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Recent advancements in large language models (LLMs) have demonstrated impressive performance in molecular generation, which offers potential to accelerate drug discovery. However, the current LLMs overlook a critical requirement for drug…

Machine Learning · Computer Science 2025-02-18 Hyosoon Jang , Yunhui Jang , Jaehyung Kim , Sungsoo Ahn

Recent advancements in artificial intelligence (AI), particularly in large language models (LLMs), have unlocked significant potential to enhance the quality and efficiency of medical care. By introducing a novel way to interact with AI and…

Retrosynthesis planning, essential in organic synthesis and drug discovery, has greatly benefited from recent AI-driven advancements. Nevertheless, existing methods frequently face limitations in both applicability and explainability.…

Computational Engineering, Finance, and Science · Computer Science 2025-07-24 Situo Zhang , Hanqi Li , Lu Chen , Zihan Zhao , Xuanze Lin , Zichen Zhu , Bo Chen , Xin Chen , Kai Yu

Large Language Models (LLMs) have enabled multi-agent systems to perform autonomous code generation for complex tasks. Despite the recent growth in research and industrial applications in this area, there is little work on synthesizing…

Software Engineering · Computer Science 2026-04-21 Zeeshan Rasheeda , Muhammad Waseema , Kai-Kristian Kemella , Mika Saari , Pekka Abrahamsson

Conventional biomedical research is increasingly labor-intensive due to the exponential growth of scientific literature and datasets. Artificial intelligence (AI), particularly Large Language Models (LLMs), has the potential to…

Multiagent Systems · Computer Science 2025-07-08 Yi Luo , Linghang Shi , Yihao Li , Aobo Zhuang , Yeyun Gong , Ling Liu , Chen Lin

Recent research has shown that large language models (LLMs) are particularly vulnerable to adversarial attacks. Since the release of ChatGPT, various industries are adopting LLM-based chatbots and virtual assistants in their data workflows.…

Cryptography and Security · Computer Science 2024-12-11 Ivan A. Fernandez , Subash Neupane , Sudip Mittal , Shahram Rahimi

Large language models (LLMs) integrated with autonomous agents hold significant potential for advancing scientific discovery through automated reasoning and task execution. However, applying LLM agents to drug discovery is still constrained…

Artificial Intelligence · Computer Science 2025-07-29 Kun Li , Zhennan Wu , Shoupeng Wang , Jia Wu , Shirui Pan , Wenbin Hu

The widespread of generative artificial intelligence has heightened concerns about the potential harms posed by AI-generated texts, primarily stemming from factoid, unfair, and toxic content. Previous researchers have invested much effort…

Computation and Language · Computer Science 2024-12-24 Shiyao Cui , Zhenyu Zhang , Yilong Chen , Wenyuan Zhang , Tianyun Liu , Siqi Wang , Tingwen Liu

In recent years, large language models (LLMs) have achieved state-of-the-art results in various biological sequence analysis tasks, such as sequence classification, structure prediction, and function prediction. Similar to advancements in…

Genomics · Quantitative Biology 2025-02-19 Wang Liang

The advancement and extensive application of large language models (LLMs) have been remarkable, including their use in scientific research assistance. However, these models often generate scientifically incorrect or unsafe responses, and in…

Computation and Language · Computer Science 2024-11-28 Haochen Zhao , Xiangru Tang , Ziran Yang , Xiao Han , Xuanzhi Feng , Yueqing Fan , Senhao Cheng , Di Jin , Yilun Zhao , Arman Cohan , Mark Gerstein

Large language models (LLMs) are becoming a popular tool as they have significantly advanced in their capability to tackle a wide range of language-based tasks. However, LLMs applications are highly vulnerable to prompt injection attacks,…

Computation and Language · Computer Science 2024-11-11 Md Abdur Rahman , Fan Wu , Alfredo Cuzzocrea , Sheikh Iqbal Ahamed

Research on the safety evaluation of large language models (LLMs) has become extensive, driven by jailbreak studies that elicit unsafe responses. Such response involves information already available to humans, such as the answer to "how to…

Cryptography and Security · Computer Science 2025-12-23 Yu Cui , Yifei Liu , Hang Fu , Sicheng Pan , Haibin Zhang , Cong Zuo , Licheng Wang

Large Language Models (LLMs) are increasingly deployed as agentic systems that plan, memorize, and act in open-world environments. This shift brings new security problems: failures are no longer only unsafe text generation, but can become…

Cryptography and Security · Computer Science 2026-03-03 Zhihang Deng , Jiaping Gui , Weinan Zhang

Several recent works have argued that Large Language Models (LLMs) can be used to tame the data deluge in the cybersecurity field, by improving the automation of Cyber Threat Intelligence (CTI) tasks. This work presents an evaluation…

Cryptography and Security · Computer Science 2025-11-13 Emanuele Mezzi , Fabio Massacci , Katja Tuma

Large Language Models (LLMs) have rapidly evolved over the past few years and are currently evaluated for their efficacy within the domain of offensive cyber-security. While initial forays showcase the potential of LLMs to enhance security…

Cryptography and Security · Computer Science 2025-06-11 Andreas Happe , Jürgen Cito

Large language models (LLMs) have revolutionized the field of artificial intelligence, endowing it with sophisticated language understanding and generation capabilities. However, when faced with more complex and interconnected tasks that…

Artificial Intelligence · Computer Science 2023-10-06 Thorsten Händler

Advances in large language models (LLMs) have recently opened new and promising avenues for small-molecule drug discovery. Yet existing LLM-based approaches for molecular generation often suffer from high rates of invalid and low-quality…

Machine Learning · Computer Science 2026-05-15 Andrew Y. Zhou , Sharvaree Vadgama , Sumanth Varambally , Peter Eckmann , Michael K. Gilson , Rose Yu

Agentic AI has been a topic of great interest recently. A Large Language Model (LLM) agent involves one or more LLMs in the back-end. In the front end, it conducts autonomous decision-making by combining the LLM outputs with results…

Artificial Intelligence · Computer Science 2026-03-19 Yuntong Zhang , Sungmin Kang , Ruijie Meng , Marcel Böhme , Abhik Roychoudhury

Significant scientific discoveries have driven the progress of human civilisation. The explosion of scientific literature and data has created information barriers across disciplines that have slowed the pace of scientific discovery. Large…

Computation and Language · Computer Science 2023-11-13 Biqing Qi , Kaiyan Zhang , Haoxiang Li , Kai Tian , Sihang Zeng , Zhang-Ren Chen , Bowen Zhou
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