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Automatic integration of whole slide images (WSIs) and gene expression profiles has demonstrated substantial potential in precision clinical diagnosis and cancer progression studies. However, most existing studies focus on individual gene…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Junzhuo Liu , Xuemei Du , Daniel Reisenbuchler , Ye Chen , Markus Eckstein , Christian Matek , Friedrich Feuerhake , Dorit Merhof

Nuclei segmentation is one of the important tasks for whole slide image analysis in digital pathology. With the drastic advance of deep learning, recent deep networks have demonstrated successful performance of the nuclei segmentation task.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-23 Inwan Yoo , Donggeun Yoo , Kyunghyun Paeng

Accurate segmentation of different sub-regions of gliomas including peritumoral edema, necrotic core, enhancing and non-enhancing tumor core from multimodal MRI scans has important clinical relevance in diagnosis, prognosis and treatment of…

Computer Vision and Pattern Recognition · Computer Science 2018-12-05 Xue Feng , Nicholas Tustison , Craig Meyer

Image segmentation is a critical step in computational biomedical image analysis, typically evaluated using metrics like the Dice coefficient during training and validation. However, in clinical settings without manual annotations,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Sikha O K , Meritxell Riera-Marín , Adrian Galdran , Javier García Lopez , Julia Rodríguez-Comas , Gemma Piella , Miguel A. González Ballester

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Breast cancer is one of the common cancers that endanger the health of women globally. Accurate target lesion segmentation is essential for early clinical intervention and postoperative follow-up. Recently, many convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2024-01-23 Gongping Chen , Lu Zhou , Jianxun Zhang , Xiaotao Yin , Liang Cui , Yu Dai

Given a reference object of an unknown type in an image, human observers can effortlessly find the objects of the same category in another image and precisely tell their visual boundaries. Such visual cognition capability of humans seems…

Computer Vision and Pattern Recognition · Computer Science 2021-08-04 Lechao Cheng , Zunlei Feng , Xinchao Wang , Ya Jie Liu , Jie Lei , Mingli Song

In pathology, accurate and efficient analysis of Hematoxylin and Eosin (H\&E) slides is crucial for timely and effective cancer diagnosis. Although many deep learning solutions for nuclei instance segmentation and classification exist in…

Image and Video Processing · Electrical Eng. & Systems 2024-08-12 Cristian Tommasino , Cristiano Russo , Antonio Maria Rinaldi

Nuclei instance segmentation in hematoxylin and eosin (H&E)-stained images plays an important role in automated histological image analysis, with various applications in downstream tasks. While several machine learning and deep learning…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod

In the cancer diagnosis pipeline, digital pathology plays an instrumental role in the identification, staging, and grading of malignant areas on biopsy tissue specimens. High resolution histology images are subject to high variance in…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Vasileios Magoulianitis , Catherine A. Alexander , C. -C. Jay Kuo

Accurately segmenting brain tumors from MRI scans is important for developing effective treatment plans and improving patient outcomes. This study introduces a new implementation of the Columbia-University-Net (CU-Net) architecture for…

Computer Vision and Pattern Recognition · Computer Science 2024-06-21 Qimin Zhang , Weiwei Qi , Huili Zheng , Xinyu Shen

In this study, the main objective is to develop an algorithm capable of identifying and delineating tumor regions in breast ultrasound (BUS) and mammographic images. The technique employs two advanced deep learning architectures, namely…

Image and Video Processing · Electrical Eng. & Systems 2024-02-14 Mohsen Ahmadi , Masoumeh Farhadi Nia , Sara Asgarian , Kasra Danesh , Elyas Irankhah , Ahmad Gholizadeh Lonbar , Abbas Sharifi

With the rapid development of deep learning and computer vision technologies, medical image segmentation plays a crucial role in the early diagnosis of breast cancer. However, due to the characteristics of breast ultrasound images, such as…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Jiajun Ding , Beiyao Zhu , Wenjie Wang , Shurong Zhang , Dian Zhua , Zhao Liua

Cancer is an abnormal growth with potential to invade locally and metastasize to distant organs. Accurate auto-segmentation of the tumor and surrounding normal tissues is required for radiotherapy treatment plan optimization. Recent…

Image and Video Processing · Electrical Eng. & Systems 2025-07-31 Syed Haider Ali , Asrar Ahmad , Muhammad Ali , Asifullah Khan , Nadeem Shaukat

Cancer is one of the leading causes of death in the developed world. Cancer diagnosis is performed through the microscopic analysis of a sample of suspicious tissue. This process is time consuming and error prone, but Deep Learning models…

Image and Video Processing · Electrical Eng. & Systems 2022-03-04 Pedro Costa , Yongpan Fu , João Nunes , Aurélio Campilho , Jaime S. Cardoso

Ultrasound imaging is widely used in clinical practice due to its cost-effectiveness, mobility, and safety. However, current AI research often treats disease prediction and tissue segmentation as two separate tasks and their model requires…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Zhi Chen , Le Zhang

Segmenting curvilinear structures in medical images is essential for analyzing morphological patterns in clinical applications. Integrating topological properties, such as connectivity, improves segmentation accuracy and consistency.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Zhuangzhi Gao , Feixiang Zhou , He Zhao , Xiuju Chen , Xiaoxin Li , Qinkai Yu , Yitian Zhao , Alena Shantsila , Gregory Y. H. Lip , Eduard Shantsila , Yalin Zheng

Nuclei panoptic segmentation supports cancer diagnostics by integrating both semantic and instance segmentation of different cell types to analyze overall tissue structure and individual nuclei in histopathology images. Major challenges…

Image and Video Processing · Electrical Eng. & Systems 2026-01-26 Ming Kang , Fung Fung Ting , Raphaël C. -W. Phan , Zongyuan Ge , Chee-Ming Ting

Efficient and precise classification of histological cell nuclei is of utmost importance due to its potential applications in the field of medical image analysis. It would facilitate the medical practitioners to better understand and…

Computer Vision and Pattern Recognition · Computer Science 2019-11-19 S H Shabbeer Basha , Soumen Ghosh , Kancharagunta Kishan Babu , Shiv Ram Dubey , Viswanath Pulabaigari , Snehasis Mukherjee

MRI tumor segmentation remains a critical challenge in medical imaging, where volumetric analysis faces unique computational demands due to the complexity of 3D data. The spatially sequential arrangement of adjacent MRI slices provides…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Jiacheng Lu , Hui Ding , Shiyu Zhang , Guoping Huo