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Related papers: A Comparative Review of RNA Language Models

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General-purpose language models are trained to produce varied natural language outputs, but for some tasks, like annotation or classification, we need more specific output formats. LLM systems increasingly support structured output, which…

Computation and Language · Computer Science 2025-08-04 Sil Hamilton , David Mimno

Recent advances in protein language models (PLMs) have demonstrated remarkable capabilities in understanding protein sequences. However, the extent to which different model architectures capture antibody-specific biological properties…

Machine Learning · Computer Science 2025-12-11 Mengren , Liu , Yixiang Zhang , Yiming , Zhang

In this study, we tackle the challenging task of predicting secondary structures from protein primary sequences, a pivotal initial stride towards predicting tertiary structures, while yielding crucial insights into protein activity,…

Machine Learning · Computer Science 2025-11-18 Disha Varshney , Samarth Garg , Sarthak Tyagi , Deeksha Varshney , Nayan Deep , Asif Ekbal

Large language models (LLMs) have shown strong ability in generating rich representations across domains such as natural language processing and generation, computer vision, and multimodal learning. However, their application in biomedical…

Genomics · Quantitative Biology 2025-09-30 Luxuan Zhang , Douglas Jiang , Qinglong Wang , Haoqi Sun , Feng Tian

Large language models (LLMs) are increasingly used to support the analysis of complex financial disclosures, yet their reliability, behavioral consistency, and transparency remain insufficiently understood in high-stakes settings. This…

Computation and Language · Computer Science 2026-01-21 Md Talha Mohsin

Several recent works seek to develop foundation models specifically for medical applications, adapting general-purpose large language models (LLMs) and vision-language models (VLMs) via continued pretraining on publicly available biomedical…

Computation and Language · Computer Science 2024-11-21 Daniel P. Jeong , Saurabh Garg , Zachary C. Lipton , Michael Oberst

Recently, Language Models (LMs) instruction-tuned on multiple tasks, also known as multitask-prompted fine-tuning (MT), have shown the capability to generalize to unseen tasks. Previous work has shown that scaling the number of training…

Computation and Language · Computer Science 2023-02-10 Joel Jang , Seungone Kim , Seonghyeon Ye , Doyoung Kim , Lajanugen Logeswaran , Moontae Lee , Kyungjae Lee , Minjoon Seo

Large Language Models revolutionized NLP and showed dramatic performance improvements across several tasks. In this paper, we investigated the role of such language models in text classification and how they compare with other approaches…

Computation and Language · Computer Science 2025-02-21 Sowmya Vajjala , Shwetali Shimangaud

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Large Language Models (LLMs) have emerged as dominant foundational models in modern NLP. However, the understanding of their prediction processes and internal mechanisms, such as feed-forward networks (FFN) and multi-head self-attention…

Computation and Language · Computer Science 2024-04-16 Xintong Wang , Xiaoyu Li , Xingshan Li , Chris Biemann

Proteins are essential macromolecules defined by their amino acid sequences, which determine their three-dimensional structures and, consequently, their functions in all living organisms. Therefore, generative protein modeling necessitates…

Machine Learning · Computer Science 2024-10-18 Xinyou Wang , Zaixiang Zheng , Fei Ye , Dongyu Xue , Shujian Huang , Quanquan Gu

Word vectors and Language Models (LMs) pretrained on a large amount of unlabelled data can dramatically improve various Natural Language Processing (NLP) tasks. However, the measure and impact of similarity between pretraining data and…

Computation and Language · Computer Science 2019-05-20 Xiang Dai , Sarvnaz Karimi , Ben Hachey , Cecile Paris

Motivation: Proteins are of great significance in living organisms. However, understanding their functions encounters numerous challenges, such as insufficient integration of multimodal information, a large number of training parameters,…

Machine Learning · Computer Science 2025-05-23 Zhicong Wang , Zicheng Ma , Ziqiang Cao , Changlong Zhou , Jun Zhang , Yiqin Gao

As the performance of Large-scale Vision Language Models (LVLMs) improves, they are increasingly capable of responding in multiple languages, and there is an expectation that the demand for explanations generated by LVLMs will grow.…

Computation and Language · Computer Science 2025-02-17 Shintaro Ozaki , Kazuki Hayashi , Yusuke Sakai , Hidetaka Kamigaito , Katsuhiko Hayashi , Taro Watanabe

A prior-informed large language model (LLM) driven multi-task learning framework is proposed for the unified description of multiple nuclear observables. By fine-tuning the pre-trained DeepSeek-R1-1.5B model with Low-Rank Adaptation (LoRA),…

Nuclear Theory · Physics 2026-05-29 S. J. Guo , S. Y. Wang , E. H. Wang , Z. M. Niu , Y. M. Ding

Targeting RNA with small molecules offers significant therapeutic potential. Machine learning could substantially accelerate preclinical drug discovery, from hit identification to lead optimization. Yet a fundamental limitation emerges:…

Biomolecules · Quantitative Biology 2025-12-18 Wissam Karroucha , Carlos Oliver , Veronique Stoven , Vincent Mallet

Large Language Models (LLMs) need to be aligned with human expectations to ensure their safety and utility in most applications. Alignment is challenging, costly, and needs to be repeated for every LLM and alignment criterion. We propose to…

Computation and Language · Computer Science 2024-10-07 Lilian Ngweta , Mayank Agarwal , Subha Maity , Alex Gittens , Yuekai Sun , Mikhail Yurochkin

An exhaustive study on neural network language modeling (NNLM) is performed in this paper. Different architectures of basic neural network language models are described and examined. A number of different improvements over basic neural…

Computation and Language · Computer Science 2017-08-25 Dengliang Shi

Vision-language models (VLMs) have made substantial progress across a wide range of visual question answering benchmarks, spanning visual reasoning, document understanding, and multimodal dialogue. These improvements are evident in a wide…

Computer Vision and Pattern Recognition · Computer Science 2026-02-23 Dhruba Ghosh , Yuhui Zhang , Ludwig Schmidt

Artificial Neural Networks, the building blocks of AI, were inspired by the human brain's network of neurons. Over the years, these networks have evolved to replicate the complex capabilities of the brain, allowing them to handle tasks such…

Neurons and Cognition · Quantitative Biology 2025-11-11 Sanaz Saki Norouzi , Mohammad Masjedi , Pascal Hitzler
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