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Humans are routinely exposed to mixtures of chemical and other environmental factors, making the quantification of health effects associated with environmental mixtures a critical goal for establishing environmental policy sufficiently…

An important goal of environmental health research is to assess the risk posed by mixtures of environmental exposures. Two popular classes of models for mixtures analyses are response-surface methods and exposure-index methods.…

Methodology · Statistics 2025-05-01 Glen McGee , Ander Wilson , Thomas F. Webster , Brent A. Coull

The doubly robust estimator, which models both the propensity score and outcomes, is a popular approach to estimate the average treatment effect in the potential outcome setting. The primary appeal of this estimator is its theoretical…

Methodology · Statistics 2024-09-11 Kaoru Babasaki , Shonosuke Sugasawa , Kosaku Takanashi , Kenichiro McAlinn

Evaluating the causal health effects of multivariate, continuous exposures, such as air pollution mixtures, is a critical public health challenge. A primary obstacle is the frequent violation of the positivity assumption, which renders the…

Methodology · Statistics 2026-05-05 Zhuochao Huang , Kejin Dong , Tuo Lin , Joseph Antonelli

Estimating the joint effect of a multivariate, continuous exposure is crucial, particularly in environmental health where interest lies in simultaneously evaluating the impact of multiple environmental pollutants on health. We develop novel…

An important goal of environmental health research is to assess the health risks posed by mixtures of multiple environmental exposures. In these mixtures analyses, flexible models like Bayesian kernel machine regression and multiple index…

Methodology · Statistics 2025-12-29 Glen McGee , Joseph Antonelli

Studying the association between mixtures of environmental exposures and health outcomes can be challenging due to issues such as correlation among the exposures and non-linearities or interactions in the exposure-response function. For…

Applications · Statistics 2024-11-15 Jacob Englert , Stefanie Ebelt , Howard Chang

The analysis of environmental mixtures is of growing importance in environmental epidemiology, and one of the key goals in such analyses is to identify exposures and their interactions that are associated with adverse health outcomes.…

Methodology · Statistics 2021-03-22 Srijata Samanta , Joseph Antonelli

An important goal of environmental epidemiology is to quantify the complex health risks posed by a wide array of environmental exposures. In analyses focusing on a smaller number of exposures within a mixture, flexible models like Bayesian…

Methodology · Statistics 2024-09-27 Glen McGee , Brent A. Coull , Ander Wilson

A key goal of environmental health research is to assess the risk posed by mixtures of pollutants. As epidemiologic studies of mixtures can be expensive to conduct, it behooves researchers to incorporate prior knowledge about mixtures into…

Methodology · Statistics 2022-04-04 Glen McGee , Ander Wilson , Brent A Coull , Thomas F Webster

One of the major research questions regarding human microbiome studies is the feasibility of designing interventions that modulate the composition of the microbiome to promote health and cure disease. This requires extensive understanding…

Methodology · Statistics 2021-11-18 Matthew D. Koslovsky , Kristi L. Hoffman , Carrie R. Daniel , Marina Vannucci

Early detection of patients vulnerable to infections acquired in the hospital environment is a challenge in current health systems given the impact that such infections have on patient mortality and healthcare costs. This work is focused on…

Ensemble learning is a standard approach to building machine learning systems that capture complex phenomena in real-world data. An important aspect of these systems is the complete and valid quantification of model uncertainty. We…

Machine Learning · Computer Science 2019-11-12 Jeremiah Zhe Liu , John Paisley , Marianthi-Anna Kioumourtzoglou , Brent Coull

Several epidemiological studies have provided evidence that long-term exposure to fine particulate matter (PM2.5) increases mortality risk. Furthermore, some population characteristics (e.g., age, race, and socioeconomic status) might play…

Methodology · Statistics 2023-11-01 Dafne Zorzetto , Falco J. Bargagli-Stoffi , Antonio Canale , Francesca Dominici

In many medical and business applications, researchers are interested in estimating individualized treatment effects using data from a randomized experiment. For example in medical applications, doctors learn the treatment effects from…

Methodology · Statistics 2022-03-01 Kevin Wu Han , Han Wu

Distributed lag models are useful in environmental epidemiology as they allow the user to investigate critical windows of exposure, defined as the time period during which exposure to a pollutant adversely affects health outcomes. Recent…

Methodology · Statistics 2021-08-02 Joseph Antonelli , Ander Wilson , Brent Coull

This paper describes a method for a model-based analysis of clinical safety data called multivariate Bayesian logistic regression (MBLR). Parallel logistic regression models are fit to a set of medically related issues, or response…

Methodology · Statistics 2012-10-02 William DuMouchel

Environmental epidemiology has traditionally examined single exposure one at a time. Advances in exposure assessment and statistical methods now enable studies of multiple exposures and their combined health impacts. Bayesian Kernel Machine…

Methodology · Statistics 2026-02-02 Danlu Zhang , Stephanie M. Eick , Howard H. Chang

Statistical models often require inputs that are not completely known. This can occur when inputs are measured with error, indirectly, or when they are predicted using another model. In environmental epidemiology, air pollution exposure is…

Methodology · Statistics 2025-12-23 Konstantin Larin , Daniel R. Kowal

Microbiome research has immense potential for unlocking insights into human health and disease. A common goal in human microbiome research is identifying subgroups of individuals with similar microbial composition that may be linked to…

Methodology · Statistics 2025-08-21 Suppapat Korsurat , Matthew D. Koslovsky
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