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In many practical applications of multiple hypothesis testing using the False Discovery Rate (FDR), the given hypotheses can be naturally partitioned into groups, and one may not only want to control the number of false discoveries (wrongly…

Methodology · Statistics 2016-11-01 Rina Foygel Barber , Aaditya Ramdas

We consider the problem of identifying whether findings replicate from one study of high dimension to another, when the primary study guides the selection of hypotheses to be examined in the follow-up study as well as when there is no…

Methodology · Statistics 2014-01-28 Marina Bogomolov , Ruth Heller

The genetic basis of multiple phenotypes such as gene expression, metabolite levels, or imaging features is often investigated by testing a large collection of hypotheses, probing the existence of association between each of the traits and…

Applications · Statistics 2015-04-06 Christine Peterson , Marina Bogomolov , Yoav Benjamini , Chiara Sabatti

We introduce a joint posterior $p$-value, an extension of the posterior predictive $p$-value for multiple test statistics, designed to address limitations of existing Bayesian $p$-values in the setting of continuous model expansion. In…

Methodology · Statistics 2023-12-13 Collin Cademartori

Large language models (LLMs) achieve higher accuracy on challenging reasoning tasks by scaling test-time compute through multiple trajectory sampling. However, standard aggregation methods like majority voting or individual confidence-based…

Machine Learning · Computer Science 2026-02-04 Yingchuan Zhang , Terry Ma , Wenxuan Zhong , Ping Ma

Decision making or scientific discovery pipelines such as job hiring and drug discovery often involve multiple stages: before any resource-intensive step, there is often an initial screening that uses predictions from a machine learning…

Methodology · Statistics 2023-05-30 Ying Jin , Emmanuel J. Candès

Increased availability of data and accessibility of computational tools in recent years have created unprecedented opportunities for scientific research driven by statistical analysis. Inherent limitations of statistics impose constrains on…

Genomics · Quantitative Biology 2016-09-13 Olga A. Vsevolozhskaya , Gabriel Ruiz , Dmitri V. Zaykin

Assessment of replicability is critical to ensure the quality and rigor of scientific research. In this paper, we discuss inference and modeling principles for replicability assessment. Targeting distinct application scenarios, we propose…

Methodology · Statistics 2021-05-11 Yi Zhao , Xiaoquan Wen

We investigate the multiplicity model with m values of some test statistic independently drawn from a mixture of no effect (null) and positive effect (alternative), where we seek to identify, the alternative test results with a controlled…

Methodology · Statistics 2024-02-06 Zhiwen Jiang , Stephan Morgenthaler

Researchers often have datasets measuring features $x_{ij}$ of samples, such as test scores of students. In factor analysis and PCA, these features are thought to be influenced by unobserved factors, such as skills. Can we determine how…

Statistics Theory · Mathematics 2019-09-16 Edgar Dobriban

Objective: In this study, we aim to replicate an artefact-based study on software testing to address the gap. We focus on (a) providing a step by step guide of the replication, reflecting on challenges when replicating artefact-based…

Software Engineering · Computer Science 2022-04-14 Nasir Mehmood Minhas , Mohsin Irshad , Kai Petersen , Jürgen Börstler

Reproducibility is an important feature of science; experiments are retested, and analyses are repeated. Trust in the findings increases when consistent results are achieved. Despite the importance of reproducibility, significant work is…

Digital Libraries · Computer Science 2023-01-12 Akhil Pandey Akella , Hamed Alhoori , David Koop

The field of deep learning has witnessed significant breakthroughs, spanning various applications, and fundamentally transforming current software capabilities. However, alongside these advancements, there have been increasing concerns…

Machine Learning · Computer Science 2025-05-07 Nikita Ravi , Abhinav Goel , James C. Davis , George K. Thiruvathukal

In the field of multiple hypothesis testing, combining p-values represents a fundamental statistical method. The Cauchy combination test (CCT) (Liu and Xie, 2020) excels among numerous methods for combining p-values with powerful and…

Methodology · Statistics 2024-10-17 Yanyan Ouyang , Xingwei Liu , Lixing Zhu , Wangli Xu

$P$-values that are derived from continuously distributed test statistics are typically uniformly distributed on $(0,1)$ under least favorable parameter configurations (LFCs) in the null hypothesis. Conservativeness of a $p$-value $P$…

Methodology · Statistics 2023-03-13 Daniel Ochieng , Anh-Tuan Hoang , Thorsten Dickhaus

The two-trials rule in drug regulation requires statistically significant results from two pivotal trials to demonstrate efficacy. However, it is unclear how the effect estimates from both trials should be combined to quantify the drug…

Methodology · Statistics 2025-07-08 Samuel Pawel , Małgorzata Roos , Leonhard Held

Empirical science needs to be based on facts and claims that can be reproduced. This calls for replicating the studies that proclaim the claims, but practice in most fields still fails to implement this idea. When such studies emerged in…

Other Statistics · Statistics 2025-08-27 Werner A. Stahel

In partial label learning (PLL), each instance is associated with a set of candidate labels among which only one is ground-truth. The majority of the existing works focuses on constructing robust classifiers to estimate the labeling…

Machine Learning · Computer Science 2024-03-29 Chongjie Si , Xuehui Wang , Yan Wang , Xiaokang Yang , Wei Shen

To estimate casual treatment effects, we propose a new matching approach based on the reduced covariates obtained from sufficient dimension reduction. Compared to the original covariates and the propensity score, which are commonly used for…

Methodology · Statistics 2017-02-03 Wei Luo , Yeying Zhu

Subjective image quality assessment studies are used in many scenarios, such as the evaluation of compression, super-resolution, and denoising solutions. Among the available subjective test methodologies, pair comparison is attracting…

Multimedia · Computer Science 2024-03-19 Shima Mohammadi , João Ascenso