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Model interpretability is crucial for establishing AI safety and clinician trust in medical applications for example, in survival modelling with competing risks. Recent deep learning models have attained very good predictive performance but…

Machine Learning · Computer Science 2026-01-26 Dhanesh Ramachandram , Anne Loefler , Surain Roberts , Amol Verma , Maia Norman , Fahad Razak , Conrad Pow , Charles de Mestral

Survival analysis is a fundamental tool for modeling time-to-event outcomes in healthcare. Recent advances have introduced flexible neural network approaches for improved predictive performance. However, most of these models do not provide…

Machine Learning · Statistics 2025-09-10 Mert Ketenci , Vincent Jeanselme , Harry Reyes Nieva , Shalmali Joshi , Noémie Elhadad

Survival analysis is widely used as a technique to model time-to-event data when some data is censored, particularly in healthcare for predicting future patient risk. In such settings, survival models must be both accurate and interpretable…

Machine Learning · Computer Science 2024-04-24 Mike Van Ness , Madeleine Udell

With increasing interest in applying machine learning to develop healthcare solutions, there is a desire to create interpretable deep learning models for survival analysis. In this paper, we extend the Neural Additive Model (NAM) by…

Machine Learning · Computer Science 2022-11-18 Matthew Peroni , Marharyta Kurban , Sun Young Yang , Young Sun Kim , Hae Yeon Kang , Ji Hyun Song

Deep neural networks (DNNs) are powerful black-box predictors that have achieved impressive performance on a wide variety of tasks. However, their accuracy comes at the cost of intelligibility: it is usually unclear how they make their…

Machine Learning · Computer Science 2021-10-26 Rishabh Agarwal , Levi Melnick , Nicholas Frosst , Xuezhou Zhang , Ben Lengerich , Rich Caruana , Geoffrey Hinton

Deep neural networks (DNNs) have shown exceptional performances in a wide range of tasks and have become the go-to method for problems requiring high-level predictive power. There has been extensive research on how DNNs arrive at their…

Machine Learning · Computer Science 2023-02-21 Mattias Luber , Anton Thielmann , Benjamin Säfken

Survival analysis in the presence of multiple possible adverse events, i.e., competing risks, is a pervasive problem in many industries (healthcare, finance, etc.). Since only one event is typically observed, the incidence of an event of…

Machine Learning · Computer Science 2018-08-20 Anton Nemchenko , Trent Kyono , Mihaela Van Der Schaar

When modelling competing risks survival data, several techniques have been proposed in both the statistical and machine learning literature. State-of-the-art methods have extended classical approaches with more flexible assumptions that can…

A new modification of the Neural Additive Model (NAM) called SurvNAM and its modifications are proposed to explain predictions of the black-box machine learning survival model. The method is based on applying the original NAM to solving the…

Machine Learning · Computer Science 2021-04-20 Lev V. Utkin , Egor D. Satyukov , Andrei V. Konstantinov

Demand forecasts are the crucial basis for numerous business decisions, ranging from inventory management to strategic facility planning. While machine learning (ML) approaches offer accuracy gains, their interpretability and acceptance are…

Machine Learning · Computer Science 2024-04-08 Leif Feddersen , Catherine Cleophas

Time series models with recurrent neural networks (RNNs) can have high accuracy but are unfortunately difficult to interpret as a result of feature-interactions, temporal-interactions, and non-linear transformations. Interpretability is…

Machine Learning · Computer Science 2021-09-17 Asif Rahman , Yale Chang , Jonathan Rubin

Time-to-event modelling, known as survival analysis, differs from standard regression as it addresses censoring in patients who do not experience the event of interest. Despite competitive performances in tackling this problem, machine…

Machine Learning · Computer Science 2023-05-12 Vincent Jeanselme , Chang Ho Yoon , Brian Tom , Jessica Barrett

Survival analysis, or time-to-event analysis, is an important and widespread problem in healthcare research. Medical research has traditionally relied on Cox models for survival analysis, due to their simplicity and interpretability. Cox…

Machine Learning · Computer Science 2023-10-25 Mike Van Ness , Tomas Bosschieter , Natasha Din , Andrew Ambrosy , Alexander Sandhu , Madeleine Udell

Neural Additive Models (NAMs) have recently demonstrated promising predictive performance while maintaining interpretability. However, their capacity is limited to capturing only first-order feature interactions, which restricts their…

Machine Learning · Computer Science 2025-11-17 Minkyu Kim , Hyun-Soo Choi , Jinho Kim

This paper introduces the Actuarial Neural Additive Model, an inherently interpretable deep learning model for general insurance pricing that offers fully transparent and interpretable results while retaining the strong predictive power of…

Machine Learning · Computer Science 2025-09-11 Patrick J. Laub , Tu Pho , Bernard Wong

Accurate and interpretable survival analysis remains a core challenge in oncology. With growing multimodal data and the clinical need for transparent models to support validation and trust, this challenge increases in complexity. We propose…

Artificial Intelligence · Computer Science 2025-09-29 Mafalda Malafaia , Peter A. N. Bosman , Coen Rasch , Tanja Alderliesten

Deep neural networks (DNNs) have proven to be highly effective in a variety of tasks, making them the go-to method for problems requiring high-level predictive power. Despite this success, the inner workings of DNNs are often not…

Machine Learning · Statistics 2024-03-04 Anton Thielmann , René-Marcel Kruse , Thomas Kneib , Benjamin Säfken

The Cox Proportional Hazards (CPH) model has long been the preferred survival model for its explainability. However, to increase its predictive power beyond its linear log-risk, it was extended to utilize deep neural networks, sacrificing…

Machine Learning · Computer Science 2025-12-02 Abdallah Alabdallah , Omar Hamed , Mattias Ohlsson , Thorsteinn Rögnvaldsson , Sepideh Pashami

We introduce the Functional Competing Risk Net (FCRN), a unified deep-learning framework for discrete-time survival analysis under competing risks, which seamlessly integrates functional covariates and handles missing data within an…

Machine Learning · Computer Science 2025-10-01 Penglei Gao , Yan Zou , Abhijit Duggal , Shuaiqi Huang , Faming Liang , Xiaofeng Wang

Neural additive model (NAM) is a recently proposed explainable artificial intelligence (XAI) method that utilizes neural network-based architectures. Given the advantages of neural networks, NAMs provide intuitive explanations for their…

Machine Learning · Computer Science 2024-11-12 Hoki Kim , Jinseong Park , Yujin Choi , Seungyun Lee , Jaewook Lee
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