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Machine learning methods are increasingly applied in medical imaging, yet many reported improvements lack statistical robustness: recent works have highlighted that small but significant performance gains are highly likely to be false…

Machine Learning · Computer Science 2025-11-05 Thomas Sanchez , Pedro M. Gordaliza , Meritxell Bach Cuadra

Benchmarking competitions are central to the development of artificial intelligence (AI) in medical imaging, defining performance standards and shaping methodological progress. However, it remains unclear whether these benchmarks provide…

Machine learning (ML) systems for medical imaging have demonstrated remarkable diagnostic capabilities, but their susceptibility to biases poses significant risks, since biases may negatively impact generalization performance. In this…

Machine Learning · Computer Science 2025-04-29 Haroui Ma , Francesco Quinzan , Theresa Willem , Stefan Bauer

Performance uncertainty quantification is essential for reliable validation and eventual clinical translation of medical imaging artificial intelligence (AI). Confidence intervals (CIs) play a central role in this process by indicating how…

Medical imaging is spearheading the AI transformation of healthcare. Performance reporting is key to determine which methods should be translated into clinical practice. Frequently, broad conclusions are simply derived from mean performance…

Artificial intelligence (AI) systems accelerate medical workflows and improve diagnostic accuracy in healthcare, serving as second-opinion systems. However, the unpredictability of AI errors poses a significant challenge, particularly in…

AI models are increasingly deployed in live clinical environments where they must perform reliably across complex, high-stakes workflows that standard training and validation datasets were never designed to capture. Evaluating these systems…

Artificial Intelligence · Computer Science 2026-05-12 Prasanna Desikan , Harshit Rajgarhia , Shivali Dalmia , Ananya Mantravadi

State-of-the-Art (SOTA) claims pervade Artificial Intelligence (AI) and Machine Learning (ML) research. These claims rest on benchmark evaluations, where models are ranked by aggregate scores across tasks. Public benchmarks or leaderboards…

Machine Learning · Computer Science 2026-05-26 YongKyung Oh

When training powerful AI systems to perform complex tasks, it may be challenging to provide training signals which are robust to optimization. One concern is \textit{measurement tampering}, where the AI system manipulates multiple…

Machine Learning · Computer Science 2023-10-02 Fabien Roger , Ryan Greenblatt , Max Nadeau , Buck Shlegeris , Nate Thomas

AI-based image reconstruction models are increasingly deployed in clinical workflows to improve image quality from noisy data, such as low-dose X-rays or accelerated MRI scans. However, these models are typically evaluated using pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Matteo Wohlrapp , Niklas Bubeck , Daniel Rueckert , William Lotter

For safety, medical AI systems undergo thorough evaluations before deployment, validating their predictions against a ground truth which is assumed to be fixed and certain. However, this ground truth is often curated in the form of…

Artificial intelligence (AI) models trained using medical images for clinical tasks often exhibit bias in the form of disparities in performance between subgroups. Since not all sources of biases in real-world medical imaging data are…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Emma A. M. Stanley , Raissa Souza , Anthony Winder , Vedant Gulve , Kimberly Amador , Matthias Wilms , Nils D. Forkert

In recent years, AI systems in the medical domain have advanced significantly. However, despite outperforming humans, they are rarely used in practice since it is often not clear how they make their decisions. Optimal explanation and…

Human-Computer Interaction · Computer Science 2026-05-06 Julia Wagner , Tim Schlippe

Deep neural networks excel in medical imaging but remain prone to biases, leading to fairness gaps across demographic groups. We provide the first systematic exploration of Human-AI alignment and fairness in this domain. Our results show…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Haozhe Luo , Ziyu Zhou , Zixin Shu , Aurélie Pahud de Mortanges , Robert Berke , Mauricio Reyes

As industry reports claim agentic AI systems deliver double-digit productivity gains and multi-trillion dollar economic potential, the validity of these claims has become critical for investment decisions, regulatory policy, and responsible…

Computers and Society · Computer Science 2025-10-03 Kiana Jafari Meimandi , Gabriela Aránguiz-Dias , Grace Ra Kim , Lana Saadeddin , Allie Griffith , Mykel J. Kochenderfer

Recently, the research community of computerized medical imaging has started to discuss and address potential fairness issues that may emerge when developing and deploying AI systems for medical image analysis. This chapter covers some of…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Enzo Ferrante , Rodrigo Echeveste

The integration of artificial intelligence (AI) into medical diagnostic workflows requires robust and consistent evaluation methods to ensure reliability, clinical relevance, and the inherent variability in expert judgments. Traditional…

This study evaluates the effectiveness of Artificial Intelligence (AI) in mitigating medical overtreatment, a significant issue characterized by unnecessary interventions that inflate healthcare costs and pose risks to patients. We…

General Economics · Economics 2024-06-05 Ziyi Wang , Lijia Wei , Lian Xue

Comparing model performances on benchmark datasets is an integral part of measuring and driving progress in artificial intelligence. A model's performance on a benchmark dataset is commonly assessed based on a single or a small set of…

Artificial Intelligence · Computer Science 2021-11-09 Kathrin Blagec , Georg Dorffner , Milad Moradi , Matthias Samwald

The prevalence of machine learning in biomedical research is rapidly growing, yet the trustworthiness of such research is often overlooked. While some previous works have investigated the ability of adversarial attacks to degrade model…

Machine Learning · Statistics 2023-08-21 Matthew Rosenblatt , Javid Dadashkarimi , Dustin Scheinost
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