

Diffusion models emerged as a leading approach in text-to-image generation, producing high-quality images from textual descriptions. However, attempting to achieve detailed control to get a desired image solely through text remains a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-12 Pablo Domingo-Gregorio , Javier Ruiz-Hidalgo

Diffusion models have demonstrated impressive abilities in generating photo-realistic and creative images. To offer more controllability for the generation process, existing studies, termed as early-constraint methods in this paper,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Chang Liu , Rui Li , Kaidong Zhang , Xin Luo , Dong Liu

Controlled generation with pre-trained Diffusion and Flow Matching models has vast applications. One strategy for guiding ODE-based generative models is through optimizing a target loss $R(x_1)$ while staying close to the prior…

Machine Learning · Computer Science 2025-03-11 Luran Wang , Chaoran Cheng , Yizhen Liao , Yanru Qu , Ge Liu

This tutorial provides an in-depth guide on inference-time guidance and alignment methods for optimizing downstream reward functions in diffusion models. While diffusion models are renowned for their generative modeling capabilities,…

Artificial Intelligence · Computer Science 2025-01-22 Masatoshi Uehara , Yulai Zhao , Chenyu Wang , Xiner Li , Aviv Regev , Sergey Levine , Tommaso Biancalani

Robotic control policies learned from human demonstrations have achieved impressive results in many real-world applications. However, in scenarios where initial performance is not satisfactory, as is often the case in novel open-world…

This paper focuses on the critical load restoration problem in distribution systems following major outages. To provide fast online response and optimal sequential decision-making support, a reinforcement learning (RL) based approach is…

Systems and Control · Electrical Eng. & Systems 2024-01-30 Xiangyu Zhang , Abinet Tesfaye Eseye , Bernard Knueven , Weijia Liu , Matthew Reynolds , Wesley Jones

Controllable generation is a fundamental task in NLP with many applications, providing a basis for function calling to agentic communication. However, even state-of-the-art autoregressive Large Language Models (LLMs) today exhibit…

Computation and Language · Computer Science 2025-09-29 Zhen Xiong , Yujun Cai , Zhecheng Li , Yiwei Wang

Knowledge distillation is a key technique for transferring the capabilities of large language models (LLMs) into smaller, more efficient student models. Existing distillation approaches often overlook two critical factors: the learning…

Machine Learning · Computer Science 2026-05-13 Jincheng Cao , Fanzhi Zeng , Leqi Liu , Aryan Mokhtari

Achieving global optimality in nonlinear model predictive control (NMPC) is challenging due to the non-convex nature of the underlying optimization problem. Since commonly employed local optimization techniques depend on carefully chosen…

Systems and Control · Electrical Eng. & Systems 2025-06-19 Tzu-Yuan Huang , Armin Lederer , Nicolas Hoischen , Jan Brüdigam , Xuehua Xiao , Stefan Sosnowski , Sandra Hirche

Non-contrast CT (NCCT) imaging may reduce image contrast and anatomical visibility, potentially increasing diagnostic uncertainty. In contrast, contrast-enhanced CT (CECT) facilitates the observation of regions of interest (ROI). Leading…

Image and Video Processing · Electrical Eng. & Systems 2024-11-18 Tingyi Lin , Pengju Lyu , Jie Zhang , Yuqing Wang , Cheng Wang , Jianjun Zhu

Generative models have become a powerful tool for synthesizing training data in computer vision tasks. Current approaches solely focus on aligning generated images with the target dataset distribution. As a result, they capture only the…

Computer Vision and Pattern Recognition · Computer Science 2026-01-08 Zerun Wang , Jiafeng Mao , Xueting Wang , Toshihiko Yamasaki

Therapeutic antibodies require not only high-affinity target engagement, but also favorable manufacturability, stability, and safety profiles for clinical effectiveness. These properties are collectively called `developability'. To enable a…

Machine Learning · Computer Science 2025-07-04 Siqi Zhao , Joshua Moller , Porfi Quintero-Cadena , Lood van Niekerk

In this paper, we investigate a practical yet challenging task: On-the-fly Category Discovery (OCD). This task focuses on the online identification of newly arriving stream data that may belong to both known and unknown categories,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Xiao Liu , Nan Pu , Haiyang Zheng , Wenjing Li , Nicu Sebe , Zhun Zhong

Image restoration is a long-standing problem in low-level computer vision with many interesting applications. We describe a flexible learning framework based on the concept of nonlinear reaction diffusion models for various image…

Computer Vision and Pattern Recognition · Computer Science 2016-08-23 Yunjin Chen , Thomas Pock

Score-based generative modeling, informally referred to as diffusion models, continue to grow in popularity across several important domains and tasks. While they provide high-quality and diverse samples from empirical distributions,…

Machine Learning · Statistics 2023-12-29 Jacopo Teneggi , Matthew Tivnan , J. Webster Stayman , Jeremias Sulam