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Generative models trained on internet-scale data are capable of generating novel and realistic texts, images, and videos. A natural next question is whether these models can advance science, for example by generating novel stable materials.…

Machine Learning · Computer Science 2024-06-05 Sherry Yang , KwangHwan Cho , Amil Merchant , Pieter Abbeel , Dale Schuurmans , Igor Mordatch , Ekin Dogus Cubuk

Predicting molecular conformations from molecular graphs is a fundamental problem in cheminformatics and drug discovery. Recently, significant progress has been achieved with machine learning approaches, especially with deep generative…

Machine Learning · Computer Science 2022-03-16 Minkai Xu , Lantao Yu , Yang Song , Chence Shi , Stefano Ermon , Jian Tang

Conventional galaxy generation methods rely on semi-analytical models and hydrodynamic simulations, which are highly dependent on physical assumptions and parameter tuning. In contrast, data-driven generative models do not have explicit…

Instrumentation and Methods for Astrophysics · Physics 2026-04-06 Xingzhong Fan , Hongming Tang , Yue Zeng , M. B. N. Kouwenhoven , Guangquan Zeng

We consider the prediction of general tensor properties of crystalline materials, including dielectric, piezoelectric, and elastic tensors. A key challenge here is how to make the predictions satisfy the unique tensor equivariance to O(3)…

Materials Science · Physics 2024-06-21 Keqiang Yan , Alexandra Saxton , Xiaofeng Qian , Xiaoning Qian , Shuiwang Ji

In recent years, the realm of crystalline materials has witnessed a surge in the development of generative models, predominantly aimed at the inverse design of crystals with tailored physical properties. However, spatial symmetry, which…

Computational Physics · Physics 2024-10-31 Baoning Wang , Zhiyuan Xu , Zhiyu Han , Qiwen Nie , Hang Xiao , Gang Yan

We formulate topological crystalline materials on the basis of the twisted equivariant $K$-theory. Basic ideas of the twisted equivariant $K$-theory is explained with application to topological phases protected by crystalline symmetries in…

Mesoscale and Nanoscale Physics · Physics 2017-06-28 Ken Shiozaki , Masatoshi Sato , Kiyonori Gomi

Crystal structure prediction (CSP), which aims to predict the three-dimensional atomic arrangement of a crystal from its composition, is central to materials discovery and mechanistic understanding. However, given the composition in a unit…

Materials Science · Physics 2026-03-10 Shi Yin , Jinming Mu , Xudong Zhu , Linxin He

Generative models have shown great promise in generating 3D geometric systems, which is a fundamental problem in many natural science domains such as molecule and protein design. However, existing approaches only operate on static…

Computer Vision and Pattern Recognition · Computer Science 2024-10-18 Jiaqi Han , Minkai Xu , Aaron Lou , Haotian Ye , Stefano Ermon

Exploring the vast composition space of multi-component alloys presents a challenging task for both \textit{ab initio} (first principles) and experimental methods due to the time-consuming procedures involved. This ultimately impedes the…

Generating the periodic structure of stable materials is a long-standing challenge for the material design community. This task is difficult because stable materials only exist in a low-dimensional subspace of all possible periodic…

Machine Learning · Computer Science 2022-03-15 Tian Xie , Xiang Fu , Octavian-Eugen Ganea , Regina Barzilay , Tommi Jaakkola

Efficient algorithms to generate candidate crystal structures with good stability properties can play a key role in data-driven materials discovery. Here we show that a crystal diffusion variational autoencoder (CDVAE) is capable of…

Materials Science · Physics 2022-11-18 Peder Lyngby , Kristian Sommer Thygesen

A peculiar feature of quantum states is that they may embody so-called projective representations of symmetries rather than ordinary representations. Projective representations of space groups-the defining symmetry of crystals-remain…

Mesoscale and Nanoscale Physics · Physics 2023-02-14 Z. Y. Chen , Zheng Zhang , Shengyuan A. Yang , Y. X. Zhao

The discovery of inorganic crystal structures with targeted properties is a significant challenge in materials science. Generative models, especially state-of-the-art diffusion models, offer the promise of modeling complex data…

This work introduces a diffusion model for molecule generation in 3D that is equivariant to Euclidean transformations. Our E(3) Equivariant Diffusion Model (EDM) learns to denoise a diffusion process with an equivariant network that jointly…

Machine Learning · Computer Science 2022-06-17 Emiel Hoogeboom , Victor Garcia Satorras , Clément Vignac , Max Welling

In recent years, diffusion-based models have demonstrated exceptional performance in searching for simultaneously stable, unique, and novel (S.U.N.) crystalline materials. However, most of these models don't have the ability to change the…

Machine Learning · Computer Science 2026-05-29 Andrey Okhotin , Maksim Nakhodnov , Nikita Kazeev , Mikhail Lazarev , Andrey E Ustyuzhanin , Dmitry Vetrov

Generating images from graph-structured inputs, such as scene graphs, is uniquely challenging due to the difficulty of aligning nodes and connections in graphs with objects and their relations in images. Most existing methods address this…

Computer Vision and Pattern Recognition · Computer Science 2022-11-22 Ling Yang , Zhilin Huang , Yang Song , Shenda Hong , Guohao Li , Wentao Zhang , Bin Cui , Bernard Ghanem , Ming-Hsuan Yang

Inverse design of solid-state materials with desired properties represents a formidable challenge in materials science. Although recent generative models have demonstrated potential, their adoption has been hindered by limitations such as…

Materials Science · Physics 2024-08-15 Yan Chen , Xueru Wang , Xiaobin Deng , Yilun Liu , Xi Chen , Yunwei Zhang , Lei Wang , Hang Xiao

Graph-structured data jointly contain discrete topology and continuous geometry, which poses fundamental challenges for generative modeling due to heterogeneous distributions, incompatible noise dynamics, and the need for equivariant…

Machine Learning · Computer Science 2026-04-10 Rongjian Xu , Teng Pang , Zhiqiang Dong , Guoqiang Wu

Symmetry groups are projectively represented in quantum mechanics, and crystalline symmetries are fundamental in condensed matter physics. Here, we systematically present a unified theory of quantum mechanical space groups from two…

Mathematical Physics · Physics 2020-09-17 Y. X. Zhao , L. B. Shao

Crystal structures are characterized by atomic bases within a primitive unit cell that repeats along a regular lattice throughout 3D space. The periodic and infinite nature of crystals poses unique challenges for geometric graph…

Machine Learning · Computer Science 2024-03-19 Keqiang Yan , Cong Fu , Xiaofeng Qian , Xiaoning Qian , Shuiwang Ji