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Machine learning in production needs to balance multiple objectives: This is particularly evident in ranking or recommendation models, where conflicting objectives such as user engagement, satisfaction, diversity, and novelty must be…

Human-Computer Interaction · Computer Science 2025-02-11 Chenyang Yang , Tesi Xiao , Michael Shavlovsky , Christian Kästner , Tongshuang Wu

This study aims to optimize the evaluation metric of multimodal multi-objective optimization problems using a Regionalized Metric Framework, which provides a certain boost to research in this field. Existing evaluation metrics usually use…

Neural and Evolutionary Computing · Computer Science 2025-06-03 Jintai Chen , Fangqing Liu , Xueming Yan , Han Huang

The keyboard design is a novel phase I dose-finding method that is simple and has good operating characteristics. This paper studies theoretical properties of the keyboard design, including the optimality of its decision rules, coherence in…

Methodology · Statistics 2017-12-20 Haitao Pan , Ruitao Lin , Ying Yuan

How should one jointly design tests and the arrangement of agencies to administer these tests (testing procedure)? To answer this question, we analyze a model where a principal must use multiple tests to screen an agent with a…

Theoretical Economics · Economics 2025-02-19 Xiaoyun Qiu , Liren Shan

Antibody-based therapeutics-including antibody-drug conjugates (ADCs), bispecific antibodies, and novel formats-are reshaping oncology, yet key determinants of efficacy, safety, and manufacturability frequently emerge after conjugation and…

Soft Condensed Matter · Physics 2026-05-18 Alberto Ocana , Jorge R. Espinosa

Nowadays, more and more clinical trials choose combinational agents as the intervention to achieve better therapeutic responses. However, dose-finding for combinational agents is much more complicated than single agent as the full order of…

Applications · Statistics 2022-08-05 Shu Wang , Ji-Hyun Lee

Reusing ontologies in practice is still very challenging, especially when multiple ontologies are (jointly) involved. Moreover, despite recent advances, the realization of systematic ontology quality assurance remains a difficult problem.…

Software Engineering · Computer Science 2022-09-20 Piotr Sowinski , Katarzyna Wasielewska-Michniewska , Maria Ganzha , Marcin Paprzycki , Costin Badica

Related or ideal follow-up suggestions to a web query in search engines are often optimized based on several different parameters -- relevance to the original query, diversity, click probability etc. One or many rankers may be trained to…

Information Retrieval · Computer Science 2021-05-24 Harsh Kohli

This paper considers the problem of parameter identification for a multirobot system. We wish to understand when is it feasible for an adversarial observer to reverse-engineer the parameters of tasks being performed by a team of robots by…

Optimization and Control · Mathematics 2020-09-30 Jaskaran Singh Grover , Changliu Liu , Katia Sycara

Implementing resource efficient energy management systems in facilities and buildings becomes increasingly important in the transformation to a sustainable society. However, selecting a suitable configuration based on multiple, typically…

Machine Learning · Computer Science 2024-03-26 Felix Lanfermann , Qiqi Liu , Yaochu Jin , Sebastian Schmitt

In psychological research often paired comparisons are used in which either full or partial profiles of the alternatives described by a common set of two-level attributes are presented. For this situation the problem of finding optimal…

Methodology · Statistics 2019-08-20 Eric Nyarko

A multi-task learning (MTL) system aims at solving multiple related tasks at the same time. With a fixed model capacity, the tasks would be conflicted with each other, and the system usually has to make a trade-off among learning all of…

Machine Learning · Computer Science 2021-02-16 Xi Lin , Zhiyuan Yang , Qingfu Zhang , Sam Kwong

Modern advanced manufacturing and advanced materials design often require searches of relatively high-dimensional process control parameter spaces for settings that result in optimal structure, property, and performance parameters. The…

Machine Learning · Computer Science 2024-07-25 Carlo Graziani , Marieme Ngom

Adjustable hyperparameters of machine learning models typically impact various key trade-offs such as accuracy, fairness, robustness, or inference cost. Our goal in this paper is to find a configuration that adheres to user-specified limits…

Machine Learning · Computer Science 2023-12-05 Bracha Laufer-Goldshtein , Adam Fisch , Regina Barzilay , Tommi Jaakkola

Computational methods in drug repositioning can help to conserve resources. In particular, methods based on biological networks are showing promise. Considering only the network topology and knowledge on drug target genes is not sufficient…

Molecular Networks · Quantitative Biology 2025-04-02 Atte Aalto , La Mi , Diego A. Blanco-Mora , Jorge Goncalves

Architecture optimization is the process of automatically generating design options, typically to enhance software's quantifiable quality attributes, such as performance and reliability. Multi-objective optimization approaches have been…

Software Engineering · Computer Science 2024-01-31 Daniele Di Pompeo , Michele Tucci

The specification, design, and assurance of safety encompasses various concepts and best practices, subject of reuse in form of patterns. This work summarizes applied research on such concepts and practices with a focus on the last two…

Software Engineering · Computer Science 2019-02-15 Mario Gleirscher , Stefan Kugele

This thesis investigates the use of problem-specific knowledge to enhance a genetic algorithm approach to multiple-choice optimisation problems.It shows that such information can significantly enhance performance, but that the choice of…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin

In many real-world applications, evaluating the quality of instances is costly and time-consuming, e.g., human feedback and physics simulations, in contrast to proposing new instances. In particular, this is even more critical in…

When selecting from a list of potential candidates, it is important to ensure not only that the selected items are of high quality, but also that they are sufficiently dissimilar so as to both avoid redundancy and to capture a broader range…

Methodology · Statistics 2026-02-25 Yash Nair , Ying Jin , James Yang , Emmanuel Candes