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Deriving disease subtypes from electronic health records (EHRs) can guide next-generation personalized medicine. However, challenges in summarizing and representing patient data prevent widespread practice of scalable EHR-based…

Increasing volume of Electronic Health Records (EHR) in recent years provides great opportunities for data scientists to collaborate on different aspects of healthcare research by applying advanced analytics to these EHR clinical data. A…

Machine Learning · Computer Science 2019-09-23 Najibesadat Sadati , Milad Zafar Nezhad , Ratna Babu Chinnam , Dongxiao Zhu

Increasing volume of Electronic Health Records (EHR) in recent years provides great opportunities for data scientists to collaborate on different aspects of healthcare research by applying advanced analytics to these EHR clinical data. A…

Machine Learning · Computer Science 2019-10-01 Najibesadat Sadati , Milad Zafar Nezhad , Ratna Babu Chinnam , Dongxiao Zhu

Patient similarity assessment (PSA) is pivotal to evidence-based and personalized medicine, enabled by analyzing the increasingly available electronic health records (EHRs). However, machine learning approaches for PSA has to deal with…

Machine Learning · Computer Science 2022-02-04 Xian Wei , See Kiong Ng , Tongtong Zhang , Yingjie Liu

Deep learning models exhibit state-of-the-art performance for many predictive healthcare tasks using electronic health records (EHR) data, but these models typically require training data volume that exceeds the capacity of most healthcare…

Machine Learning · Computer Science 2018-10-24 Edward Choi , Cao Xiao , Walter F. Stewart , Jimeng Sun

Multi-institutional electronic health record (Multi-EHR) data have emerged as a powerful resource for developing predictive models to support clinical decisions and for generating reliable real-world evidence. By aggregating information…

Methodology · Statistics 2026-05-12 Yuming Zhang , Congyuan Duan , Dong Xia , Doudou Zhou , Tianxi Cai

Predictive modeling with electronic health record (EHR) data is anticipated to drive personalized medicine and improve healthcare quality. Constructing predictive statistical models typically requires extraction of curated predictor…

The rapid expansion of large-scale electronic health record (EHR) data offers unique opportunities to improve the accuracy and efficiency of clinical risk estimation. Yet, because clinical events may occur outside the recording health…

Methodology · Statistics 2026-05-11 Jie Zhou , Enhao Wang , Xuan Wang

Distributed representations of medical concepts have been used to support downstream clinical tasks recently. Electronic Health Records (EHR) capture different aspects of patients' hospital encounters and serve as a rich source for…

Computation and Language · Computer Science 2020-01-07 Shaika Chowdhury , Chenwei Zhang , Philip S. Yu , Yuan Luo

Electronic Health Records (EHR) data, a rich source for biomedical research, have been successfully used to gain novel insight into a wide range of diseases. Despite its potential, EHR is currently underutilized for discovery research due…

Methodology · Statistics 2021-09-14 Yichi Zhang , Molei Liu , Matey Neykov , Tianxi Cai

We consider the problem of estimating the average treatment effect (ATE) in a semi-supervised learning setting, where a very small proportion of the entire set of observations are labeled with the true outcome but features predictive of the…

Methodology · Statistics 2020-10-27 David Cheng , Ashwin Ananthakrishnan , Tianxi Cai

Deep learning models have shown tremendous potential in learning representations, which are able to capture some key properties of the data. This makes them great candidates for transfer learning: Exploiting commonalities between different…

Extracting actionable insight from Electronic Health Records (EHRs) poses several challenges for traditional machine learning approaches. Patients are often missing data relative to each other; the data comes in a variety of modalities,…

Machine Learning · Computer Science 2018-11-13 Brandon Malone , Alberto Garcia-Duran , Mathias Niepert

A notable challenge of leveraging Electronic Health Records (EHR) for treatment effect assessment is the lack of precise information on important clinical variables, including the treatment received and the response. Both treatment…

Methodology · Statistics 2021-10-26 Jue Hou , Rajarshi Mukherjee , Tianxi Cai

Electronic Health Records (EHR) are generated from clinical routine care recording valuable information of broad patient populations, which provide plentiful opportunities for improving patient management and intervention strategies in…

Machine Learning · Computer Science 2023-04-13 Changshuo Liu , Wenqiao Zhang , Beng Chin Ooi , James Wei Luen Yip , Lingze Zeng , Kaiping Zheng

Patient representation learning refers to learning a dense mathematical representation of a patient that encodes meaningful information from Electronic Health Records (EHRs). This is generally performed using advanced deep learning methods.…

Machine Learning · Computer Science 2021-01-26 Yuqi Si , Jingcheng Du , Zhao Li , Xiaoqian Jiang , Timothy Miller , Fei Wang , W. Jim Zheng , Kirk Roberts

Automatic representation learning of key entities in electronic health record (EHR) data is a critical step for healthcare informatics that turns heterogeneous medical records into structured and actionable information. Here we propose…

Machine Learning · Computer Science 2019-10-08 Tong Wu , Yunlong Wang , Yue Wang , Emily Zhao , Yilian Yuan , Zhi Yang

In electronic health records (EHRs), clustering patients and distinguishing disease subtypes are key tasks to elucidate pathophysiology and aid clinical decision-making. However, clustering in healthcare informatics is still based on…

Machine Learning · Computer Science 2026-04-09 Manar D. Samad , Yina Hou , Shrabani Ghosh

Effective modeling of electronic health records presents many challenges as they contain large amounts of irregularity most of which are due to the varying procedures and diagnosis a patient may have. Despite the recent progress in machine…

Machine Learning · Computer Science 2019-10-07 Sajad Darabi , Mohammad Kachuee , Majid Sarrafzadeh

Electronic Health Records (EHRs) contain a wealth of patient data; however, the sparsity of EHRs data often presents significant challenges for predictive modeling. Conventional imputation methods inadequately distinguish between real and…

Machine Learning · Computer Science 2025-02-27 Yinghao Zhu , Zixiang Wang , Long He , Shiyun Xie , Xiaochen Zheng , Liantao Ma , Chengwei Pan
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