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Large Language Model (LLM)-empowered multi-agent systems extend the cognitive boundaries of individual agents through disciplined collaboration and interaction, while constructing these systems often requires labor-intensive manual designs.…

Machine Learning · Computer Science 2025-06-10 Guibin Zhang , Luyang Niu , Junfeng Fang , Kun Wang , Lei Bai , Xiang Wang

Large Language Models (LLMs) have revolutionized recommendation agents by providing superior reasoning and flexible decision-making capabilities. However, existing methods mainly follow a passive information acquisition paradigm, where…

Information Retrieval · Computer Science 2026-03-11 Haobo Zhang , Yutao Zhu , Kelong Mao , Tianhao Li , Zhicheng Dou

The development of large language models and multi-modal models has enabled the appealing idea of generating novel molecules from text descriptions. Generative modeling would shift the paradigm from relying on large-scale chemical screening…

Machine Learning · Computer Science 2025-08-25 Yifan Deng , Spencer S. Ericksen , Anthony Gitter

Large Language Model (LLM) agents have demonstrated remarkable capabilities in organizing and executing complex tasks, and many such agents are now widely used in various application scenarios. However, developing these agents requires…

Artificial Intelligence · Computer Science 2025-10-01 Chenglin Yu , Yang Yu , Songmiao Wang , Yucheng Wang , Yifan Yang , Jinjia Li , Ming Li , Hongxia Yang

Large language models (LLMs) have demonstrated strong capabilities in language understanding and reasoning, yet they remain limited when tackling real-world tasks that require up-to-date knowledge, precise operations, or specialized tool…

Machine Learning · Computer Science 2025-09-17 Yabo Zhang , Yihan Zeng , Qingyun Li , Zhen Hu , Kavin Han , Wangmeng Zuo

The chemical reaction recommendation is to select proper reaction condition parameters for chemical reactions, which is pivotal to accelerating chemical science. With the rapid development of large language models (LLMs), there is growing…

Artificial Intelligence · Computer Science 2026-03-27 Cheng Yang , Jiaxuan Lu , Haiyuan Wan , Junchi Yu , Feiwei Qin

The integration of Large Language Models (LLMs) with specialized tools presents new opportunities for intelligent automation systems. However, orchestrating multiple LLM-driven agents to tackle complex tasks remains challenging due to…

Artificial Intelligence · Computer Science 2025-03-27 Pengfei Du

Agentic AI systems integrating large language models (LLMs) with reasoning and tooluse capabilities are transforming various domains - in particular, software development. In contrast, their application in chemical process flowsheet…

Artificial Intelligence · Computer Science 2026-03-16 Pascal Schäfer , Lukas J. Krinke , Martin Wlotzka , Norbert Asprion

Large Language Models (LLMs) have recently empowered agentic frameworks to exhibit advanced reasoning and planning capabilities. However, their integration in robotic control pipelines remains limited in two aspects: (1) prior…

Recent studies show that collaborating multiple large language model (LLM) powered agents is a promising way for task solving. However, current approaches are constrained by using a fixed number of agents and static communication…

Computation and Language · Computer Science 2024-11-18 Zijun Liu , Yanzhe Zhang , Peng Li , Yang Liu , Diyi Yang

In this study, we introduced a new benchmark consisting of a curated dataset and a defined evaluation process to assess the compositional reasoning capabilities of large language models within the chemistry domain. We designed and validated…

Computation and Language · Computer Science 2025-08-07 Mohammad Khodadad , Ali Shiraee Kasmaee , Mahdi Astaraki , Nicholas Sherck , Hamidreza Mahyar , Soheila Samiee

Although Multi-Agent Reinforcement Learning (MARL) is effective for complex multi-robot tasks, it suffers from low sample efficiency and requires iterative manual reward tuning. Large Language Models (LLMs) have shown promise in…

Robotics · Computer Science 2025-06-04 Guobin Zhu , Rui Zhou , Wenkang Ji , Shiyu Zhao

Large Language Model (LLM)-based multi-agent systems rely on optimized collaboration topologies to balance performance and communication costs. However, current methods struggle with the inherent stability-extensibility trade-off and often…

Multiagent Systems · Computer Science 2026-05-27 Xinkui Zhao , Sai Liu , Yifan Zhang , Qingyu Ma , Zewen Lin , Naibo Wang , Guanjie Cheng , Chang Liu , Yueshen Xu

The substantial data volumes encountered in modern particle physics and other domains of fundamental physics research allow (and require) the use of increasingly complex data analysis tools and workflows. While the use of machine learning…

High Energy Physics - Phenomenology · Physics 2026-02-18 Sascha Diefenbacher , Anna Hallin , Gregor Kasieczka , Michael Krämer , Anne Lauscher , Tim Lukas

Lead optimization in drug discovery requires improving therapeutic properties while ensuring that molecular modifications correspond to feasible synthetic routes. Existing approaches either prioritize property scores without enforcing…

Machine Learning · Computer Science 2026-05-04 Tao Li , Kaiyuan Hou , Tuan Vinh , Monika Raj , Zhichun Guo , Carl Yang

Despite their ability to understand chemical knowledge, large language models (LLMs) remain limited in their capacity to propose novel molecules with desired functions (e.g., drug-like properties). In addition, the molecules that LLMs…

Tool-augmented LLMs are a promising approach to create AI agents that can have realistic conversations, follow procedures, and call appropriate functions. However, evaluating them is challenging due to the diversity of possible…

Computation and Language · Computer Science 2024-10-11 Samuel Arcadinho , David Aparicio , Mariana Almeida

Large Language Models (LLMs) have become increasingly capable as tool-using agents, with benchmarks spanning diverse general agentic tasks. Yet rigorous evaluation of scientific tool use remains limited. In chemistry, recent agents can plan…

Artificial Intelligence · Computer Science 2026-05-11 Yuyang Wu , Yue Huang , Shuaike Shen , Xujian Wang , Shuhao Zhang , Qiyao Xue , Weichen Liu , Runtian Gao , Jian Ma , Xiangliang Zhang , Olexandr Isayev

Large Language Models (LLMs) have shown promising potential in the medical domain, assisting with tasks like clinical note generation and patient communication. However, current LLMs are limited to text-based communication, hindering their…

Computation and Language · Computer Science 2025-06-17 Yusheng Liao , Shuyang Jiang , Yanfeng Wang , Yu Wang

With the rise of large language models (LLMs), LLM agents capable of autonomous reasoning, planning, and executing complex tasks have become a frontier in artificial intelligence. However, how to translate the research on general agents…

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