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Large language models (LLMs) show promise for extracting clinically meaningful information from unstructured health records, yet their translation into real-world settings is constrained by the lack of scalable and trustworthy validation…

Large language models (LLMs) can generate fluent clinical summaries of remote therapeutic monitoring time series. However, it remains unclear whether these narratives faithfully capture clinically significant events, such as sustained…

Artificial Intelligence · Computer Science 2026-03-03 Aditya Shukla , Yining Yuan , Ben Tamo , Yifei Wang , Micky Nnamdi , Shaun Tan , Jieru Li , Benoit Marteau , Brad Willingham , May Wang

Alzheimer's disease (AD) is the fifth-leading cause of death among Americans aged 65 and older. Screening and early detection of AD and related dementias (ADRD) are critical for timely intervention and for identifying clinical trial…

Artificial Intelligence · Computer Science 2024-05-29 Jiankun Wang , Sumyeong Ahn , Taykhoom Dalal , Xiaodan Zhang , Weishen Pan , Qiannan Zhang , Bin Chen , Hiroko H. Dodge , Fei Wang , Jiayu Zhou

Despite the increasing demand for AI-based mental health monitoring tools, their practical utility for clinicians is limited by the lack of interpretability.The CLPsych 2024 Shared Task (Chim et al., 2024) aims to enhance the…

Computation and Language · Computer Science 2024-02-26 Hyolim Jeon , Dongje Yoo , Daeun Lee , Sejung Son , Seungbae Kim , Jinyoung Han

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

Recent advancements in large language models (LLMs) have revolutionized various domains, bringing significant progress and new opportunities. Despite progress in speech-related tasks, LLMs have not been sufficiently explored in multi-talker…

Computation and Language · Computer Science 2025-04-03 Lingwei Meng , Shujie Hu , Jiawen Kang , Zhaoqing Li , Yuejiao Wang , Wenxuan Wu , Xixin Wu , Xunying Liu , Helen Meng

Attention-Deficit/Hyperactivity Disorder (ADHD) is a challenging disorder to study due to its complex symptomatology and diverse contributing factors. To explore how we can gain deeper insights on this topic, we performed a network analysis…

Social and Information Networks · Computer Science 2025-04-16 Hakan T. Otal , Stephen V. Faraone , M. Abdullah Canbaz

Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…

Machine Learning · Computer Science 2021-08-03 Amish Mittal , Sourav Sahoo , Arnhav Datar , Juned Kadiwala , Hrithwik Shalu , Jimson Mathew

Large, publicly available clinical datasets have emerged as a novel resource for understanding disease heterogeneity and to explore personalization of therapy. These datasets are derived from data not originally collected for research…

Machine Learning · Computer Science 2025-08-14 Anish Narain , Ritam Majumdar , Nikita Narayanan , Dominic Marshall , Sonali Parbhoo

We investigate how agents built on pretrained large language models (LLMs) can learn target classification functions from labeled examples without parameter updates. While conventional approaches like fine-tuning are often costly,…

Computation and Language · Computer Science 2026-05-06 Jackson Hassell , Dan Zhang , Hannah Kim , Tom Mitchell , Estevam Hruschka

We propose a unified optimization framework that combines neural networks with dictionary learning to model complex interactions between resting state functional MRI and behavioral data. The dictionary learning objective decomposes patient…

Machine Learning · Computer Science 2024-11-21 Niharika Shimona D'Souza , Mary Beth Nebel , Nicholas Wymbs , Stewart Mostofsky , Archana Venkataraman

Large language models (LLMs) are increasingly used in decision-making tasks like r\'esum\'e screening and content moderation, giving them the power to amplify or suppress certain perspectives. While previous research has identified…

Computation and Language · Computer Science 2025-05-28 Naba Rizvi , Harper Strickland , Saleha Ahmedi , Aekta Kallepalli , Isha Khirwadkar , William Wu , Imani N. S. Munyaka , Nedjma Ousidhoum

Associative learning--forming links between co-occurring items--is fundamental to human cognition, reshaping internal representations in complex ways. Testing hypotheses on how representational changes occur in biological systems is…

Machine Learning · Computer Science 2025-10-27 Camila Kolling , Vy Ai Vo , Mariya Toneva

Large language models (LLMs) now support context windows of hundreds of thousands to millions of tokens, enabling applications such as long-document summarization, large-scale code synthesis, multi-document question answering and persistent…

Computation and Language · Computer Science 2025-10-22 Siyuan Yan , Guo-Qing Jiang , Yuchen Zhang , Xiaoxing Ma , Ran Zhu , Chun Cao , Jingwei Xu

Traditional Automated Speaking Assessment (ASA) systems exhibit inherent modality limitations: text-based approaches lack acoustic information while audio-based methods miss semantic context. Multimodal Large Language Models (MLLM) offer…

Computation and Language · Computer Science 2025-08-19 Yu-Hsuan Fang , Tien-Hong Lo , Yao-Ting Sung , Berlin Chen

Large language models (LLMs) have demonstrated exceptional proficiency in understanding and generating human language, but efficient inference on resource-constrained embedded devices remains challenging due to large model sizes and…

Hardware Architecture · Computer Science 2025-07-15 Weihong Xu , Haein Choi , Po-kai Hsu , Shimeng Yu , Tajana Rosing

Automated speaking assessment (ASA) on opinion expressions is often hampered by the scarcity of labeled recordings, which restricts prompt diversity and undermines scoring reliability. To address this challenge, we propose a novel training…

Computation and Language · Computer Science 2025-09-12 Chung-Chun Wang , Jhen-Ke Lin , Hao-Chien Lu , Hong-Yun Lin , Berlin Chen

Large Vision-Language Models (VLMs) have achieved remarkable success in multi-modal reasoning, but their inference time efficiency remains a significant challenge due to the memory overhead during decoding, especially when the query and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Fatih Ilhan , Gaowen Liu , Ramana Rao Kompella , Selim Furkan Tekin , Tiansheng Huang , Zachary Yahn , Yichang Xu , Ling Liu

Early and accurate detection of Alzheimer's disease (AD) remains a major challenge in medical diagnosis due to its subtle onset and progressive nature. This research introduces an explainable ensemble learning Framework designed to classify…

Machine Learning · Computer Science 2026-03-06 Nishan Mitra

Importance: Emergency department (ED) returns for mental health conditions pose a major healthcare burden, with 24-27% of patients returning within 30 days. Traditional machine learning models for predicting these returns often lack…