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Multi-instance learning attempts to learn from a training set consisting of labeled bags each containing many unlabeled instances. Previous studies typically treat the instances in the bags as independently and identically distributed.…

Machine Learning · Computer Science 2009-05-13 Zhi-Hua Zhou , Yu-Yin Sun , Yu-Feng Li

Incremental learning targets at achieving good performance on new categories without forgetting old ones. Knowledge distillation has been shown critical in preserving the performance on old classes. Conventional methods, however,…

Computer Vision and Pattern Recognition · Computer Science 2020-09-08 Peng Zhou , Long Mai , Jianming Zhang , Ning Xu , Zuxuan Wu , Larry S. Davis

Whole slide image (WSI) assessment is a challenging and crucial step in cancer diagnosis and treatment planning. WSIs require high magnifications to facilitate sub-cellular analysis. Precise annotations for patch- or even pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2023-11-20 Simon Holdenried-Krafft , Peter Somers , Ivonne A. Montes-Majarro , Diana Silimon , Cristina Tarín , Falko Fend , Hendrik P. A. Lensch

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Linhao Qu , Dingkang Yang , Dan Huang , Qinhao Guo , Rongkui Luo , Shaoting Zhang , Xiaosong Wang

Weakly supervised whole slide image (WSI) classification is challenging due to the lack of patch-level labels and high computational costs. State-of-the-art methods use self-supervised patch-wise feature representations for multiple…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Wentao Huang , Xiaoling Hu , Shahira Abousamra , Prateek Prasanna , Chao Chen

Multi-label image classification is a fundamental but challenging task towards general visual understanding. Existing methods found the region-level cues (e.g., features from RoIs) can facilitate multi-label classification. Nevertheless,…

Computer Vision and Pattern Recognition · Computer Science 2019-02-22 Yongcheng Liu , Lu Sheng , Jing Shao , Junjie Yan , Shiming Xiang , Chunhong Pan

We apply deep learning (DL) on Magnetic resonance spectroscopy (MRS) data for the task of brain tumor detection. Medical applications often suffer from data scarcity and corruption by noise. Both of these problems are prominent in our data…

Machine Learning · Computer Science 2021-12-17 Diyuan Lu , Gerhard Kurz , Nenad Polomac , Iskra Gacheva , Elke Hattingen , Jochen Triesch

In many histopathology tasks, sample classification depends on morphological details in tissue or single cells that are only visible at the highest magnification. For a pathologist, this implies tedious zooming in and out, while for a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Ario Sadafi , Nassir Navab , Carsten Marr

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Deep Learning has emerged as a promising approach for skin lesion analysis. However, existing methods mostly rely on fully supervised learning, requiring extensive labeled data, which is challenging and costly to obtain. To alleviate this…

Image and Video Processing · Electrical Eng. & Systems 2025-08-18 Siyamalan Manivannan

Whole Slide Image (WSI) analysis is a powerful method to facilitate the diagnosis of cancer in tissue samples. Automating this diagnosis poses various issues, most notably caused by the immense image resolution and limited annotations. WSIs…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Ahmet Gokberk Gul , Oezdemir Cetin , Christoph Reich , Tim Prangemeier , Nadine Flinner , Heinz Koeppl

Semi-supervised instance segmentation poses challenges due to limited labeled data, causing difficulties in accurately localizing distinct object instances. Current teacher-student frameworks still suffer from performance constraints due to…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Heeji Yoon , Heeseong Shin , Eunbeen Hong , Hyunwook Choi , Hansang Cho , Daun Jeong , Seungryong Kim

Recent advancements in computational pathology and artificial intelligence have significantly improved whole slide image (WSI) classification. However, the gigapixel resolution of WSIs and the scarcity of manual annotations present…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Mingxi Ouyang , Yuqiu Fu , Renao Yan , ShanShan Shi , Xitong Ling , Lianghui Zhu , Yonghong He , Tian Guan

Hispathological image segmentation algorithms play a critical role in computer aided diagnosis technology. The development of weakly supervised segmentation algorithm alleviates the problem of medical image annotation that it is…

Computer Vision and Pattern Recognition · Computer Science 2022-05-19 Ziniu Qian , Kailu Li , Maode Lai , Eric I-Chao Chang , Bingzheng Wei , Yubo Fan , Yan Xu

Multiple Instance Learning (MIL), a powerful strategy for weakly supervised learning, is able to perform various prediction tasks on gigapixel Whole Slide Images (WSIs). However, the tens of thousands of patches in WSIs usually incur a vast…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Zhuchen Shao , Liuxi Dai , Yifeng Wang , Haoqian Wang , Yongbing Zhang

Although instance segmentation methods have improved considerably, the dominant paradigm is to rely on fully-annotated training images, which are tedious to obtain. To alleviate this reliance, and boost results, semi-supervised approaches…

Computer Vision and Pattern Recognition · Computer Science 2023-12-15 Tariq Berrada , Camille Couprie , Karteek Alahari , Jakob Verbeek

Labeling data for classification requires significant human effort. To reduce labeling cost, instead of labeling every instance, a group of instances (bag) is labeled by a single bag label. Computer algorithms are then used to infer the…

Machine Learning · Statistics 2014-11-18 Anh T. Pham , Raviv Raich , Xiaoli Z. Fern

Whole-slide image (WSI) classification in computational pathology is commonly formulated as slide-level Multiple Instance Learning (MIL) with a single global bag representation. However, slide-level MIL is fundamentally underconstrained:…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Syed Fahim Ahmed , Gnanesh Rasineni , Florian Koehler , Abu Zahid Bin Aziz , Mei Wang , Attila Gyulassy , Brian Summa , J. Quincy Brown , Valerio Pascucci , Shireen Y. Elhabian

For classifying digital whole slide images in the absence of pixel level annotation, typically multiple instance learning methods are applied. Due to the generic applicability, such methods are currently of very high interest in the…

Multiple instance learning exhibits a powerful approach for whole slide image-based diagnosis in the absence of pixel- or patch-level annotations. In spite of the huge size of hole slide images, the number of individual slides is often…