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Learning and memory relies on synapses changing their strengths in response to neural activity. However there is a substantial gap between the timescales of neural electrical dynamics (1-100 ms) and organism behaviour during learning…

Neurons and Cognition · Quantitative Biology 2023-08-08 Cian O'Donnell

Neural synchronization is believed to be critical for many brain functions. It frequently exhibits temporal variability, but it is not known if this variability has a specific temporal patterning. This study explores these…

Neurons and Cognition · Quantitative Biology 2013-03-11 Sungwoo Ahn , Leonid L. Rubchinsky

Are your perceptions, memories and observational data, a statistical fluctuation out of the thermal equilibrium of the universe, having no correlation with the actual past state of the universe? Arguments are given in the literature for and…

History and Philosophy of Physics · Physics 2026-01-26 David Wolpert , Carlo Rovelli , Jordan Scharnhorst

Cortical neurons exhibit a hierarchy of timescales across brain regions in response to input stimuli, which is thought to be crucial for information processing of different temporal scales. Modeling studies suggest that both intra-regional…

Neurons and Cognition · Quantitative Biology 2024-12-24 Yang Qi , Jiexiang Wang , Weiyang Ding , Gustavo Deco , Viktor Jirsa , Wenlian Lu , Jianfeng Feng

We discuss the possibility of multiple underlying etiologies of the condition currently labeled as schizophrenia. We support this hypothesis with a theoretical model of the prefrontal-limbic system. We show how the dynamical behavior of…

Neurons and Cognition · Quantitative Biology 2008-08-19 Anca Radulescu

Understanding the neural mechanism underlying subjective representation has become a central endeavor in cognitive-neuroscience. In theories of conscious perception, stimulus gaining conscious access is usually considered as a discrete…

Neurons and Cognition · Quantitative Biology 2018-03-28 Moti Salti , Asaf Harel , Sebastien Marti

Living systems are fundamentally irreversible, breaking detailed balance and establishing an arrow of time. But how does the evident arrow of time for a whole system arise from the interactions among its multiple elements? We show that the…

Statistical Mechanics · Physics 2022-09-21 Christopher W. Lynn , Caroline M. Holmes , William Bialek , David J. Schwab

PD is linked to faster brain aging. Sex is recognized as an important factor in PD, such that males are twice as likely as females to have the disease and have more severe symptoms and a faster progression rate. Despite previous research,…

Neurons and Cognition · Quantitative Biology 2023-09-20 Iman Beheshti , Samuel Booth , Ji Hyun Ko

The Reward Prediction Error hypothesis proposes that phasic activity in the midbrain dopaminergic system reflects prediction errors needed for learning in reinforcement learning. Besides the well-documented association between dopamine and…

Neurons and Cognition · Quantitative Biology 2022-07-26 William H. Alexander , Samuel J. Gershman

Brain rhythms contribute to every aspect of brain function. Here, we study critical and resonance phenomena that precede the emergence of brain rhythms. Using an analytical approach and simulations of a cortical circuit model of neural…

Disordered Systems and Neural Networks · Physics 2015-06-12 A. V. Goltsev , M. A. Lopes , K. -E. Lee , J. F. F. Mendes

In many clinical trials studying neurodegenerative diseases such as Parkinson's disease (PD), multiple longitudinal outcomes are collected to fully explore the multidimensional impairment caused by this disease. If the outcomes deteriorate…

Applications · Statistics 2017-05-18 Jue Wang , Sheng Luo , Liang Li

Schizophrenic patients suffer from hallucination which its causality is not yet fully understood. This paper attempts to approach this mystery from the perspective of quantum mechanical theories. A novel approach has been adopted to…

Neurons and Cognition · Quantitative Biology 2017-06-13 Omid Rezania

We all are fascinated by the phenomena of intelligent behavior, as generated both by our own brains and by the brains of other animals. As physicists we would like to understand if there are some general principles that govern the structure…

Biological Physics · Physics 2007-05-23 William Bialek

Despite intense recent research, the neural correlates of conscious visual perception remain elusive. The most established paradigm for studying brain mechanisms underlying conscious perception is to keep the physical sensory inputs…

Neurons and Cognition · Quantitative Biology 2014-03-21 Qi Li , Zachary Hill , Biyu J. He

Time-reversal symmetry breaking is a key feature of nearly all natural sounds, caused by the physics of sound production. While attention has been paid to the response of the auditory system to "natural stimuli," very few psychophysical…

Neurons and Cognition · Quantitative Biology 2013-01-04 Jacob N. Oppenheim , Pavel Isakov , Marcelo O. Magnasco

The critical brain hypothesis posits that neural circuitry operates near criticality to reap the computational benefits of accessing a wide range of timescales. The theory of critical phenomena generally predicts heavy-tailed (power-law)…

Neurons and Cognition · Quantitative Biology 2025-12-23 Jacob T. Crosser , Braden A. W. Brinkman

Time perception research has advanced significantly over the years. However, some areas remain largely unexplored. This study addresses two such under-explored areas in timing research: (1) A quantitative analysis of time perception at an…

Human-Computer Interaction · Computer Science 2024-12-18 Amrapali Pednekar , Alvaro Garrido , Yara Khaluf , Pieter Simoens

We investigate temporal correlations in the simplest measurement scenario, i.e., that of a physical system on which the same measurement is performed at different times, producing a sequence of dichotomic outcomes. The resource for…

Quantum Physics · Physics 2022-01-19 Lucas B. Vieira , Costantino Budroni

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor dysfunction, psychiatric disturbances, and cognitive decline. The onset of HD is marked by severe motor impairment, which may be predicted…

Methodology · Statistics 2026-02-17 Yue Zhan , Cheng Zheng , Ying Zhang

Cardiac diseases are the principal cause of human morbidity and mortality in the western world. The electric potential of the heart is a highly complex signal emerging as a result of nontrivial flow conduction, hierarchical structuring and…

Data Analysis, Statistics and Probability · Physics 2012-04-19 Oriol Pont , Michel Haïssaguerre , Hussein Yahia , Nicolas Derval , Mélèze Hocini
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