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Diffusion models (DMs) represent state-of-the-art generative models for continuous inputs. DMs work by constructing a Stochastic Differential Equation (SDE) in the input space (ie, position space), and using a neural network to reverse it.…

Machine Learning · Computer Science 2024-05-14 Tianrong Chen , Jiatao Gu , Laurent Dinh , Evangelos A. Theodorou , Joshua Susskind , Shuangfei Zhai

Deep generative models such as diffusion and flow matching are powerful machine learning tools capable of learning and sampling from high-dimensional distributions. They are particularly useful when the training data appears to be…

High Energy Physics - Phenomenology · Physics 2026-04-30 Zachary Bogorad , Ibrahim Elsharkawy , Yonatan Kahn , Andrew J. Larkoski , Noam Levi

In addressing the challenge of Crystal Structure Prediction (CSP), symmetry-aware deep learning models, particularly diffusion models, have been extensively studied, which treat CSP as a conditional generation task. However, ensuring…

Materials Science · Physics 2025-12-09 Peijia Lin , Pin Chen , Rui Jiao , Qing Mo , Jianhuan Cen , Wenbing Huang , Yang Liu , Dan Huang , Yutong Lu

It is well known that deep generative models have a rich latent space, and that it is possible to smoothly manipulate their outputs by traversing this latent space. Recently, architectures have emerged that allow for more complex…

Machine Learning · Computer Science 2019-12-06 Andrew Gambardella , Atılım Güneş Baydin , Philip H. S. Torr

In many real-world applications of regression, conditional probability estimation, and uncertainty quantification, exploiting symmetries rooted in physics or geometry can dramatically improve generalization and sample efficiency. While…

Machine Learning · Computer Science 2025-05-28 Daniel Ordoñez-Apraez , Vladimir Kostić , Alek Fröhlich , Vivien Brandt , Karim Lounici , Massimiliano Pontil

Recently, combinations of generative and Bayesian machine learning have been introduced in particle physics for both fast detector simulation and inference tasks. These neural networks aim to quantify the uncertainty on the generated…

Machine Learning · Computer Science 2024-11-21 Sebastian Bieringer , Sascha Diefenbacher , Gregor Kasieczka , Mathias Trabs

We address the problem of improving the performance and in particular the sample complexity of deep neural networks by enforcing and guaranteeing invariances to symmetry transformations rather than learning them from data. Group-equivariant…

Machine Learning · Computer Science 2023-03-06 Matthias Rath , Alexandru Paul Condurache

Forecasting neural activity in response to naturalistic stimuli remains a key challenge for understanding brain dynamics and enabling downstream neurotechnological applications. Here, we introduce a generative forecasting framework for…

Neurons and Cognition · Quantitative Biology 2026-04-14 Nicole Rogalla , Yuzhen Qin , Mario Senden , Ahmed El-Gazzar , Marcel van Gerven

Deep generative models have achieved tremendous success in structure-based drug design in recent years, especially for generating 3D ligand molecules that bind to specific protein pocket. Notably, diffusion models have transformed ligand…

Machine Learning · Computer Science 2024-12-03 Daiheng Zhang , Chengyue Gong , Qiang Liu

We study the problem of how to distribute the training of large-scale deep learning models in the parallel computing environment. We propose a new distributed stochastic optimization method called Elastic Averaging SGD (EASGD). We analyze…

Machine Learning · Computer Science 2016-05-10 Sixin Zhang

This paper proposes a novel method, Explicit Flow Matching (ExFM), for training and analyzing flow-based generative models. ExFM leverages a theoretically grounded loss function, ExFM loss (a tractable form of Flow Matching (FM) loss), to…

Machine Learning · Computer Science 2024-07-03 Gleb Ryzhakov , Svetlana Pavlova , Egor Sevriugov , Ivan Oseledets

Recent hybrid models combining Linear State Space Models (SSMs) with self-attention mechanisms have demonstrated impressive results across a range of sequence modeling tasks. However, current approaches apply attention modules statically…

Machine Learning · Computer Science 2023-11-07 Liliang Ren , Yang Liu , Shuohang Wang , Yichong Xu , Chenguang Zhu , ChengXiang Zhai

Generative Flow Networks (GFlowNets) offer a powerful framework for sampling graphs in proportion to their rewards. However, existing approaches suffer from systematic biases due to inaccuracies in state transition probability computations.…

Machine Learning · Statistics 2025-10-17 Hohyun Kim , Seunggeun Lee , Min-hwan Oh

Although there has been a rapid development of practical applications, theoretical explanations of deep learning are in their infancy. Deep learning performs a sophisticated coarse graining. Since coarse graining is a key ingredient of the…

Machine Learning · Computer Science 2020-06-11 Ellen de Mello Koch , Robert de Mello Koch , Ling Cheng

Predicting low-energy molecular conformations given a molecular graph is an important but challenging task in computational drug discovery. Existing state-of-the-art approaches either resort to large scale transformer-based models that…

Quantitative Methods · Quantitative Biology 2024-10-31 Majdi Hassan , Nikhil Shenoy , Jungyoon Lee , Hannes Stark , Stephan Thaler , Dominique Beaini

It is well-known that stochastic gradient noise (SGN) acts as implicit regularization for deep learning and is essentially important for both optimization and generalization of deep networks. Some works attempted to artificially simulate…

Machine Learning · Computer Science 2022-08-31 Zeke Xie , Li Yuan , Zhanxing Zhu , Masashi Sugiyama

Equivariant and invariant deep learning models have been developed to exploit intrinsic symmetries in data, demonstrating significant effectiveness in certain scenarios. However, these methods often suffer from limited representation…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Yulu Bai , Jiahong Fu , Qi Xie , Deyu Meng

With deep learning gaining attention from the research community for prediction and control of real physical systems, learning important representations is becoming now more than ever mandatory. It is of extreme importance that deep…

Machine Learning · Computer Science 2022-04-13 Saul Santos , Monica Ekal , Rodrigo Ventura

Recognizing symmetries in data allows for significant boosts in neural network training. In many cases, however, the underlying symmetry is present only in an idealized dataset, and is broken in the training data, due to effects such as…

High Energy Physics - Experiment · Physics 2023-11-13 Edmund Witkowski , Daniel Whiteson

In this work, we introduce a new class of neural network operators designed to handle problems where memory effects and randomness play a central role. In this work, we introduce a new class of neural network operators designed to handle…

Machine Learning · Computer Science 2025-05-22 Rômulo Damasclin Chaves dos Santos , Jorge Henrique de Oliveira Sales