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Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Medical conversational AI (AI) plays a pivotal role in the development of safer and more effective medical dialogue systems. However, existing benchmarks and evaluation frameworks for assessing the information-gathering and diagnostic…

Computation and Language · Computer Science 2026-01-08 Lecheng Gong , Weimin Fang , Ting Yang , Dongjie Tao , Chunxiao Guo , Peng Wei , Bo Xie , Jinqun Guan , Zixiao Chen , Fang Shi , Jinjie Gu , Junwei Liu

Electronic Health Records (EHRs) are relational databases that store the entire medical histories of patients within hospitals. They record numerous aspects of patients' medical care, from hospital admission and diagnosis to treatment and…

Computation and Language · Computer Science 2024-05-24 Gyubok Lee , Sunjun Kweon , Seongsu Bae , Edward Choi

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

Computation and Language · Computer Science 2025-03-11 Pengcheng Qiu , Chaoyi Wu , Shuyu Liu , Weike Zhao , Zhuoxia Chen , Hongfei Gu , Chuanjin Peng , Ya Zhang , Yanfeng Wang , Weidi Xie

Text-to-SQL generation aims to translate natural language questions into SQL statements. In Text-to-SQL based on large language models, schema linking is a widely adopted strategy to streamline the input for LLMs by selecting only relevant…

Computation and Language · Computer Science 2024-11-27 Zhenbiao Cao , Yuanlei Zheng , Zhihao Fan , Xiaojin Zhang , Wei Chen , Xiang Bai

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

The Text-to-SQL task translates natural language questions into SQL queries, enabling intuitive database interaction for non-experts. While recent methods leveraging Large Language Models (LLMs) achieve strong performance, their reliance on…

Computation and Language · Computer Science 2026-01-21 Shengmin Piao , Jieun Lee , Sanghyun Park

Medical tasks such as diagnosis and treatment planning require precise and complex reasoning, particularly in life-critical domains. Unlike mathematical reasoning, medical reasoning demands meticulous, verifiable thought processes to ensure…

Computation and Language · Computer Science 2025-04-08 Juncheng Wu , Wenlong Deng , Xingxuan Li , Sheng Liu , Taomian Mi , Yifan Peng , Ziyang Xu , Yi Liu , Hyunjin Cho , Chang-In Choi , Yihan Cao , Hui Ren , Xiang Li , Xiaoxiao Li , Yuyin Zhou

Variant and gene interpretation are fundamental to personalized medicine and translational biomedicine. However, traditional approaches are manual and labor-intensive. Generative language models (LMs) can facilitate this process,…

Artificial Intelligence · Computer Science 2025-10-15 Owen Queen , Harrison G. Zhang , James Zou

Large Language Models (LLMs) are increasingly capable of generating complete applications from natural language instructions, creating new opportunities in science and education. In these domains, interactive scientific demonstrations are…

Software Engineering · Computer Science 2026-05-21 Qiaosheng Chen , Yang Liu , Lei Li , Kai Chen , Qipeng Guo , Gong Cheng , Fei Yuan

Evaluating large language models (LLMs) in the biomedical domain requires benchmarks that can distinguish reasoning from pattern matching and remain discriminative as model capabilities improve. Existing biomedical question answering (QA)…

The sheer volume of scientific experimental results and complex technical statements, often presented in tabular formats, presents a formidable barrier to individuals acquiring preferred information. The realms of scientific reasoning and…

Computation and Language · Computer Science 2024-03-28 Zhixin Guo , Jianping Zhou , Jiexing Qi , Mingxuan Yan , Ziwei He , Guanjie Zheng , Zhouhan Lin , Xinbing Wang , Chenghu Zhou

The injection of domain-specific knowledge is crucial for adapting language models (LMs) to specialized fields such as biomedicine. While most current approaches rely on unstructured text corpora, this study explores two complementary…

Computation and Language · Computer Science 2026-04-21 Jaafer Klila , Sondes Bannour Souihi , Rahma Boujelben , Nasredine Semmar , Lamia Hadrich Belguith

The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination,…

Artificial Intelligence · Computer Science 2026-02-12 Zhiling Yan , Dingjie Song , Zhe Fang , Yisheng Ji , Xiang Li , Quanzheng Li , Lichao Sun

Recent text-to-SQL systems powered by large language models (LLMs) have demonstrated remarkable performance in translating natural language queries into SQL. However, these systems often struggle with complex database structures and…

Computation and Language · Computer Science 2025-05-22 Haoyuan Ma , Yongliang Shen , Hengwei Liu , Wenqi Zhang , Haolei Xu , Qiuying Peng , Jun Wang , Weiming Lu

Recognizing the promise of natural language interfaces to databases, prior studies have emphasized the development of text-to-SQL systems. While substantial progress has been made in this field, existing research has concentrated on…

Recent In-Context Learning based methods have achieved remarkable success in Text-to-SQL task. However, there is still a large gap between the performance of these models and human performance on datasets with complex database schema and…

Computation and Language · Computer Science 2024-11-08 Wenxuan Xie , Gaochen Wu , Bowen Zhou

Multimodal Large Language Models (LLMs) hold promise for biomedical reasoning, but current benchmarks fail to capture the complexity of real-world clinical workflows. Existing evaluations primarily assess unimodal, decontextualized…

Text-to-SQL translates natural language queries into Structured Query Language (SQL) commands, enabling users to interact with databases using natural language. Essentially, the text-to-SQL task is a text generation task, and its…

Databases · Computer Science 2024-10-10 Xiaohu Zhu , Qian Li , Lizhen Cui , Yongkang Liu