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Robust and accurate segmentation of scenes has become one core functionality in various visual recognition and navigation tasks. This has inspired the recent development of Segment Anything Model (SAM), a foundation model for general mask…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Aoran Xiao , Weihao Xuan , Heli Qi , Yun Xing , Naoto Yokoya , Shijian Lu

Image registration and in particular deformable registration methods are pillars of medical imaging. Inspired by the recent advances in deep learning, we propose in this paper, a novel convolutional neural network architecture that couples…

Computer Vision and Pattern Recognition · Computer Science 2018-09-18 Stergios Christodoulidis , Mihir Sahasrabudhe , Maria Vakalopoulou , Guillaume Chassagnon , Marie-Pierre Revel , Stavroula Mougiakakou , Nikos Paragios

Recent deep learning-based methods have shown promising results and runtime advantages in deformable image registration. However, analyzing the effects of hyperparameters and searching for optimal regularization parameters prove to be too…

Computer Vision and Pattern Recognition · Computer Science 2021-07-06 Tony C. W. Mok , Albert C. S. Chung

The Segment Anything Model (SAM) exhibits a capability to segment a wide array of objects in natural images, serving as a versatile perceptual tool for various downstream image segmentation tasks. In contrast, medical image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Yizhe Zhang , Tao Zhou , Shuo Wang , Ye Wu , Pengfei Gu , Danny Z. Chen

Volumetric medical image segmentation is pivotal in enhancing disease diagnosis, treatment planning, and advancing medical research. While existing volumetric foundation models for medical image segmentation, such as SAM-Med3D and SegVol,…

Computer Vision and Pattern Recognition · Computer Science 2024-07-15 Guoan Wang , Jin Ye , Junlong Cheng , Tianbin Li , Zhaolin Chen , Jianfei Cai , Junjun He , Bohan Zhuang

Sharpness-Aware Minimization (SAM) has attracted considerable attention for its effectiveness in improving generalization in deep neural network training by explicitly minimizing sharpness in the loss landscape. Its success, however, relies…

Machine Learning · Computer Science 2025-06-16 Sungbin Shin , Dongyeop Lee , Maksym Andriushchenko , Namhoon Lee

Foundation medical segmentation models, with MedSAM being the most popular, have achieved promising performance across organs and lesions. However, MedSAM still suffers from compromised performance on specific lesions with intricate…

Quantitative Methods · Quantitative Biology 2025-07-16 Kecheng Chen , Xinyu Luo , Tiexin Qin , Jie Liu , Hui Liu , Victor Ho Fun Lee , Hong Yan , Haoliang Li

Sharpness-Aware Minimization (SAM) has emerged as a powerful method for improving generalization in machine learning models by minimizing the sharpness of the loss landscape. However, despite its success, several important questions…

Optimization and Control · Mathematics 2025-03-05 Dimitris Oikonomou , Nicolas Loizou

As the rapid development of computer vision and the emergence of powerful network backbones and architectures, the application of deep learning in medical imaging has become increasingly significant. Unlike natural images, medical images…

Image and Video Processing · Electrical Eng. & Systems 2026-04-10 Guoqing Zhang , Jingyun Yang , Yang Li

This article discusses the opportunities, applications and future directions of large-scale pre-trained models, i.e., foundation models, for analyzing medical images. Medical foundation models have immense potential in solving a wide range…

Image and Video Processing · Electrical Eng. & Systems 2023-11-23 Shaoting Zhang , Dimitris Metaxas

Sharpness-aware minimization (SAM) was proposed to reduce sharpness of minima and has been shown to enhance generalization performance in various settings. In this work we show that perturbing only the affine normalization parameters…

Machine Learning · Computer Science 2023-11-20 Maximilian Mueller , Tiffany Vlaar , David Rolnick , Matthias Hein

Deformable image registration aims to find a dense non-linear spatial correspondence between a pair of images, which is a crucial step for many medical tasks such as tumor growth monitoring and population analysis. Recently, Deep Neural…

Image and Video Processing · Electrical Eng. & Systems 2025-01-09 Mingyuan Meng , Michael Fulham , Dagan Feng , Lei Bi , Jinman Kim

The unprecedented developments in segmentation foundational models have become a dominant force in the field of computer vision, introducing a multitude of previously unexplored capabilities in a wide range of natural images and videos.…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Yichi Zhang , Zhenrong Shen

Domain generalization (DG) aims to learn models that perform well on unseen target domains by training on multiple source domains. Sharpness-Aware Minimization (SAM), known for finding flat minima that improve generalization, has therefore…

Machine Learning · Statistics 2025-07-01 Youngjun Song , Youngsik Hwang , Jonghun Lee , Heechang Lee , Dong-Young Lim

Sharpness-aware minimization (SAM) has been instrumental in improving deep neural network training by minimizing both the training loss and the sharpness of the loss landscape, leading the model into flatter minima that are associated with…

Machine Learning · Computer Science 2024-10-03 Van-Anh Nguyen , Quyen Tran , Tuan Truong , Thanh-Toan Do , Dinh Phung , Trung Le

Parametric spatial transformation models have been successfully applied to image registration tasks. In such models, the transformation of interest is parameterized by a fixed set of basis functions as for example B-splines. Each basis…

Computer Vision and Pattern Recognition · Computer Science 2019-06-25 Robin Sandkühler , Simon Andermatt , Grzegorz Bauman , Sylvia Nyilas , Christoph Jud , Philippe C. Cattin

Recent studies on deep neural networks show that flat minima of the loss landscape correlate with improved generalization. Sharpness-aware minimization (SAM) efficiently finds flat regions by updating the parameters according to the…

Machine Learning · Computer Science 2025-02-13 Albert Kjøller Jacobsen , Georgios Arvanitidis

The Segment Anything Model (SAM) is the first foundation model for general image segmentation. It has achieved impressive results on various natural image segmentation tasks. However, medical image segmentation (MIS) is more challenging…

Image and Video Processing · Electrical Eng. & Systems 2024-01-18 Yuhao Huang , Xin Yang , Lian Liu , Han Zhou , Ao Chang , Xinrui Zhou , Rusi Chen , Junxuan Yu , Jiongquan Chen , Chaoyu Chen , Sijing Liu , Haozhe Chi , Xindi Hu , Kejuan Yue , Lei Li , Vicente Grau , Deng-Ping Fan , Fajin Dong , Dong Ni

Image registration aims to establish spatial correspondence across pairs, or groups of images, and is a cornerstone of medical image computing and computer-assisted-interventions. Currently, most deep learning-based registration methods…

Image and Video Processing · Electrical Eng. & Systems 2021-07-12 Xiang Chen , Nishant Ravikumar , Yan Xia , Alejandro F Frangi

Semi-supervised learning has attracted much attention due to its less dependence on acquiring abundant annotations from experts compared to fully supervised methods, which is especially important for medical image segmentation which…

Computer Vision and Pattern Recognition · Computer Science 2024-10-24 Yichi Zhang , Jin Yang , Yuchen Liu , Yuan Cheng , Yuan Qi