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The growing availability of large health databases has expanded the use of observational studies for comparative effectiveness research. Unlike randomized trials, observational studies must adjust for systematic differences in patient…

Methodology · Statistics 2026-01-21 Haidong Lu , Fan Li , Laine E. Thomas , Fan Li

Effective water resource management requires information on water availability, both in terms of quality and quantity, spatially and temporally. In this paper, we study the methodology behind Transfer Learning (TL) through fine-tuning and…

Machine Learning · Computer Science 2021-12-07 Roland Oruche , Lisa Egede , Tracy Baker , Fearghal O'Donncha

Over the past few decades, statistical methods for causal inference have made impressive strides, enabling progress across a range of scientific fields. However, much of this methodological development has been confined to individual…

Methodology · Statistics 2025-09-30 Wenqi Shi , José R. Zubizarreta

Recent studies have shown effectiveness in using neural networks for Chinese word segmentation. However, these models rely on large-scale data and are less effective for low-resource datasets because of insufficient training data. We…

Computation and Language · Computer Science 2017-09-15 Jingjing Xu , Xu Sun

Retrosynthesis is a problem to infer reactant compounds to synthesize a given product compound through chemical reactions. Recent studies on retrosynthesis focus on proposing more sophisticated prediction models, but the dataset to feed the…

Machine Learning · Computer Science 2020-10-05 Katsuhiko Ishiguro , Kazuya Ujihara , Ryohto Sawada , Hirotaka Akita , Masaaki Kotera

We present a simple method to improve neural translation of a low-resource language pair using parallel data from a related, also low-resource, language pair. The method is based on the transfer method of Zoph et al., but whereas their…

Computation and Language · Computer Science 2017-09-22 Toan Q. Nguyen , David Chiang

Chronic obstructive pulmonary disease (COPD) is a lung disease which can be quantified using chest computed tomography (CT) scans. Recent studies have shown that COPD can be automatically diagnosed using weakly supervised learning of…

Computer Vision and Pattern Recognition · Computer Science 2017-11-27 Veronika Cheplygina , Isabel Pino Peña , Jesper Holst Pedersen , David A. Lynch , Lauge Sørensen , Marleen de Bruijne

Machine learning (ML) holds great potential for accurately forecasting treatment outcomes over time, which could ultimately enable the adoption of more individualized treatment strategies in many practical applications. However, a…

Machine Learning · Statistics 2023-06-08 Toon Vanderschueren , Alicia Curth , Wouter Verbeke , Mihaela van der Schaar

Biomedical researchers usually study the effects of certain exposures on disease risks among a well-defined population. To achieve this goal, the gold standard is to design a trial with an appropriate sample from that population. Due to the…

Applications · Statistics 2019-11-18 Cheng Zheng , Sayan Dasgupta , Yuxiang Xie , Asad Haris , Ying Qing Chen

Large-scale pre-trained language models (LLMs) have demonstrated exceptional performance in various natural language processing (NLP) tasks. However, the massive size of these models poses huge challenges for their deployment in real-world…

Computation and Language · Computer Science 2023-10-25 Jiduan Liu , Jiahao Liu , Qifan Wang , Jingang Wang , Xunliang Cai , Dongyan Zhao , Ran Lucien Wang , Rui Yan

Infectious disease dynamics operate across multiple biological scales, with within-host viral dynamics being a key driver of between-host transmission. However, while models that explicitly link these scales exist, none have been developed…

Applications · Statistics 2026-04-23 Dylan J. Morris , Lauren Kennedy , Andrew J. Black

Despite the impressive advancements achieved using deep-learning for functional brain activity analysis, the heterogeneity of functional patterns and scarcity of imaging data still pose challenges in tasks such as prediction of future onset…

Image and Video Processing · Electrical Eng. & Systems 2023-12-25 Wenhui Cui , Haleh Akrami , Ganning Zhao , Anand A. Joshi , Richard M. Leahy

We propose a new framework for binary classification in transfer learning settings where both covariate and label distributions may shift between source and target domains. Unlike traditional covariate shift or label shift assumptions, we…

Methodology · Statistics 2025-09-29 Manli Cheng , Subha Maity , Qinglong Tian , Pengfei Li

Deep learning enables the modelling of high-resolution histopathology whole-slide images (WSI). Weakly supervised learning of tile-level data is typically applied for tasks where labels only exist on the patient or WSI level (e.g. patient…

Image and Video Processing · Electrical Eng. & Systems 2025-06-09 Abhinav Sharma , Bojing Liu , Mattias Rantalainen

Clinical decision support tools built on electronic health records often experience performance drift due to temporal population shifts, particularly when changes in the clinical environment initially affect only a subset of patients,…

Machine Learning · Computer Science 2025-12-16 Mengying Yan , Ziye Tian , Siqi Li , Nan Liu , Benjamin A. Goldstein , Molei Liu , Chuan Hong

Explainability of neural network prediction is essential to understand feature importance and gain interpretable insight into neural network performance. However, explanations of neural network outcomes are mostly limited to visualization,…

Machine Learning · Computer Science 2023-07-13 Arnab Neelim Mazumder , Niall Lyons , Ashutosh Pandey , Avik Santra , Tinoosh Mohsenin

Multi-regional clinical trials (MRCTs) are central to global drug development, enabling evaluation of treatment effects across diverse populations. A key challenge is valid and efficient inference for a region-specific estimand when the…

Methodology · Statistics 2026-02-04 Chenxi Li , Ke Zhu , Shu Yang , Xiaofei Wang

Transfer learning is widely used to adapt large pretrained models to new tasks with only a small amount of new data. However, a challenge persists -- the features from the original task often do not fully cover what is needed for unseen…

Machine Learning · Computer Science 2026-02-10 Xingyu Alice Yang , Jianyu Zhang , Léon Bottou

Transfer learning is the predominant paradigm for training deep networks on small target datasets. Models are typically pretrained on large ``upstream'' datasets for classification, as such labels are easy to collect, and then finetuned on…

Computer Vision and Pattern Recognition · Computer Science 2022-07-11 Anurag Arnab , Xuehan Xiong , Alexey Gritsenko , Rob Romijnders , Josip Djolonga , Mostafa Dehghani , Chen Sun , Mario Lučić , Cordelia Schmid

Transfer learning is a valuable tool in deep learning as it allows propagating information from one "source dataset" to another "target dataset", especially in the case of a small number of training examples in the latter. Yet,…

Machine Learning · Computer Science 2023-06-13 Daniel Jakubovitz , David Uliel , Miguel Rodrigues , Raja Giryes