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Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

Computation and Language · Computer Science 2025-04-24 Gilchan Park , Byung-Jun Yoon , Xihaier Luo , Vanessa López-Marrero , Shinjae Yoo , Shantenu Jha

Large language models (LLMs) exhibit remarkable generative capabilities but often suffer from hallucinations. Retrieval-augmented generation (RAG) offers an effective solution by incorporating external knowledge, but existing methods still…

Computation and Language · Computer Science 2024-12-17 Xiaoxi Li , Jiajie Jin , Yujia Zhou , Yongkang Wu , Zhonghua Li , Qi Ye , Zhicheng Dou

This critical review provides an in-depth analysis of Large Language Models (LLMs), encompassing their foundational principles, diverse applications, and advanced training methodologies. We critically examine the evolution from Recurrent…

Artificial Intelligence · Computer Science 2025-09-29 Milad Moradi , Ke Yan , David Colwell , Matthias Samwald , Rhona Asgari

The ability of large language models to generate complex texts allows them to be widely integrated into many aspects of life, and their output can quickly fill all network resources. As the impact of LLMs grows, it becomes increasingly…

Computation and Language · Computer Science 2024-11-12 Yongye Su , Yuqing Wu

Large language models (LLMs) encapsulate a vast amount of factual information within their pre-trained weights, as evidenced by their ability to answer diverse questions across different domains. However, this knowledge is inherently…

Artificial Intelligence · Computer Science 2024-01-31 Oded Ovadia , Menachem Brief , Moshik Mishaeli , Oren Elisha

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

Text-to-SQL aims at generating SQL queries for the given natural language questions and thus helping users to query databases. Prompt learning with large language models (LLMs) has emerged as a recent approach, which designs prompts to lead…

Information Retrieval · Computer Science 2023-09-06 Chunxi Guo , Zhiliang Tian , Jintao Tang , Shasha Li , Zhihua Wen , Kaixuan Wang , Ting Wang

Large language models (LLMs) have demonstrated their ability to learn in-context, allowing them to perform various tasks based on a few input-output examples. However, the effectiveness of in-context learning is heavily reliant on the…

Computation and Language · Computer Science 2024-01-29 Liang Wang , Nan Yang , Furu Wei

Extracting MITRE ATT\&CK Tactics, Techniques, and Procedures (TTPs) from natural language threat reports is crucial yet challenging. Existing methods primarily focus on performance metrics using data-driven approaches, often neglecting…

Cryptography and Security · Computer Science 2025-05-15 Cheng Meng , ZhengWei Jiang , QiuYun Wang , XinYi Li , ChunYan Ma , FangMing Dong , FangLi Ren , BaoXu Liu

Current protein language models (PLMs) learn protein representations mainly based on their sequences, thereby well capturing co-evolutionary information, but they are unable to explicitly acquire protein functions, which is the end goal of…

Biomolecules · Quantitative Biology 2023-07-06 Minghao Xu , Xinyu Yuan , Santiago Miret , Jian Tang

Understanding protein sequences is vital and urgent for biology, healthcare, and medicine. Labeling approaches are expensive yet time-consuming, while the amount of unlabeled data is increasing quite faster than that of the labeled data due…

Computation and Language · Computer Science 2021-11-01 Liang He , Shizhuo Zhang , Lijun Wu , Huanhuan Xia , Fusong Ju , He Zhang , Siyuan Liu , Yingce Xia , Jianwei Zhu , Pan Deng , Bin Shao , Tao Qin , Tie-Yan Liu

Large Language Models (LLMs) are known for their expensive and time-consuming training. Thus, oftentimes, LLMs are fine-tuned to address a specific task, given the pretrained weights of a pre-trained LLM considered a foundation model. In…

Computation and Language · Computer Science 2025-12-05 Eshed Gal , Moshe Eliasof , Javier Turek , Uri Ascher , Eran Treister , Eldad Haber

The increasing adoption of large language models (LLMs) has raised serious concerns about their reliability and trustworthiness. As a result, a growing body of research focuses on evidence-based text generation with LLMs, aiming to link…

Computation and Language · Computer Science 2026-04-17 Tobias Schreieder , Tim Schopf , Michael Färber

Retrieval-augmented language models (LMs) have received much attention recently. However, typically the retriever is not trained jointly as a native component of the LM, but added post-hoc to an already-pretrained LM, which limits the…

Computation and Language · Computer Science 2024-07-23 Ohad Rubin , Jonathan Berant

Conventional predictive modeling of parametric relationships in manufacturing processes is limited by the subjectivity of human expertise and intuition on the one hand and by the cost and time of experimental data generation on the other…

Computation and Language · Computer Science 2025-06-26 Kiarash Naghavi Khanghah , Anandkumar Patel , Rajiv Malhotra , Hongyi Xu

Pre-trained language model (PTM) has been shown to yield powerful text representations for dense passage retrieval task. The Masked Language Modeling (MLM) is a major sub-task of the pre-training process. However, we found that the…

Computation and Language · Computer Science 2022-10-28 Dingkun Long , Yanzhao Zhang , Guangwei Xu , Pengjun Xie

Existing benchmarks for evaluating mathematical reasoning in large language models (LLMs) rely primarily on competition problems, formal proofs, or artificially challenging questions -- failing to capture the nature of mathematics…

Artificial Intelligence · Computer Science 2025-10-21 Jie Zhang , Cezara Petrui , Kristina Nikolić , Florian Tramèr

As more content generated by large language models (LLMs) floods into the Internet, information retrieval (IR) systems now face the challenge of distinguishing and handling a blend of human-authored and machine-generated texts. Recent…

Information Retrieval · Computer Science 2025-08-26 Wei Huang , Keping Bi , Yinqiong Cai , Wei Chen , Jiafeng Guo , Xueqi Cheng

In recent times training Language Models (LMs) have relied on computationally heavy training over massive datasets which makes this training process extremely laborious. In this paper we propose a novel method for numerically evaluating…

The rapid development of large language models (LLMs), like ChatGPT, has resulted in the widespread presence of LLM-generated content on social media platforms, raising concerns about misinformation, data biases, and privacy violations,…

Computation and Language · Computer Science 2025-02-07 Zihao Cheng , Li Zhou , Feng Jiang , Benyou Wang , Haizhou Li
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