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With an increase in deep learning-based methods, the call for explainability of such methods grows, especially in high-stakes decision making areas such as medical image analysis. This survey presents an overview of eXplainable Artificial…

Image and Video Processing · Electrical Eng. & Systems 2022-05-06 Bas H. M. van der Velden , Hugo J. Kuijf , Kenneth G. A. Gilhuijs , Max A. Viergever

Explainable Artificial Intelligence (XAI) is essential for the transparency and clinical adoption of Clinical Decision Support Systems (CDSS). However, the real-world effectiveness of existing XAI methods remains limited and is…

Machine Learning · Computer Science 2026-01-26 Alessandro Gambetti , Qiwei Han , Hong Shen , Claudia Soares

Deep learning (DL) has substantially enhanced natural language processing (NLP) in healthcare research. However, the increasing complexity of DL-based NLP necessitates transparent model interpretability, or at least explainability, for…

Computation and Language · Computer Science 2024-10-17 Guangming Huang , Yingya Li , Shoaib Jameel , Yunfei Long , Giorgos Papanastasiou

Artificial Intelligence (AI) is rapidly embedded in critical decision-making systems, however their foundational ``black-box'' models require eXplainable AI (XAI) solutions to enhance transparency, which are mostly oriented to experts,…

Machine Learning · Computer Science 2025-06-17 Eva Paraschou , Ioannis Arapakis , Sofia Yfantidou , Sebastian Macaluso , Athena Vakali

The adoption of intelligent systems creates opportunities as well as challenges for medical work. On the positive side, intelligent systems have the potential to compute complex data from patients and generate automated diagnosis…

Human-Computer Interaction · Computer Science 2019-02-19 Yao Xie , Ge Gao , Xiang 'Anthony' Chen

Large Language Models (LLMs) offer a promising approach to enhancing Explainable AI (XAI) by transforming complex machine learning outputs into easy-to-understand narratives, making model predictions more accessible to users, and helping…

Artificial Intelligence · Computer Science 2025-04-02 Ahsan Bilal , David Ebert , Beiyu Lin

This review paper provides an integrated perspective of Explainable Artificial Intelligence techniques applied to Brain-Computer Interfaces. BCIs use predictive models to interpret brain signals for various high-stake applications. However,…

Human-Computer Interaction · Computer Science 2023-12-21 Param Rajpura , Hubert Cecotti , Yogesh Kumar Meena

Explainable Artificial Intelligence (XAI) has re-emerged in response to the development of modern AI and ML systems. These systems are complex and sometimes biased, but they nevertheless make decisions that impact our lives. XAI systems are…

Artificial Intelligence · Computer Science 2021-02-10 Shane T. Mueller , Elizabeth S. Veinott , Robert R. Hoffman , Gary Klein , Lamia Alam , Tauseef Mamun , William J. Clancey

XAI refers to the techniques and methods for building AI applications which assist end users to interpret output and predictions of AI models. Black box AI applications in high-stakes decision-making situations, such as medical domain have…

In explainable artificial intelligence (XAI) research, the predominant focus has been on interpreting models for experts and practitioners. Model agnostic and local explanation approaches are deemed interpretable and sufficient in many…

Artificial Intelligence · Computer Science 2024-02-01 Adarsa Sivaprasad , Ehud Reiter , Nava Tintarev , Nir Oren

In recent years, AI systems in the medical domain have advanced significantly. However, despite outperforming humans, they are rarely used in practice since it is often not clear how they make their decisions. Optimal explanation and…

Human-Computer Interaction · Computer Science 2026-05-06 Julia Wagner , Tim Schlippe

As large language models (LLMs) are increasingly deployed in sensitive domains such as healthcare, law, and education, the demand for transparent, interpretable, and accountable AI systems becomes more urgent. Explainable AI (XAI) acts as a…

Computers and Society · Computer Science 2025-05-28 Francisco Herrera

Explainable AI (XAI) aims to improve user understanding and decisions when using AI models. However, despite innovations in XAI, recent user evaluations reveal that this goal remains elusive. Understanding human cognition can help explain…

Artificial Intelligence · Computer Science 2026-05-01 Louth Bin Rawshan , Zhuoyu Wang , Brian Y. Lim

Chest X-ray imaging is crucial for diagnosing pulmonary and cardiac diseases, yet its interpretation demands extensive clinical experience and suffers from inter-observer variability. While deep learning models offer high diagnostic…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Chee Ng , Liliang Sun , Shaoqing Tang

Explainable Artificial Intelligence (XAI) is an emerging research field bringing transparency to highly complex and opaque machine learning (ML) models. Despite the development of a multitude of methods to explain the decisions of black-box…

Machine Learning · Computer Science 2022-03-16 Leander Weber , Sebastian Lapuschkin , Alexander Binder , Wojciech Samek

Large Language Models (LLMs) have played a pivotal role in advancing Artificial Intelligence (AI). However, despite their achievements, LLMs often struggle to explain their decision-making processes, making them a 'black box' and presenting…

Computation and Language · Computer Science 2025-06-30 Avash Palikhe , Zhenyu Yu , Zichong Wang , Wenbin Zhang

The field of Explainable Artificial Intelligence (XAI) often focuses on users with a strong technical background, making it challenging for non-experts to understand XAI methods. This paper presents "x-[plAIn]", a new approach to make XAI…

Lung and colon cancer are serious worldwide health challenges that require early and precise identification to reduce mortality risks. However, diagnosis, which is mostly dependent on histopathologists' competence, presents difficulties and…

Image and Video Processing · Electrical Eng. & Systems 2024-05-15 Mukaffi Bin Moin , Fatema Tuj Johora Faria , Swarnajit Saha , Busra Kamal Rafa , Mohammad Shafiul Alam

Model explainability is essential for the creation of trustworthy Machine Learning models in healthcare. An ideal explanation resembles the decision-making process of a domain expert and is expressed using concepts or terminology that is…

Machine Learning · Computer Science 2021-07-14 Sumedha Singla , Stephen Wallace , Sofia Triantafillou , Kayhan Batmanghelich

Explainable artificial intelligence (XAI) has become increasingly important in biomedical image analysis to promote transparency, trust, and clinical adoption of DL models. While several surveys have reviewed XAI techniques, they often lack…

Computer Vision and Pattern Recognition · Computer Science 2025-07-11 Getamesay Haile Dagnaw , Yanming Zhu , Muhammad Hassan Maqsood , Wencheng Yang , Xingshuai Dong , Xuefei Yin , Alan Wee-Chung Liew