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Related papers: Transformers in Protein: A Survey

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A protein's function depends critically on its conformational ensemble, a collection of energy weighted structures whose balance depends on temperature and environment. Though recent deep learning (DL) methods have substantially advanced…

Biomolecules · Quantitative Biology 2026-01-09 Myeongsang Lee , Lauren L. Porter

Protein mutations can have profound effects on biological function, making accurate prediction of property changes critical for drug discovery, protein engineering, and precision medicine. Current approaches rely on fine-tuning…

Machine Learning · Computer Science 2025-10-27 Srivathsan Badrinarayanan , Yue Su , Janghoon Ock , Alan Pham , Sanya Ahuja , Amir Barati Farimani

Transformers have become the foundational architecture for a broad spectrum of sequence modeling applications, underpinning state-of-the-art systems in natural language processing, vision, and beyond. However, their theoretical limitations…

Computation and Language · Computer Science 2026-02-13 Michelle Yuan , Weiyi Sun , Amir H. Rezaeian , Jyotika Singh , Sandip Ghoshal , Yao-Ting Wang , Miguel Ballesteros , Yassine Benajiba

Proteins are the fundamental macromolecules that play diverse and crucial roles in all living matter and have tremendous implications in healthcare, manufacturing, and biotechnology. Their functions are largely determined by the sequences…

Biomolecules · Quantitative Biology 2024-09-17 Boqiao Lai

Prediction of protein structures using computational approaches has been explored for over two decades, paving a way for more focused research and development of algorithms in comparative modelling, ab intio modelling and structure…

Quantitative Methods · Quantitative Biology 2020-05-19 Surbhi Dhingra , Ramanathan Sowdhamini , Frédéric Cadet , Bernard Offmann

Tabular data remains one of the most prevalent data types across a wide range of real-world applications, yet effective representation learning for this domain poses unique challenges due to its irregular patterns, heterogeneous feature…

Machine Learning · Computer Science 2025-01-08 Weijieying Ren , Tianxiang Zhao , Yuqing Huang , Vasant Honavar

Transformers have significantly impacted domains like natural language processing, computer vision, and robotics, where they improve performance compared to other neural networks. This survey explores how transformers are used in…

Machine Learning · Computer Science 2023-07-13 Pranav Agarwal , Aamer Abdul Rahman , Pierre-Luc St-Charles , Simon J. D. Prince , Samira Ebrahimi Kahou

Transformers are crucial across many AI fields, such as large language models, computer vision, and reinforcement learning. This prominence stems from the architecture's perceived universality and scalability compared to alternatives. This…

Machine Learning · Computer Science 2025-12-23 Amirreza Abbasi , Mohsen Hooshmand

Vision transformers are emerging as a powerful tool to solve computer vision problems. Recent techniques have also proven the efficacy of transformers beyond the image domain to solve numerous video-related tasks. Among those, human action…

Computer Vision and Pattern Recognition · Computer Science 2022-09-14 Anwaar Ulhaq , Naveed Akhtar , Ganna Pogrebna , Ajmal Mian

Protein function prediction is a crucial task in bioinformatics, with significant implications for understanding biological processes and disease mechanisms. While the relationship between sequence and function has been extensively…

Quantitative Methods · Quantitative Biology 2024-09-04 Shania Mitra , Lei Huang , Manolis Kellis

Composed of amino acid chains that influence how they fold and thus dictating their function and features, proteins are a class of macromolecules that play a central role in major biological processes and are required for the structure,…

Quantitative Methods · Quantitative Biology 2022-07-15 Aaron Wang

Retrosynthesis prediction is one of the fundamental challenges in organic synthesis. The task is to predict the reactants given a core product. With the advancement of machine learning, computer-aided synthesis planning has gained…

Chemical Physics · Physics 2022-02-01 Yue Wan , Benben Liao , Chang-Yu Hsieh , Shengyu Zhang

Transformer architecture has widespread applications, particularly in Natural Language Processing and computer vision. Recently Transformers have been employed in various aspects of time-series analysis. This tutorial provides an overview…

Machine Learning · Computer Science 2023-07-27 Sabeen Ahmed , Ian E. Nielsen , Aakash Tripathi , Shamoon Siddiqui , Ghulam Rasool , Ravi P. Ramachandran

The transformer is a neural network component that can be used to learn useful representations of sequences or sets of data-points. The transformer has driven recent advances in natural language processing, computer vision, and…

Machine Learning · Computer Science 2026-01-21 Richard E. Turner

Transformer, the latest technological advance of deep learning, has gained prevalence in natural language processing or computer vision. Since medical imaging bear some resemblance to computer vision, it is natural to inquire about the…

Computer Vision and Pattern Recognition · Computer Science 2022-11-22 Jun Li , Junyu Chen , Yucheng Tang , Ce Wang , Bennett A. Landman , S. Kevin Zhou

Protein structure prediction is pivotal for understanding the structure-function relationship of proteins, advancing biological research, and facilitating pharmaceutical development and experimental design. While deep learning methods and…

Machine Learning · Computer Science 2024-12-30 Kaihui Cheng , Ce Liu , Qingkun Su , Jun Wang , Liwei Zhang , Yining Tang , Yao Yao , Siyu Zhu , Yuan Qi

The Transformer architecture has revolutionized the field of sequence modeling and underpins the recent breakthroughs in large language models (LLMs). However, a comprehensive mathematical theory that explains its structure and operations…

Machine Learning · Computer Science 2026-04-14 Xue-Cheng Tai , Hao Liu , Lingfeng Li , Raymond H. Chan

Molecular Property Prediction (MPP) is vital for drug discovery, crop protection, and environmental science. Over the last decades, diverse computational techniques have been developed, from using simple physical and chemical properties and…

Machine Learning · Computer Science 2024-04-08 Afnan Sultan , Jochen Sieg , Miriam Mathea , Andrea Volkamer

Inferring the structural properties of a protein from its amino acid sequence is a challenging yet important problem in biology. Structures are not known for the vast majority of protein sequences, but structure is critical for…

Machine Learning · Computer Science 2019-10-17 Tristan Bepler , Bonnie Berger

Learning from 3D protein structures has gained wide interest in protein modeling and structural bioinformatics. Unfortunately, the number of available structures is orders of magnitude lower than the training data sizes commonly used in…

Biomolecules · Quantitative Biology 2022-06-01 Pedro Hermosilla , Timo Ropinski