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Large language models are making autonomous drug discovery agents increasingly feasible, but reliable success in this setting is not determined by any single action or molecule. It is determined by whether the final returned set jointly…

Artificial Intelligence · Computer Science 2026-04-13 Maochen Sun , Youzhi Zhang , Gaofeng Meng

Individualized cognitive simulation (ICS) aims to build computational models that approximate the thought processes of specific individuals. While large language models (LLMs) convincingly mimic surface-level human behavior such as…

Artificial Intelligence · Computer Science 2025-10-24 Tianyi Zhang , Xiaolin Zhou , Yunzhe Wang , Erik Cambria , David Traum , Rui Mao

Large language model (LLM) agents extend generative models with reasoning, tool use, and persistent memory, thereby enabling the automation of complex tasks. In healthcare, such systems could support documentation, care coordination, and…

Artificial Intelligence · Computer Science 2026-03-24 Wenxian Yang , Hanzheng Qiu , Bangqun Zhang , Chengquan Li , Zhiyong Huang , Xiaobin Feng , Rongshan Yu , Jiahong Dong

Large Language Models (LLMs) have become essential in a variety of applications due to their advanced language understanding and generation capabilities. However, their computational and memory requirements pose significant challenges to…

Hardware Architecture · Computer Science 2024-12-02 Cristobal Ortega , Yann Falevoz , Renaud Ayrignac

Long-horizon LLM agents rely on persistent memory to support interactions across sessions, yet existing memory systems often retrieve context using semantic similarity or broad history inclusion, treating retrieved memories as uniformly…

Artificial Intelligence · Computer Science 2026-05-19 Saksham Sahai Srivastava

Large language models (LLMs) are rapidly transforming knowledge work by improving the quality and efficiency of tasks such as writing, coding, and data analysis. However, their growing use in education has exposed a learning-performance…

Recent advancements in Large Language Models (LLMs) have improved their ability to process extended conversational contexts, yet fine-tuning and evaluating short- and long-term memories remain difficult due to the absence of datasets that…

Computation and Language · Computer Science 2026-04-15 Manoj Madushanka Perera , Adnan Mahmood , Kasun Eranda Wijethilake , Quan Z. Sheng

LLM-based agents have been extensively applied across various domains, where memory stands out as one of their most essential capabilities. Previous memory mechanisms of LLM-based agents are manually predefined by human experts, leading to…

Machine Learning · Computer Science 2025-08-26 Zeyu Zhang , Quanyu Dai , Rui Li , Xiaohe Bo , Xu Chen , Zhenhua Dong

Human interaction with the external world fundamentally involves the exchange of personal memory, whether with other individuals, websites, applications, or, in the future, AI agents. A significant portion of this interaction is redundant,…

Artificial Intelligence · Computer Science 2025-03-13 Jiale Wei , Xiang Ying , Tao Gao , Fangyi Bao , Felix Tao , Jingbo Shang

Large Language Models (LLMs) are often evaluated against ideals of perfect Bayesian inference, yet growing evidence suggests that their in-context reasoning exhibits systematic forgetting of past information. Rather than viewing this…

Computation and Language · Computer Science 2026-04-08 Alexandros Christoforos

This comprehensive review explores the intersection of Large Language Models (LLMs) and cognitive science, examining similarities and differences between LLMs and human cognitive processes. We analyze methods for evaluating LLMs cognitive…

With the success of large language models (LLMs), integrating the vision model into LLMs to build vision-language foundation models has gained much more interest recently. However, existing LLM-based large multimodal models (e.g.,…

Computer Vision and Pattern Recognition · Computer Science 2024-04-25 Bo He , Hengduo Li , Young Kyun Jang , Menglin Jia , Xuefei Cao , Ashish Shah , Abhinav Shrivastava , Ser-Nam Lim

LLM-based conversational AI agents struggle to maintain coherent behavior over long horizons due to limited context. While RAG-based approaches are increasingly adopted to overcome this limitation by storing interactions in external memory…

Artificial Intelligence · Computer Science 2026-05-13 Jiazhou Liang , Armin Toroghi , Yifan Simon Liu , Faeze Moradi Kalarde , Liam Gallagher , Scott Sanner

Large language models (LLMs) struggle with maintaining coherence in extended conversations spanning hundreds of turns, despite performing well within their context windows. This paper introduces HEMA (Hippocampus-Inspired Extended Memory…

Computation and Language · Computer Science 2025-04-24 Kwangseob Ahn

Recent efforts have augmented large language models (LLMs) with external resources (e.g., the Internet) or internal control flows (e.g., prompt chaining) for tasks requiring grounding or reasoning, leading to a new class of language agents.…

Artificial Intelligence · Computer Science 2024-03-18 Theodore R. Sumers , Shunyu Yao , Karthik Narasimhan , Thomas L. Griffiths

We present SCM (Sleep-Consolidated Memory), a research preview of a memory architecture for large language models that draws on neuroscientific principles to address a fundamental limitation in current systems: the absence of persistent,…

Machine Learning · Computer Science 2026-04-24 Saish Sachin Shinde

Agentic code generation requires large language models (LLMs) capable of complex context management and multi-step reasoning. Prior multi-agent frameworks attempt to address these challenges through collaboration, yet they often suffer from…

Software Engineering · Computer Science 2026-01-13 Ming-Tung Shen , Yuh-Jzer Joung

Large language models (LLMs) have shown remarkable capabilities, but still struggle with processing extensive contexts, limiting their ability to maintain coherence and accuracy over long sequences. In contrast, the human brain excels at…

Long-term conversational large language model (LLM) agents require memory systems that can recover relevant evidence from historical interactions without overwhelming the answer stage with irrelevant context. However, existing memory…

Computation and Language · Computer Science 2026-04-23 Shuqi Cao , Jingyi He , Fei Tan

The development of sophisticated artificial intelligence (AI) conversational agents based on large language models raises important questions about the relationship between human norms, values, and practices and AI design and performance.…

Computers and Society · Computer Science 2025-05-30 Rachel Katharine Sterken , James Ravi Kirkpatrick