Related papers: High-Throughput Mechanical Characterization of Gia…
Real-time deformability cytometry (RT-DC) is an established method that quantifies features like size, shape, and stiffness for whole cell populations on a single-cell level in real time. To extract the cell stiffness, a lookup table (LUT)…
A technique for determining the permeability of a phospholipid membrane on a single giant unilamellar vesicle (GUV) is described, which complements the existing methods utilizing either a planar black lipid membrane or sub-micrometre-sized…
This work attempts to understand the mechanism of simultaneous electrodeformation and electroporation in Giant Unilamellar Vesicles (GUVs) using a minimal analytical model. In the small deformation limit, the coupled electroporation,…
The deformability of vesicles critically influences their engulfment by lipid membranes, a process central to endocytosis, viral entry, drug delivery, and intercellular transport. While theoretical models have long predicted this influence,…
The way living tissues respond to external mechanical forces is crucial in physiological processes like embryogenesis, homeostasis or tumor growth. Providing a complete description across length scales which relates the properties of…
As described in the work of Mietke et al. (1) the deformation (defined as 1 - circularity [see (2)]) of a purely elastic, spherical object deformed in a real-time deformability cytometry (RT-DC) experiment can be mapped to its apparent…
Ultrasound-guided drug and gene delivery (usdg) enables controlled and spatially precise delivery of drugs and macromolecules, encapsulated in microbubbles (embs) and submicron gas vesicles (gvs), to target areas such as cancer tumors. It…
The low elastic modulus of soft materials, combined with geometric nonlinearity and rate dependence, presents significant challenges in the characterization of their mechanical response. We introduce a novel method for measuring the…
General-purpose Large Vision-Language Models (LVLMs), despite their massive scale, often falter in dermatology due to "diffuse attention" - the inability to disentangle subtle pathological lesions from background noise. In this paper, we…
We investigated the thermodynamic relaxation of giant unilamellar vesicles (GUVs) which contained small vesicles within their interior. Quenching these vesicles from their fluid phase (T>Tm) through the phase transition in the gel state…
A method for determining permeability of phospholipid bilayer based on the osmotic swelling of micrometer-sized giant unilamellar vesicles (GUVs) is presented as an alternative to the two established techniques, dynamic light scattering on…
Minimally invasive experimental methods that can measure local rate dependent mechanical properties are essential in understanding the behaviour of soft and biological materials in a wide range of applications. Needle based measurement…
X-ray computed tomography (XCT) has become a reliable metrology tool for measuring internal flaws and other microstructural features in engineering materials. However, tracking of material points to measure three-dimensional (3D)…
Tissue mechanics--stiffness, density and impedance contrast--are broadly informative biomarkers across diseases, yet routine CT, MRI, and B-mode ultrasound rarely quantify them directly. While ultrasound tomography (UT) is intrinsically…
This study introduces a systematic and optimised methodology for designing Linear Variable Differential Transformer (LVDT) sensors and Voice Coil (VC) actuators, tailored for high-precision applications such as gravitational wave detectors…
Endocytosis is a key cellular process involved in the uptake of nutrients, pathogens or the diagnosis and therapy of diseases. Most studies have focused on spherical objects, whereas biologically relevant shapes can be highly anisotropic.…
Identifying, measuring and reporting lesions accurately and comprehensively from patient CT scans are important yet time-consuming procedures for physicians. Computer-aided lesion/significant-findings detection techniques are at the core of…
The liquid-based detectors are widely used in particle and nuclear physics experiments. Due to the fixed way of constructing geometry in detector simulation such as Geant4, it is usually difficult to describe the non-uniformity of liquid in…
Vesicoureteral reflux (VUR) is traditionally assessed using subjective grading systems, which introduces variability in diagnosis. This study investigates the use of machine learning to improve diagnostic consistency by analyzing voiding…
The rheological characterisation of complex fluids is mostly performed under simple shear flow in rotational rheometers. Their modern commercial versions are extremely sensitive instruments which are able to provide very accurate…