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Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL)…

In this paper, we address the challenge of few-shot classification in histopathology whole slide images (WSIs) by utilizing foundational vision-language models (VLMs) and slide-level prompt learning. Given the gigapixel scale of WSIs,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Devavrat Tomar , Guillaume Vray , Dwarikanath Mahapatra , Sudipta Roy , Jean-Philippe Thiran , Behzad Bozorgtabar

Multiple instance learning (MIL) models have achieved remarkable success in analyzing whole slide images (WSIs) for disease classification problems. However, with regard to gigapixel WSI classification problems, current MIL models are often…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Ziyu Su , Mostafa Rezapour , Usama Sajjad , Metin Nafi Gurcan , Muhammad Khalid Khan Niazi

General continual learning (GCL) is a broad concept to describe real-world continual learning (CL) problems, which are often characterized by online data streams without distinct transitions between tasks, i.e., blurry task boundaries. Such…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Zhiqi Kang , Liyuan Wang , Xingxing Zhang , Karteek Alahari

Multiple instance learning (MIL) is a key algorithm for classification of whole slide images (WSI). Histology WSIs can have billions of pixels, which create enormous computational and annotation challenges. Typically, such images are…

Image and Video Processing · Electrical Eng. & Systems 2021-11-03 Andriy Myronenko , Ziyue Xu , Dong Yang , Holger Roth , Daguang Xu

Deep learning techniques have been widely applied to hyperspectral image (HSI) classification and have achieved great success. However, the deep neural network model has a large parameter space and requires a large number of labeled data.…

Computer Vision and Pattern Recognition · Computer Science 2021-06-01 Qiqi Zhu , Weihuan Deng , Zhuo Zheng , Yanfei Zhong , Qingfeng Guan , Weihua Lin , Liangpei Zhang , Deren Li

Deep neural networks are increasingly applied in automated histopathology. Yet, whole-slide images (WSIs) are often acquired at gigapixel sizes, rendering them computationally infeasible to analyze entirely at high resolution. Diagnostic…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Tarun G , Naman Malpani , Gugan Thoppe , Sridharan Devarajan

Whole Slide Image (WSI) classification is often formulated as a Multiple Instance Learning (MIL) problem. Recently, Vision-Language Models (VLMs) have demonstrated remarkable performance in WSI classification. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2024-04-08 Hao Li , Ying Chen , Yifei Chen , Wenxian Yang , Bowen Ding , Yuchen Han , Liansheng Wang , Rongshan Yu

Whole slide pathology image classification presents challenges due to gigapixel image sizes and limited annotation labels, hindering model generalization. This paper introduces a prompt learning method to adapt large vision-language models…

Whole slide images (WSIs) are high-resolution, gigapixel sized images that pose significant computational challenges for traditional machine learning models due to their size and heterogeneity.In this paper, we present a scalable and…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Ravi Kant Gupta , Shounak Das , Ardhendu Sekhar , Amit Sethi

Whole Slide Image (WSI) classification remains a challenge due to their extremely high resolution and the absence of fine-grained labels. Presently, WSI classification is usually regarded as a Multiple Instance Learning (MIL) problem when…

Computer Vision and Pattern Recognition · Computer Science 2023-08-24 Hongyi Wang , Luyang Luo , Fang Wang , Ruofeng Tong , Yen-Wei Chen , Hongjie Hu , Lanfen Lin , Hao Chen

Slide-level classification for whole-slide images (WSIs) has been widely recognized as a crucial problem in digital and computational pathology. Current approaches commonly consider WSIs as a bag of cropped patches and process them via…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Doanh C. Bui , Trinh Thi Le Vuong , Jin Tae Kwak

Multiple instance learning (MIL) is a powerful approach to classify whole slide images (WSIs) for diagnostic pathology. A fundamental challenge of MIL on WSI classification is to discover the \textit{critical instances} that trigger the bag…

Computer Vision and Pattern Recognition · Computer Science 2022-09-02 Zhikang Wang , Yue Bi , Tong Pan , Xiaoyu Wang , Chris Bain , Richard Bassed , Seiya Imoto , Jianhua Yao , Jiangning Song

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). Existing approaches typically rely on frozen pre-trained models to extract instance features, neglecting the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Yi Lin , Zhengjie Zhu , Kwang-Ting Cheng , Hao Chen

Whole slide image (WSI) classification is a critical task in computational pathology. However, the gigapixel-size of such images remains a major challenge for the current state of deep-learning. Current methods rely on multiple-instance…

Computer Vision and Pattern Recognition · Computer Science 2023-10-04 Etienne Pochet , Rami Maroun , Roger Trullo

Whole slide image (WSI) classification is a critical task in computational pathology, requiring the processing of gigapixel-sized images, which is challenging for current deep-learning methods. Current state of the art methods are based on…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 Jingwei Zhang , Saarthak Kapse , Ke Ma , Prateek Prasanna , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Whole Slide Images (WSIs) are typically analyzed using multiple instance learning (MIL) methods. However, the scale and heterogeneity of WSIs generate highly redundant and dispersed information, making it difficult to identify and integrate…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Yueting Zhu , Yuehao Song , Shuai Zhang , Wenyu Liu , Xinggang Wang

Rapid progress in vision-language modeling has enabled pathology report generation from gigapixel whole-slide images, but most approaches assume static training with simultaneous access to all data. In clinical deployment, however, new…

Computer Vision and Pattern Recognition · Computer Science 2026-03-02 Pratibha Kumari , Daniel Reisenbüchler , Afshin Bozorgpour , yousef Sadegheih , Priyankar Choudhary , Dorit Merhof

The Lifelong Multi-Label (LML) image recognition builds an online class-incremental classifier in a sequential multi-label image recognition data stream. The key challenges of LML image recognition are the construction of label…

Computer Vision and Pattern Recognition · Computer Science 2022-03-14 Kaile Du , Fan Lyu , Fuyuan Hu , Linyan Li , Wei Feng , Fenglei Xu , Qiming Fu

Functional magnetic resonance imaging (fMRI) is widely used for studying and diagnosing brain disorders, with functional connectivity (FC) matrices providing powerful representations of large-scale neural interactions. However, existing…

Tissues and Organs · Quantitative Biology 2026-04-17 Qianyu Chen , Shujian Yu