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Large Language Models (LLMs) have demonstrated remarkable capabilities on general text; however, their proficiency in specialized scientific domains that require deep, interconnected knowledge remains largely uncharacterized. Metabolomics…

Computation and Language · Computer Science 2025-10-17 Yuxing Lu , Xukai Zhao , J. Ben Tamo , Micky C. Nnamdi , Rui Peng , Shuang Zeng , Xingyu Hu , Jinzhuo Wang , May D. Wang

Although large multimodal models (LMMs) have demonstrated remarkable capabilities in visual scene interpretation and reasoning, their capacity for complex and precise 3-dimensional spatial reasoning remains uncertain. Existing benchmarks…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Xingrui Wang , Wufei Ma , Tiezheng Zhang , Celso M de Melo , Jieneng Chen , Alan Yuille

The integration of AI-assisted biomedical image analysis into clinical practice demands AI-generated findings that are not only accurate but also interpretable to clinicians. However, existing biomedical AI models generally lack the ability…

Protein representation learning is critical for numerous biological tasks. Recently, large transformer-based protein language models (pLMs) pretrained on large scale protein sequences have demonstrated significant success in sequence-based…

Machine Learning · Computer Science 2025-08-12 Xuefeng Liu , Songhao Jiang , Chih-chan Tien , Jinbo Xu , Rick Stevens

Foundation models pretrained on large-scale datasets via self-supervised learning demonstrate exceptional versatility across various tasks. Due to the heterogeneity and hard-to-collect medical data, this approach is especially beneficial…

Computational Engineering, Finance, and Science · Computer Science 2024-03-05 Yanwu Yang , Chenfei Ye , Guinan Su , Ziyao Zhang , Zhikai Chang , Hairui Chen , Piu Chan , Yue Yu , Ting Ma

Face recognition is a crucial task in various multimedia applications such as security check, credential access and motion sensing games. However, the task is challenging when an input face is noisy (e.g. poor-condition RGB image) or lacks…

Computer Vision and Pattern Recognition · Computer Science 2021-12-09 Wenbin Teng , Chongyang Bai

Robust medical Machine Learning (ML) models have the potential to revolutionize healthcare by accelerating clinical research, improving workflows and outcomes, and producing novel insights or capabilities. Developing such ML models from…

Sleep is essential for maintaining human health and quality of life. Analyzing physiological signals during sleep is critical in assessing sleep quality and diagnosing sleep disorders. However, manual diagnoses by clinicians are…

Signal Processing · Electrical Eng. & Systems 2025-10-02 Cheol-Hui Lee , Hakseung Kim , Byung C. Yoon , Dong-Joo Kim

Foundational models are trained on extensive datasets to capture the general trends of a domain. However, in medical imaging, the scarcity of data makes pre-training for every domain, modality, or task challenging. Instead of building…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Mohammad Areeb Qazi , Munachiso S Nwadike , Ibrahim Almakky , Mohammad Yaqub , Numan Saeed

Medical time-series data captures the dynamic progression of patient conditions, playing a vital role in modern clinical decision support systems. However, real-world clinical data is highly heterogeneous and inconsistently formatted.…

Machine Learning · Computer Science 2026-04-01 Zhongheng Jiang , Yuechao Zhao , Donglin Xie , Chenxi Sun , Rongchen Lu , Silu Luo , Zisheng Liang , Shenda Hong

Background: Computational drug repurposing is a cost- and time-efficient approach that aims to identify new therapeutic targets or diseases (indications) of existing drugs/compounds. It is especially critical for emerging and/or orphan…

Quantitative Methods · Quantitative Biology 2023-04-26 Chunyu Ma , Zhihan Zhou , Han Liu , David Koslicki

Medical imaging often operates under limited labeled data, especially in rare disease and low resource clinical environments. Existing multimodal and meta learning approaches improve performance in these settings but lack a theoretical…

Machine Learning · Statistics 2025-12-18 Md Talha Mohsin , Ismail Abdulrashid

Large Language Models (LLMs) have recently demonstrated remarkable performance in general tasks across various fields. However, their effectiveness within specific domains such as drug development remains challenges. To solve these…

Artificial Intelligence · Computer Science 2024-10-16 Tengfei Ma , Xuan Lin , Tianle Li , Chaoyi Li , Long Chen , Peng Zhou , Xibao Cai , Xinyu Yang , Daojian Zeng , Dongsheng Cao , Xiangxiang Zeng

The rapid advancement of autonomous systems, including self-driving vehicles and drones, has intensified the need to forge true Spatial Intelligence from multi-modal onboard sensor data. While foundation models excel in single-modal…

Computer Vision and Pattern Recognition · Computer Science 2026-01-09 Song Wang , Lingdong Kong , Xiaolu Liu , Hao Shi , Wentong Li , Jianke Zhu , Steven C. H. Hoi

Supervised learning algorithms based on Convolutional Neural Networks have become the benchmark for medical image segmentation tasks, but their effectiveness heavily relies on a large amount of labeled data. However, annotating medical…

Image and Video Processing · Electrical Eng. & Systems 2023-11-20 Tao Wang , Yuanbin Chen , Xinlin Zhang , Yuanbo Zhou , Junlin Lan , Bizhe Bai , Tao Tan , Min Du , Qinquan Gao , Tong Tong

With recent achievements in tasks requiring context awareness, foundation models have been adopted to treat large-scale data from electronic health record (EHR) systems. However, previous clinical recommender systems based on foundation…

Artificial Intelligence · Computer Science 2023-02-02 Seunghyun Lee , Da Young Lee , Sujeong Im , Nan Hee Kim , Sung-Min Park

Knowledge graphs are powerful tools for representing and organising complex biomedical data. Several knowledge graph embedding algorithms have been proposed to learn from and complete knowledge graphs. However, a recent study demonstrates…

Evaluating large language models (LLM) in clinical scenarios is crucial to assessing their potential clinical utility. Existing benchmarks rely heavily on static question-answering, which does not accurately depict the complex, sequential…

Human-Computer Interaction · Computer Science 2025-05-27 Samuel Schmidgall , Rojin Ziaei , Carl Harris , Eduardo Reis , Jeffrey Jopling , Michael Moor

Federated learning enables collaborative model training across geographically distributed medical centers while preserving data privacy. However, domain shifts and heterogeneity in data often lead to a degradation in model performance.…

Foundational Models (FMs) are gaining increasing attention in the biomedical AI ecosystem due to their ability to represent and contextualize multimodal biomedical data. These capabilities make FMs a valuable tool for a variety of tasks,…