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A genome read data set can be quickly and efficiently remapped from one reference to another similar reference (e.g., between two reference versions or two similar species) using a variety of tools, e.g., the commonly-used CrossMap tool.…

Genomics · Quantitative Biology 2023-11-21 Jeremie S. Kim , Can Firtina , Meryem Banu Cavlak , Damla Senol Cali , Can Alkan , Onur Mutlu

Exploratory analysis of high-dimensional data rarely stops at a single embedding. In practice, analysts rerun dimensionality reduction after changing preprocessing, subsets, or hyperparameters, and standard nonlinear methods can quickly…

Machine Learning · Computer Science 2026-05-13 Hongmin Li

Speculative Decoding has gained popularity as an effective technique for accelerating the auto-regressive inference process of Large Language Models. However, Speculative Decoding entirely relies on the availability of efficient draft…

Computation and Language · Computer Science 2025-06-06 Ofir Zafrir , Igor Margulis , Dorin Shteyman , Shira Guskin , Guy Boudoukh

Parallel Speculative Decoding (PSD) accelerates traditional Speculative Decoding (SD) by overlapping draft generation with verification. However, it remains hampered by two fundamental challenges: (1) a theoretical speedup ceiling dictated…

Computation and Language · Computer Science 2026-04-15 Yuhao Shen , Tianyu Liu , Junyi Shen , Jinyang Wu , Quan Kong , Li Huan , Cong Wang

Motivation: Illumina DNA sequencing is now the predominant source of raw genomic data, and data volumes are growing rapidly. Bioinformatic analysis pipelines are having trouble keeping pace. A common bottleneck in such pipelines is the…

Genomics · Quantitative Biology 2014-09-09 Gregory G. Faust , Ira M. Hall

We present fastrerandomize, an R package for fast, scalable rerandomization in experimental design. Rerandomization improves precision by discarding treatment assignments that fail a prespecified covariate-balance criterion, but existing…

Computation · Statistics 2026-01-09 Rebecca Goldstein , Connor T. Jerzak , Aniket Kamat , Fucheng Warren Zhu

Chain-of-Thought reasoning significantly improves the performance of large language models on complex tasks, but incurs high inference latency due to long generation traces. Step-level speculative reasoning aims to mitigate this cost, yet…

Computation and Language · Computer Science 2026-02-24 Siran Liu , Cyril Y. He

Speculative decoding accelerates memory-bound LLM inference without quality degradation by using a fast drafter to propose multiple candidate tokens and the target model to verify them in parallel. However, conventional sequential…

Computation and Language · Computer Science 2026-05-20 Yaojie Zhang , Jianuo Huang , Junlong Ke , Yuhang Han , Yongji Long , Tianchen Zhao , Biqing Qi , Linfeng Zhang

Accelerating molecular docking -- the process of predicting how molecules bind to protein targets -- could boost small-molecule drug discovery and revolutionize medicine. Unfortunately, current molecular docking tools are too slow to screen…

Speculative decoding has emerged as a widely adopted method to accelerate large language model inference without sacrificing the quality of the model outputs. While this technique has facilitated notable speed improvements by enabling…

Computation and Language · Computer Science 2025-02-12 Jacob K Christopher , Brian R Bartoldson , Tal Ben-Nun , Michael Cardei , Bhavya Kailkhura , Ferdinando Fioretto

The Mixup scheme suggests mixing a pair of samples to create an augmented training sample and has gained considerable attention recently for improving the generalizability of neural networks. A straightforward and widely used extension of…

Computer Vision and Pattern Recognition · Computer Science 2021-12-17 Joonhyung Park , June Yong Yang , Jinwoo Shin , Sung Ju Hwang , Eunho Yang

Data augmentation with \textbf{Mixup} has been proven an effective method to regularize the current deep neural networks. Mixup generates virtual samples and corresponding labels at once through linear interpolation. However, this one-stage…

Machine Learning · Computer Science 2022-06-07 Xiangjin Xie , Yangning Li , Wang Chen , Kai Ouyang , Li Jiang , Haitao Zheng

It has been well established that increasing scale in deep transformer networks leads to improved quality and performance. However, this increase in scale often comes with prohibitive increases in compute cost and inference latency. We…

Machine Learning · Computer Science 2023-10-05 Cenk Baykal , Dylan Cutler , Nishanth Dikkala , Nikhil Ghosh , Rina Panigrahy , Xin Wang

In this paper, we propose a new framework for designing fast parallel algorithms for fundamental statistical subset selection tasks that include feature selection and experimental design. Such tasks are known to be weakly submodular and are…

Machine Learning · Computer Science 2021-04-02 Sharon Qian , Yaron Singer

Masked Diffusion Models (MDMs) offer a promising alternative to autoregressive language models by enabling parallel token generation and bidirectional context modeling. However, their inference speed is significantly limited by the…

Machine Learning · Computer Science 2026-04-08 Satyam Goyal , Kushal Patel , Tanush Mittal , Arjun Laxman

Speculative decoding is an effective and lossless method for Large Language Model (LLM) inference acceleration. It employs a smaller model to generate a draft token sequence, which is then verified by the original base model. In multi-GPU…

Machine Learning · Computer Science 2025-12-09 Yize Wu , Ke Gao , Ling Li , Yanjun Wu

Dropout is a common regularisation technique in deep learning that improves generalisation. Even though it introduces sparsity and thus potential for higher throughput, it usually cannot bring speed-ups on GPUs due to its unstructured…

Machine Learning · Computer Science 2024-11-05 Andy Lo

Several techniques have been proposed to detect vulnerable Spectre gadgets in widely deployed commercial software. Unfortunately, detection techniques proposed so far rely on hand-written rules which fall short in covering subtle variations…

Cryptography and Security · Computer Science 2021-03-29 M. Caner Tol , Berk Gulmezoglu , Koray Yurtseven , Berk Sunar

Speculative decoding (SD) accelerates large language model inference by employing a faster draft model for generating multiple tokens, which are then verified in parallel by the larger target model, resulting in the text generated according…

Flow-matching models deliver state-of-the-art fidelity in image and video generation, but the inherent sequential denoising process renders them slower. Existing acceleration methods like distillation, trajectory truncation, and consistency…

Computer Vision and Pattern Recognition · Computer Science 2026-02-12 Divya Jyoti Bajpai , Dhruv Bhardwaj , Soumya Roy , Tejas Duseja , Harsh Agarwal , Aashay Sandansing , Manjesh Kumar Hanawal
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