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A patient undergoes multiple examinations in each hospital stay, where each provides different facets of the health status. These assessments include temporal data with varying sampling rates, discrete single-point measurements, therapeutic…

Computer Vision and Pattern Recognition · Computer Science 2025-01-31 Malte Tölle , Mohamad Scharaf , Samantha Fischer , Christoph Reich , Silav Zeid , Christoph Dieterich , Benjamin Meder , Norbert Frey , Philipp Wild , Sandy Engelhardt

It is possible to find the optimized radiation dose per session for a radiotherapy (RT) treatment, using a population dynamics model. This has already been done in a previous work for a protocol with 30 sessions and a fixed dose per…

Modern large language model (LLM) training is inherently dynamic: resource fluctuations, RLHF phase shifts, and cluster elasticity continually reshape the optimal parallelism layout, posing a significant challenge to existing training…

Machine Learning · Computer Science 2026-05-20 Yuanqing Wang , Yuchen Zhang , Hao Lin , Junhao Hu , Chunyang Zhu , Quanlu Zhang , Boxun Li , Guohao Dai , Zhi Yang , Daning Cheng , Yunquan Zhang , Yu Wang

Radiation therapy aims to deliver the prescribed amount of dose to a tumour at the same time as sparing the surrounding tissues as much as possible. In charged particle therapy, delivering the prescribed dose is equivalent to delivering the…

Medical Physics · Physics 2018-03-05 Simona Giordanengo , Marco Donetti

The use of neural networks to directly predict three-dimensional dose distributions for automatic planning is becoming popular. However, the existing methods only use patient anatomy as input and assume consistent beam configuration for all…

Recent advancements in vision-language systems have improved the accuracy of Radiological Visual Question Answering (VQA) Models. However, some challenges remain across each stage of model development: limited expert-labeled images hinders…

Computer Vision and Pattern Recognition · Computer Science 2025-06-18 Aditya Shourya , Michel Dumontier , Chang Sun

Machine learning methods are increasingly used to build computationally inexpensive surrogates for complex physical models. The predictive capability of these surrogates suffers when data are noisy, sparse, or time-dependent. As we are…

Machine Learning · Computer Science 2024-05-20 A. Diaw , M. McKerns , I. Sagert , L. G. Stanton , M. S. Murillo

Artificial intelligence (AI) is poised to transform healthcare by enabling personalized and efficient care through data-driven insights. Although radiology is at the forefront of AI adoption, in practice, the potential of AI models is often…

Computer Vision and Pattern Recognition · Computer Science 2025-02-17 Benjamin D. Killeen , Bohua Wan , Aditya V. Kulkarni , Nathan Drenkow , Michael Oberst , Paul H. Yi , Mathias Unberath

Radiotherapy inverse planning often requires planners to modify parameters in the treatment planning system's objective function to produce clinically acceptable plans. Due to the manual steps in this process, plan quality can vary…

Medical Physics · Physics 2022-05-11 Kelsey Maass , Aleksandr Aravkin , Minsun Kim

In the past decades mathematical optimization has found its way into radiation therapy and has made profound practice changing impact. Today, virtually all advanced treatment delivery methods, such as IMRT, VMAT, tomotherapy, LDR/HDR…

Medical Physics · Physics 2018-10-31 Bram L. Gorissen , Jan Unkelbach , Thomas R. Bortfeld

In recent years, volumetric modulated arc therapy (VMAT) has been becoming a more and more important radiation technique widely used in clinical application for cancer treatment. One of the key problems in VMAT is treatment plan…

Medical Physics · Physics 2016-01-06 Yu Yang , Bin Dong , Zaiwen Wen

How can we plan efficiently in a large and complex environment when the time budget is limited? Given the original simulator of the environment, which may be computationally very demanding, we propose to learn online an approximate but much…

Artificial Intelligence · Computer Science 2022-12-14 Jinke He , Miguel Suau , Hendrik Baier , Michael Kaisers , Frans A. Oliehoek

We present a method of directly optimizing on deviations in clinical goal values in radiation therapy treatment planning. Using a new mathematical framework in which metrics derived from the dose-volume histogram are regarded as functionals…

Medical Physics · Physics 2021-09-07 Tianfang Zhang , Rasmus Bokrantz , Jimmy Olsson

Model-based reinforcement learning methods often use learning only for the purpose of estimating an approximate dynamics model, offloading the rest of the decision-making work to classical trajectory optimizers. While conceptually simple,…

Machine Learning · Computer Science 2022-12-22 Michael Janner , Yilun Du , Joshua B. Tenenbaum , Sergey Levine

Radiotherapy is a crucial cancer treatment that demands precise planning to balance tumor eradication and preservation of healthy tissue. Traditional treatment planning (TP) is iterative, time-consuming, and reliant on human expertise,…

Machine Learning · Computer Science 2025-02-10 Matteo Ferrante , Alessandra Carosi , Rolando Maria D Angelillo , Nicola Toschi

Diffusion models have risen as a promising approach to data-driven planning, and have demonstrated impressive robotic control, reinforcement learning, and video planning performance. Given an effective planner, an important question to…

Robotics · Computer Science 2023-10-17 Siyuan Zhou , Yilun Du , Shun Zhang , Mengdi Xu , Yikang Shen , Wei Xiao , Dit-Yan Yeung , Chuang Gan

Radiopharmaceutical therapies are expanding rapidly, but clinical evidence generation is limited by operational constraints and biological heterogeneity in radiopharmaceutical delivery and radiation risk. Virtual theranostic trials can run…

Conventional radiotherapy dose calculation algorithms are often computationally slow and non-differentiable, creating bottlenecks for online adaptive radiotherapy (ART) and limiting end-to-end automatic planning. Deep learning provides…

Stochastic simulators are an indispensable tool in many branches of science. Often based on first principles, they deliver a series of samples whose distribution implicitly defines a probability measure to describe the phenomena of…

Data Analysis, Statistics and Probability · Physics 2022-01-19 Chris Pollard , Philipp Windischhofer

This research proposes and evaluates scoring and assessment methods for Virtual Reality (VR) training simulators. VR simulators capture detailed n-dimensional human motion data which is useful for performance analysis. Custom made medical…

Signal Processing · Electrical Eng. & Systems 2020-06-23 Neil Vaughan , Bogdan Gabrys