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Recent advances in large language models (LLMs) and biomedical foundation models (BioFMs) have achieved strong results in biological text reasoning, molecular modeling, and single-cell analysis, yet they remain siloed in disjoint embedding…

Quantitative Methods · Quantitative Biology 2025-10-03 Ching-Huei Tsou , Michal Ozery-Flato , Ella Barkan , Diwakar Mahajan , Ben Shapira

This study evaluates the performance of large language models (LLMs) and the HINT model in predicting clinical trial outcomes, focusing on metrics including Balanced Accuracy, Matthews Correlation Coefficient (MCC), Recall, and Specificity.…

Machine Learning · Computer Science 2025-03-19 Shuyi Jin , Lu Chen , Hongru Ding , Meijie Wang , Lun Yu

Multimodal large language models (MLLMs) have made rapid progress, yet their reasoning ability often lags behind strong text-only LLMs. Bridging this gap typically requires large-scale multimodal reasoning data or reinforcement learning,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Chao Huang , Zeliang Zhang , Jiang Liu , Ximeng Sun , Jialian Wu , Xiaodong Yu , Ze Wang , Chenliang Xu , Emad Barsoum , Zicheng Liu

We introduce LAMPO, a novel paradigm that leverages Large Language Models (LLMs) for solving few-shot multi-class ordinal classification tasks. Unlike conventional methods, which concatenate all demonstration examples with the test instance…

Machine Learning · Computer Science 2024-08-08 Zhen Qin , Junru Wu , Jiaming Shen , Tianqi Liu , Xuanhui Wang

Pre-trained language models (PLMs) were considered to be able to store relational knowledge present in the training data. However, some relational knowledge seems to be discarded unsafely in PLMs due to \textbf{report bias}: low-frequency…

Computation and Language · Computer Science 2023-05-25 Hongbo Zhang , Xiang Wan , Benyou Wang

Tabular data contains rich structural semantics and plays a crucial role in organizing and manipulating information. Recent methods employ Multi-modal Large Language Models (MLLMs) to address table-related tasks across various modalities of…

Computation and Language · Computer Science 2026-02-17 Haolan Wang , Zhenghao Liu , Xinze Li , Xiaocui Yang , Yu Gu , Yukun Yan , Qi Shi , Fangfang Li , Chong Chen , Ge Yu

Recent advancements in Large Language Models (LLMs) have been remarkable, with new models consistently surpassing their predecessors. These advancements are underpinned by extensive research on various training mechanisms. Among these,…

Computation and Language · Computer Science 2024-12-12 Hansle Gwon , Imjin Ahn , Young-Hak Kim , Sanghyun Park , Tae Joon Jun

Recently, Multimodal Large Language Models (MLLMs) that enable Large Language Models (LLMs) to interpret images through visual instruction tuning have achieved significant success. However, existing visual instruction tuning methods only…

Computer Vision and Pattern Recognition · Computer Science 2023-09-15 Chi Chen , Ruoyu Qin , Fuwen Luo , Xiaoyue Mi , Peng Li , Maosong Sun , Yang Liu

Recent research has shown that large language models (LLMs) can achieve remarkable translation performance through supervised fine-tuning (SFT) using only a small amount of parallel data. However, SFT simply instructs the model to imitate…

Computation and Language · Computer Science 2024-08-30 Dawei Zhu , Sony Trenous , Xiaoyu Shen , Dietrich Klakow , Bill Byrne , Eva Hasler

Recent advancements in open-source multi-modal large language models (MLLMs) have primarily focused on enhancing foundational capabilities, leaving a significant gap in human preference alignment. This paper introduces OmniAlign-V, a…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Xiangyu Zhao , Shengyuan Ding , Zicheng Zhang , Haian Huang , Maosong Cao , Weiyun Wang , Jiaqi Wang , Xinyu Fang , Wenhai Wang , Guangtao Zhai , Haodong Duan , Hua Yang , Kai Chen

The use of machine learning (ML) techniques in the biomedical field has become increasingly important, particularly with the large amounts of data generated by the aftermath of the COVID-19 pandemic. However, due to the complex nature of…

Machine Learning · Computer Science 2023-03-17 Anthony Onoja , Francesco Raimondi

Accurate and interpretable multi-disease diagnosis remains a critical challenge in medical research, particularly when leveraging heterogeneous multimodal medical data. Current approaches often rely on single-modal data, limiting their…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Yuting Zhang , Kaishen Yuan , Hao Lu , Yutao Yue , Jintai Chen , Kaishun Wu

In many-task optimization scenarios, surrogate models are valuable for mitigating the computational burden of repeated fitness evaluations across tasks. This study proposes a novel meta-surrogate framework to assist many-task optimization,…

Machine Learning · Computer Science 2026-02-05 Xian-Rong Zhang , Yue-Jiao Gong , Yuan-Ting Zhong , Ting Huang , Jun Zhang

Pre-trained multilingual language models such as mBERT have shown immense gains for several natural language processing (NLP) tasks, especially in the zero-shot cross-lingual setting. Most, if not all, of these pre-trained models rely on…

Computation and Language · Computer Science 2020-10-26 Aditi Chaudhary , Karthik Raman , Krishna Srinivasan , Jiecao Chen

Understanding brain disorders is crucial for accurate clinical diagnosis and treatment. Recent advances in Multimodal Large Language Models (MLLMs) offer a promising approach to interpreting medical images with the support of text…

Image and Video Processing · Electrical Eng. & Systems 2025-06-03 Jing Zhang , Xiaowei Yu , Yanjun Lyu , Lu Zhang , Tong Chen , Chao Cao , Yan Zhuang , Minheng Chen , Tianming Liu , Dajiang Zhu

Large Language Models (LLMs) have demonstrated remarkable capabilities through pretraining and alignment. However, superior short-context LLMs may underperform in long-context scenarios due to insufficient long-context alignment. This…

Computation and Language · Computer Science 2025-03-04 Guanzheng Chen , Xin Li , Michael Qizhe Shieh , Lidong Bing

This study introduces an evaluation framework for multimodal models in medical imaging diagnostics. We developed a pipeline incorporating data preprocessing, model inference, and preference-based evaluation, expanding an initial set of 500…

Image and Video Processing · Electrical Eng. & Systems 2024-12-10 Cailian Ruan , Chengyue Huang , Yahe Yang

We introduce a new dataset, MELINDA, for Multimodal biomEdicaL experImeNt methoD clAssification. The dataset is collected in a fully automated distant supervision manner, where the labels are obtained from an existing curated database, and…

Computation and Language · Computer Science 2020-12-18 Te-Lin Wu , Shikhar Singh , Sayan Paul , Gully Burns , Nanyun Peng

As multimodal large models (MLLMs) continue to advance across challenging tasks, a key question emerges: What essential capabilities are still missing? A critical aspect of human learning is continuous interaction with the environment --…

Multimodal large language models (MLLMs), initiated with a trained LLM, first align images with text and then fine-tune on multimodal mixed inputs. However, the MLLM catastrophically forgets the text-only instructions, which do not include…

Computation and Language · Computer Science 2024-06-06 Yi-Kai Zhang , Shiyin Lu , Yang Li , Yanqing Ma , Qing-Guo Chen , Zhao Xu , Weihua Luo , Kaifu Zhang , De-Chuan Zhan , Han-Jia Ye