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Spatial transcriptomics is an emerging technology that aligns histopathology images with spatially resolved gene expression profiling. It holds the potential for understanding many diseases but faces significant bottlenecks such as…

Computer Vision and Pattern Recognition · Computer Science 2024-01-12 Gabriel Mejia , Paula Cárdenas , Daniela Ruiz , Angela Castillo , Pablo Arbeláez

Identifying genes that display spatial patterns is critical to investigating expression interactions within a spatial context and further dissecting biological understanding of complex mechanistic functionality. Despite the increase in…

Methodology · Statistics 2025-10-06 Mingcong Wu , Yang Li , Shuangge Ma , Mengyun Wu

The rapid development of spatial transcriptomics(ST) enables the measurement of gene expression at spatial resolution, making it possible to simultaneously profile the gene expression, spatial locations of spots, and the matched…

Artificial Intelligence · Computer Science 2024-06-19 Changxi Chi , Hang Shi , Qi Zhu , Daoqiang Zhang , Wei Shao

Extracting useful information from large data sets can be a daunting task. Topological methods for analyzing data sets provide a powerful technique for extracting such information. Persistent homology is a sophisticated tool for identifying…

Quantum Physics · Physics 2015-12-17 Seth Lloyd , Silvano Garnerone , Paolo Zanardi

The machinery of topological data analysis becomes increasingly popular in a broad range of machine learning tasks, ranging from anomaly detection and manifold learning to graph classification. Persistent homology is one of the key…

Topological data analysis involves the statistical characterization of the shape of data. Persistent homology is a primary tool of topological data analysis, which can be used to analyze topological features and perform statistical…

Methodology · Statistics 2023-03-01 Chul Moon , Nicole A. Lazar

Persistent homology is a topological feature used in a variety of applications such as generating features for data analysis and penalizing optimization problems. We develop an approach to accelerate persistent homology computations…

Algebraic Topology · Mathematics 2023-01-19 Yuan Luo , Bradley J. Nelson

We introduce topological methods for quantifying spatially heterogeneous dynamics, and use these tools to analyze particle-tracking data for a quasi-two-dimensional granular system of air-fluidized beads on approach to jamming. In…

Soft Condensed Matter · Physics 2007-08-30 A. R. Abate , D. J. Durian

The predictions of mean-field electrodynamics can now be probed using direct numerical simulations of random flows and magnetic fields. When modelling astrophysical MHD, it is important to verify that such simulations are in agreement with…

Data Analysis, Statistics and Probability · Physics 2018-09-12 Irina Makarenko , Paul Bushby , Andrew Fletcher , Robin Henderson , Nikolay Makarenko , Anvar Shukurov

Garside et al. use event history methods to analyze topological data. We provide additional background on persistent homology to contrast the hazard estimators used by Garside et al. with traditional approaches in topological data analysis.…

Statistics Theory · Mathematics 2022-05-18 Peter Bubenik

Many datasets can be viewed as a noisy sampling of an underlying space, and tools from topological data analysis can characterize this structure for the purpose of knowledge discovery. One such tool is persistent homology, which provides a…

Persistent homology is a popular and powerful tool for capturing topological features of data. Advances in algorithms for computing persistent homology have reduced the computation time drastically -- as long as the algorithm does not…

Computational Geometry · Computer Science 2013-10-03 Ulrich Bauer , Michael Kerber , Jan Reininghaus

Understanding the structure of high-dimensional data is fundamental to neuroscience and other data-intensive scientific fields. While persistent homology effectively identifies basic topological features such as "holes," it lacks the…

Algebraic Topology · Mathematics 2025-07-16 Ekaterina S. Ivshina , Galit Anikeeva , Ling Zhou

We use methods from computational algebraic topology to study functional brain networks, in which nodes represent brain regions and weighted edges encode the similarity of fMRI time series from each region. With these tools, which allow one…

Quantitative Methods · Quantitative Biology 2020-08-27 Bernadette J. Stolz , Tegan Emerson , Satu Nahkuri , Mason A. Porter , Heather A. Harrington

Persistent homology is a mathematical tool used for studying the shape of data by extracting its topological features. It has gained popularity in network science due to its applicability in various network mining problems, including…

Algebraic Topology · Mathematics 2023-06-21 Mehmet Emin Aktas , Thu Nguyen , Rakin Riza , Muhammad Ifte Islam , Esra Akbas

In this chapter, we discuss applications of topological data analysis (TDA) to spatial systems. We briefly review the recently proposed level-set construction of filtered simplicial complexes, and we then examine persistent homology in two…

Social and Information Networks · Computer Science 2021-04-06 Michelle Feng , Abigail Hickok , Mason A. Porter

Persistent (co)homology is a central construction in topological data analysis, where it is used to quantify prominence of features in data to produce stable descriptors suitable for downstream analysis. Persistence is challenging to…

Computational Geometry · Computer Science 2024-10-23 Arnur Nigmetov , Dmitriy Morozov

In this paper, we consider topological featurizations of data defined over simplicial complexes, like images and labeled graphs, obtained by convolving this data with various filters before computing persistence. Viewing a convolution…

Algebraic Topology · Mathematics 2024-01-26 Elchanan Solomon , Paul Bendich

Topological data analysis can extract effective information from higher-dimensional data. Its mathematical basis is persistent homology. The persistent homology can calculate topological features at different spatiotemporal scales of the…

Algebraic Topology · Mathematics 2023-09-29 Dinghua Shi , Zhifeng Chen , Chuang Ma , Guanrong Chen

Assume that a finite set of points is randomly sampled from a subspace of a metric space. Recent advances in computational topology have provided several approaches to recovering the geometric and topological properties of the underlying…

Algebraic Topology · Mathematics 2021-01-29 Peter Bubenik , Peter T. Kim