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Multiple Instance Learning (MIL) is a cornerstone approach in computational pathology (CPath) for generating clinically meaningful slide-level embeddings from gigapixel tissue images. However, MIL often struggles with small, weakly…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Daniel Shao , Richard J. Chen , Andrew H. Song , Joel Runevic , Ming Y. Lu , Tong Ding , Faisal Mahmood

Conventional deep learning models have limited capacity in learning multiple tasks sequentially. The issue of forgetting the previously learned tasks in continual learning is known as catastrophic forgetting or interference. When the input…

Machine Learning · Computer Science 2020-07-14 Honglin Li , Payam Barnaghi , Shirin Enshaeifar , Frieder Ganz

Determining early-stage prognostic markers and stratifying patients for effective treatment are two key challenges for improving outcomes for melanoma patients. Previous studies have used tumour transcriptome data to stratify patients into…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Lucy Godson , Navid Alemi , Jeremie Nsengimana , Graham P. Cook , Emily L. Clarke , Darren Treanor , D. Timothy Bishop , Julia Newton-Bishop , Ali Gooya

Predicting breast cancer recurrence risk is a critical clinical challenge. This study investigates the potential of computational pathology to stratify patients using deep learning on routine Hematoxylin and Eosin (H&E) stained whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Jinqiu Chen , Huyan Xu

Machine learning models are becoming commonplace in the domain of medical imaging, and with these methods comes an ever-increasing need for more data. However, to preserve patient anonymity it is frequently impractical or prohibited to…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Samuel Remedios , Snehashis Roy , Justin Blaber , Camilo Bermudez , Vishwesh Nath , Mayur B. Patel , John A. Butman , Bennett A. Landman , Dzung L. Pham

Multiple instance learning (MIL) is a supervised learning methodology that aims to allow models to learn instance class labels from bag class labels, where a bag is defined to contain multiple instances. MIL is gaining traction for learning…

Computer Vision and Pattern Recognition · Computer Science 2019-11-14 Samuel W. Remedios , Zihao Wu , Camilo Bermudez , Cailey I. Kerley , Snehashis Roy , Mayur B. Patel , John A. Butman , Bennett A. Landman , Dzung L. Pham

Multiple Instance Learning is the predominant method for Whole Slide Image classification in digital pathology, enabling the use of slide-level labels to supervise model training. Although MIL eliminates the tedious fine-grained annotation…

Computer Vision and Pattern Recognition · Computer Science 2025-05-28 Chen Shu , Boyu Fu , Yiman Li , Ting Yin , Wenchuan Zhang , Jie Chen , Yuhao Yi , Hong Bu

Self-supervised learning has proven to be an effective way to learn representations in domains where annotated labels are scarce, such as medical imaging. A widely adopted framework for this purpose is contrastive learning and it has been…

Computer Vision and Pattern Recognition · Computer Science 2024-02-23 Hugo Figueiras , Helena Aidos , Nuno Cruz Garcia

Deep learning techniques have revolutionised medical imaging, improving diagnostic accuracy and enabling both more accurate and earlier disease detection. However, the relationship between pre-training strategies and downstream performance…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Felix Krones

Pretext-based self-supervised learning learns the semantic representation via a handcrafted pretext task over unlabeled data and then uses the learned representation for downstream tasks, which effectively reduces the sample complexity of…

Machine Learning · Computer Science 2022-02-24 Jiaye Teng , Weiran Huang , Haowei He

State-of-the-art deep learning approaches for skin lesion recognition often require pretraining on larger and more varied datasets, to overcome the generalization limitations derived from the reduced size of the skin lesion imaging…

Computer Vision and Pattern Recognition · Computer Science 2022-05-04 Kirill Sirotkin , Marcos Escudero-Viñolo , Pablo Carballeira , Juan Carlos SanMiguel

Recently, self-supervised representation learning gives further development in multimedia technology. Most existing self-supervised learning methods are applicable to packaged data. However, when it comes to streamed data, they are…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Zhiwei Lin , Yongtao Wang , Hongxiang Lin

We introduce an extension of the multi-instance learning problem where examples are organized as nested bags of instances (e.g., a document could be represented as a bag of sentences, which in turn are bags of words). This framework can be…

Machine Learning · Computer Science 2020-10-06 Alessandro Tibo , Manfred Jaeger , Paolo Frasconi

Timely and accurate lymphoma diagnosis is essential for guiding cancer treatment. Standard diagnostic practice combines hematoxylin and eosin (HE)-stained whole slide images with immunohistochemistry, flow cytometry, and molecular genetic…

The effective management of brain tumors relies on precise typing, subtyping, and grading. This study advances patient care with findings from rigorous multiple instance learning experimentations across various feature extractors and…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Ekansh Chauhan , Amit Sharma , Megha S Uppin , C. V. Jawahar , P. K. Vinod

Meta-learning considers the problem of learning an efficient learning process that can leverage its past experience to accurately solve new tasks. However, the efficacy of meta-learning crucially depends on the distribution of tasks…

Computation and Language · Computer Science 2021-11-03 Trapit Bansal , Karthick Gunasekaran , Tong Wang , Tsendsuren Munkhdalai , Andrew McCallum

Unsupervised learning has been a long-standing goal of machine learning and is especially important for medical image analysis, where the learning can compensate for the scarcity of labeled datasets. A promising subclass of unsupervised…

Image and Video Processing · Electrical Eng. & Systems 2021-09-09 Ozan Ciga , Tony Xu , Anne L. Martel

Supervised machine learning provides state-of-the-art solutions to a wide range of computer vision problems. However, the need for copious labelled training data limits the capabilities of these algorithms in scenarios where such input is…

Computer Vision and Pattern Recognition · Computer Science 2022-09-02 András Kalapos , Bálint Gyires-Tóth

In this work, we investigate multi-task learning as a way of pre-training models for classification tasks in digital pathology. It is motivated by the fact that many small and medium-size datasets have been released by the community over…

Image and Video Processing · Electrical Eng. & Systems 2020-05-19 Romain Mormont , Pierre Geurts , Raphaël Marée

Cell classification and counting in immunohistochemical cytoplasm staining images play a pivotal role in cancer diagnosis. Weakly supervised learning is a potential method to deal with labor-intensive labeling. However, the inconstant cell…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Shichuan Zhang , Chenglu Zhu , Honglin Li , Jiatong Cai , Lin Yang