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Large parallel gains in the development of both computational resources as well as sampling methods have now made it possible to simulate dissociation events in ligand-protein complexes with all--atom resolution. Such encouraging progress,…

Molecular Dynamics (MD) is crucial in various fields such as materials science, chemistry, and pharmacology to name a few. Conventional MD software struggles with the balance between time cost and prediction accuracy, which restricts its…

Chemical Physics · Physics 2024-12-05 Ziyang Yu , Wenbing Huang , Yang Liu

Unlike most static material properties widely studied in the machine learning literature, ionic transport properties are inherently dynamic, making their fast and accurate prediction from static atomic structures challenging. The current…

Machine Learning · Computer Science 2026-05-12 Jiyeon Kim , Byungju Lee , Won-Yong Shin

Reliable numerical computation of quantum dynamics is a fundamental challenge when the long-ranged quantum entanglement plays essential roles as in the cases governed by quantum criticality in strongly correlated systems. Here we apply a…

Quantum Physics · Physics 2025-01-24 Ryui Kaneko , Masatoshi Imada , Yoshiyuki Kabashima , Tomi Ohtsuki

Integration of physics principles with data-driven methods has attracted great attention in recent few years. In this study, a physics-informed dynamic mode decomposition (piDMD) method, where the mass conservation law is integrated with a…

Fluid Dynamics · Physics 2023-11-07 Dandan Li , Bidan Zhao , Shuai Lu , Junwu Wang

Machine learning potentials have emerged as a means to enhance the accuracy of biomolecular simulations. However, their application is constrained by the significant computational cost arising from the vast number of parameters compared to…

Molecular dynamics simulations are a cornerstone in science, allowing to investigate from the system's thermodynamics to analyse intricate molecular interactions. In general, to create extended molecular trajectories can be a…

Computational Physics · Physics 2022-06-22 Ludwig Winkler , Klaus-Robert Müller , Huziel E. Sauceda

We push the boundaries of electronic structure-based \textit{ab-initio} molecular dynamics (AIMD) beyond 100 million atoms. This scale is otherwise barely reachable with classical force-field methods or novel neural network and machine…

In Molecular Dynamics (MD), the forces applied to atoms derive from potentials which describe the energy of bonds, valence angles, torsion angles, and Lennard-Jones interactions of which molecules are made. These de finitions are classic;…

Statistical Mechanics · Physics 2014-01-07 Bernard Monasse , Frédéric Boussinot

Neural network-based molecular dynamics (NNMD) simulations incorporating long-range electrostatic interactions have significantly extended the applicability to heterogeneous and ionic systems, enabling effective modeling critical physical…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-04-23 Jianxiong Li , Beining Zhang , Mingzhen Li , Siyu Hu , Jinzhe Zeng , Lijun Liu , Guojun Yuan , Zhan Wang , Guangming Tan , Weile Jia

The analysis of the damage on plasma facing materials (PFM), due to its direct interaction with the plasma environment, is needed to build the next generation of nuclear machines, where tungsten has been proposed as a candidate. In this…

Materials Science · Physics 2019-10-29 F. J. Domínguez-Gutiérrez , J Byggmästar , K. Nordlund , F. Djurabekova , U von Toussaint

Molecular dynamics (MD) simulations provide atomistic insights into the structure, dynamics, and function of biomolecules by generating time-resolved, high-dimensional trajectories. Analyzing such data benefits from estimating the minimal…

Biomolecules · Quantitative Biology 2026-03-02 Irene Cazzaniga , Toni Giorgino

Human motion prediction is essential for the safe and smooth operation of mobile service robots and intelligent vehicles around people. Commonly used neural network-based approaches often require large amounts of complete trajectories to…

Robotics · Computer Science 2023-06-07 Yufei Zhu , Andrey Rudenko , Tomasz P. Kucner , Achim J. Lilienthal , Martin Magnusson

Rigid bodies, made of smaller composite beads, are commonly used to simulate anisotropic particles with molecular dynamics or Monte Carlo methods. To accurately represent the particle shape and to obtain smooth and realistic effective pair…

Soft Condensed Matter · Physics 2024-02-20 B. Rusen Argun , Yu Fu , Antonia Statt

To address the computational challenges of ab initio molecular dynamics and the accuracy limitations of empirical force fields, the introduction of machine learning force fields has proven effective in various systems including metals and…

Soft Condensed Matter · Physics 2023-12-18 Junbao Hu , Liyang Zhou , Jian Jiang

Molecular dynamics (MD) simulation is essential for various scientific domains but computationally expensive. Learning-based force fields have made significant progress in accelerating ab-initio MD simulation but are not fast enough for…

Machine Learning · Computer Science 2023-08-29 Xiang Fu , Tian Xie , Nathan J. Rebello , Bradley D. Olsen , Tommi Jaakkola

The DMD (Dynamic Mode Decomposition) method has attracted widespread attention as a representative modal-decomposition method and can build a predictive model. However, the DMD may give predicted results that deviate from physical reality…

Computational Physics · Physics 2023-11-29 Yuhui Yin , Chenhui Kou , Shengkun Jia , Lu Lu , Xigang Yuan , Yiqing Luo

Simulation of reasonable timescales for any long physical process using molecular dynamics (MD) is a major challenge in computational physics. In this study, we have implemented an approach based on multi-fidelity physics informed neural…

Computational Physics · Physics 2020-12-08 Mahmudul Islam , Md Shajedul Hoque Thakur , Satyajit Mojumder , Mohammad Nasim Hasan

Computer simulation is an important tool for scientific progress, especially when lab experiments are either extremely costly and difficult or lack the required resolution. However, all of the simulation methods come with limitations. In…

Fluid Dynamics · Physics 2023-08-04 Edward R. Smith , Panagiotis E. Theodorakis

Molecular dynamics (MD) simulations and computer-aided drug design (CADD) have advanced substantially over the past two decades, thanks to continuous computer hardware and software improvements. Given these advancements, MD simulations are…

Quantitative Methods · Quantitative Biology 2023-11-29 Mayar Ahmed , Alex M. Maldonado , Jacob D. Durrant
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