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Recent studies show that deep learning models achieve good performance on medical imaging tasks such as diagnosis prediction. Among the models, multimodality has been an emerging trend, integrating different forms of data such as chest…

Machine Learning · Computer Science 2022-02-10 Haodi Zhang , Chenyu Xu , Peirou Liang , Ke Duan , Hao Ren , Weibin Cheng , Kaishun Wu

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

The fast simulation of dynamical systems is a key challenge in many scientific and engineering applications, such as weather forecasting, disease control, and drug discovery. With the recent success of deep learning, there is increasing…

Machine Learning · Computer Science 2024-10-02 Zezheng Song , Jiaxin Yuan , Haizhao Yang

Preference alignment is pivotal for empowering large language models (LLMs) to generate helpful and harmless responses. However, the performance of preference alignment is highly sensitive to the prevalent noise in the preference data.…

Machine Learning · Computer Science 2024-05-29 Xize Liang , Chao Chen , Shuang Qiu , Jie Wang , Yue Wu , Zhihang Fu , Zhihao Shi , Feng Wu , Jieping Ye

Large language models (LLMs) have demonstrated remarkable performance in a wide range of natural language tasks. However, as these models continue to grow in size, they face significant challenges in terms of computational costs.…

Computation and Language · Computer Science 2023-08-08 Ankush Agarwal , Sakharam Gawade , Amar Prakash Azad , Pushpak Bhattacharyya

Preference learning in Large Language Models (LLMs) has advanced significantly, yet existing methods remain limited by modest performance gains, high computational costs, hyperparameter sensitivity, and insufficient modeling of global…

Computation and Language · Computer Science 2026-04-03 Liang Zhu , Yuelin Bai , Xiankun Ren , Jiaxi Yang , Lei Zhang , Feiteng Fang , Hamid Alinejad-Rokny , Minghuan Tan , Min Yang

The remarkable multimodal capabilities and interactive experience of GPT-4o underscore their necessity in practical applications, yet open-source models rarely excel in both areas. In this paper, we introduce VITA, the first-ever…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Chaoyou Fu , Haojia Lin , Zuwei Long , Yunhang Shen , Yuhang Dai , Meng Zhao , Yi-Fan Zhang , Shaoqi Dong , Yangze Li , Xiong Wang , Haoyu Cao , Di Yin , Long Ma , Xiawu Zheng , Rongrong Ji , Yunsheng Wu , Ran He , Caifeng Shan , Xing Sun

Current multimodal large language models (MLLMs) struggle with fine-grained or precise understanding of visuals although they give comprehensive perception and reasoning in a spectrum of vision applications. Recent studies either develop…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Ziang Yan , Zhilin Li , Yinan He , Chenting Wang , Kunchang Li , Xinhao Li , Xiangyu Zeng , Zilei Wang , Yali Wang , Yu Qiao , Limin Wang , Yi Wang

Aligning large language models (LLMs) with diverse and multifaceted user preferences is a fundamental challenge in personalized AI systems. Existing multi-objective alignment methods either rely on costly training or require pre-trained…

Computation and Language · Computer Science 2026-05-26 Linhao Luo , Thuy-Trang Vu , Van-Anh Nguyen , Junae Kim , Gholamreza Haffari , Dinh Phung

Deploying large language models (LLMs) to real scenarios for domain-specific question answering (QA) is a key thrust for LLM applications, which poses numerous challenges, especially in ensuring that responses are both accommodating to user…

Computation and Language · Computer Science 2024-06-11 Yichi Zhang , Zhuo Chen , Yin Fang , Yanxi Lu , Fangming Li , Wen Zhang , Huajun Chen

Vision-language foundation models (VLMs) have shown great potential in feature transfer and generalization across a wide spectrum of medical-related downstream tasks. However, fine-tuning these models is resource-intensive due to their…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Ye Du , Nanxi Yu , Shujun Wang

Multimodal large language models (MLLMs) typically extract visual features from the final layers of a pretrained Vision Transformer (ViT). This widespread deep-layer bias, however, is largely driven by empirical convention rather than…

Computer Vision and Pattern Recognition · Computer Science 2025-10-13 Haoran Chen , Junyan Lin , Xinghao Chen , Yue Fan , Jianfeng Dong , Xin Jin , Hui Su , Jinlan Fu , Xiaoyu Shen

With the rapid advancement of deep learning, particularly in the field of medical image analysis, an increasing number of Vision-Language Models (VLMs) are being widely applied to solve complex health and biomedical challenges. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Haiyang Yu , Siyang Yi , Ke Niu , Minghan Zhuo , Bin Li

Aligning Large Language Models (LLMs) with human preferences is crucial, but standard methods like Reinforcement Learning from Human Feedback (RLHF) are often complex and unstable. In this work, we propose a new, simpler approach that…

Machine Learning · Computer Science 2026-01-27 Saeed Najafi , Alona Fyshe

Human preference alignment can greatly enhance Multimodal Large Language Models (MLLMs), but collecting high-quality preference data is costly. A promising solution is the self-evolution strategy, where models are iteratively trained on…

Machine Learning · Computer Science 2024-12-23 Wentao Tan , Qiong Cao , Yibing Zhan , Chao Xue , Changxing Ding

How can Large Language Models (LLMs) be aligned with human intentions and values? A typical solution is to gather human preference on model outputs and finetune the LLMs accordingly while ensuring that updates do not deviate too far from a…

Computation and Language · Computer Science 2024-05-28 Hung Le , Quan Tran , Dung Nguyen , Kien Do , Saloni Mittal , Kelechi Ogueji , Svetha Venkatesh

Large Language Models (LLMs) acquire extensive knowledge and remarkable abilities from extensive text corpora, making them powerful tools for various applications. To make LLMs more usable, aligning them with human preferences is essential.…

Computation and Language · Computer Science 2024-10-21 Mozhi Zhang , Pengyu Wang , Chenkun Tan , Mianqiu Huang , Dong Zhang , Yaqian Zhou , Xipeng Qiu

While learning to align Large Language Models (LLMs) with human preferences has shown remarkable success, aligning these models to meet the diverse user preferences presents further challenges in preserving previous knowledge. This paper…

Artificial Intelligence · Computer Science 2024-10-01 Gihun Lee , Minchan Jeong , Yujin Kim , Hojung Jung , Jaehoon Oh , Sangmook Kim , Se-Young Yun

Biomedical text mining is becoming increasingly important as the number of biomedical documents rapidly grows. With the progress in natural language processing (NLP), extracting valuable information from biomedical literature has gained…

Computation and Language · Computer Science 2019-10-21 Jinhyuk Lee , Wonjin Yoon , Sungdong Kim , Donghyeon Kim , Sunkyu Kim , Chan Ho So , Jaewoo Kang

Large Language Models (LLMs) often suffer from performance degradation when faced with domain shifts, primarily due to catastrophic forgetting. In this work, we propose KILO (Knowledge-Instructed Learning for Continual Adaptation), a novel…

Computation and Language · Computer Science 2025-08-06 Iing Muttakhiroh , Thomas Fevens