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Virtual cell models aim to enable in silico experimentation by predicting how cells respond to genetic, chemical, or cytokine perturbations from single-cell measurements. In practice, however, large-scale perturbation prediction remains…

Machine Learning · Computer Science 2026-03-20 Shuizhou Chen , Lang Yu , Kedu Jin , Songming Zhang , Hao Wu , Wenxuan Huang , Sheng Xu , Quan Qian , Qin Chen , Lei Bai , Siqi Sun , Zhangyang Gao

Last level cache management and core interconnection network play important roles in performance and power consumption in multicore system. Large scale chip multicore uses mesh interconnect widely due to scalability and simplicity of the…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-08-14 Navin Kumar , Aryabartta Sahu

In this project, we investigate the fluctuations in performance caused by changing the Instruction (I-cache) size and the Data (D-cache) size in the L1 cache. We employ the Gem5 framework to simulate a system with varying specifications on…

Performance · Computer Science 2019-11-27 Ramya Akula , Kartik Jain , Deep Jigar Kotecha

In this paper we investigate the problem of optimal cache placement under secrecy constraints in heterogeneous networks, where small-cell base stations are equipped with caches to reduce the overall backhaul load. For two models for…

Information Theory · Computer Science 2016-03-21 Frederic Gabry , Valerio Bioglio , Ingmar Land

Over the past two decades, the storage capacity and access bandwidth of main memory have improved tremendously, by 128x and 20x, respectively. These improvements are mainly due to the continuous technology scaling of DRAM (dynamic…

Hardware Architecture · Computer Science 2017-12-25 Kevin K. Chang

This paper introduces NVCache, an approach that uses a non-volatile main memory (NVMM) as a write cache to improve the write performance of legacy applications. We compare NVCache against file systems tailored for NVMM (Ext4-DAX and NOVA)…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-09-06 Rémi Dulong , Rafael Pires , Andreia Correia , Valerio Schiavoni , Pedro Ramalhete , Pascal Felber , Gaël Thomas

Powerful hardware services and software libraries are vital tools for quickly and affordably designing, testing, and executing quantum algorithms. A robust large-scale study of how the performance of these platforms scales with the number…

This paper focuses on data structures for multi-core reachability, which is a key component in model checking algorithms and other verification methods. A cornerstone of an efficient solution is the storage of visited states. In related…

Distributed, Parallel, and Cluster Computing · Computer Science 2010-05-06 Alfons Laarman , Jaco van de Pol , Michael Weber

Multi-agent LLM systems on edge devices face a memory management problem: device RAM is too small to hold every agent's KV cache simultaneously. On Apple M4 Pro with 10.2 GB of cache budget, only 3 agents fit at 8K context in FP16. A…

Machine Learning · Computer Science 2026-03-06 Yakov Pyotr Shkolnikov

Vision-language models (VLMs) show remarkable performance in multimodal tasks. However, excessively long multimodal inputs lead to oversized Key-Value (KV) caches, resulting in significant memory consumption and I/O bottlenecks. Previous KV…

Computation and Language · Computer Science 2025-01-28 Zunhai Su , Wang Shen , Linge Li , Zhe Chen , Hanyu Wei , Huangqi Yu , Kehong Yuan

Data processing frameworks such as Apache Beam and Apache Spark are used for a wide range of applications, from logs analysis to data preparation for DNN training. It is thus unsurprising that there has been a large amount of work on…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-11-07 Ubaid Ullah Hafeez , Martin Maas , Mustafa Uysal , Richard McDougall

With the rapid development of internet Router, the complexity of its mainboard has been growing dramatically. The high reliability requirement renders the number of testing cases increasing exponentially, which becomes the bottleneck that…

Software Engineering · Computer Science 2020-01-13 Hanxiao Zhang , Shouzhou Liu , Yan-Fu Li

This study characterizes GPU resilience in Delta, a large-scale AI system that consists of 1,056 A100 and H100 GPUs, with over 1,300 petaflops of peak throughput. We used 2.5 years of operational data (11.7 million GPU hours) on GPU errors.…

--- Portuguese version As falhas de software est\~ao com frequ\^encia associadas a acidentes com graves consequ\^encias econ\'omicas e/ou humanas, pelo que se torna imperioso investir na valida\c{c}\~ao do software, nomeadamente daquele que…

Software Engineering · Computer Science 2018-07-24 Patrícia Monteiro , João Lourenço , António Ravara

This paper shows that cache-based optimizations are often ineffective in cloud virtual machines (VMs) due to limited visibility into and control over provisioned caches. In public clouds, CPU caches can be partitioned or shared among VMs,…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-03 Mani Tofigh , Edward Guo , Weiwei Jia , Xiaoning Ding , Zirui Neil Zhao , Jianchen Shan

Large Language Models (LLMs) are increasingly deployed in complex multi-agent applications that rely on external function calls. This workload creates severe performance challenges for the KV Cache: spatial contention leads to the eviction…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-21 Zhuohang Bian , Feiyang Wu , Zhuoran Li , Teng Ma , Youwei Zhuo

The growing memory footprint of the Key-Value (KV) cache poses a severe scalability bottleneck for long-context Large Language Model (LLM) inference. While KV cache eviction has emerged as an effective solution by discarding less critical…

Computation and Language · Computer Science 2025-10-28 Jinhan Chen , Jianchun Liu , Hongli Xu , Xianjun Gao , Shilong Wang

Program implementation and simulation are essential for research in the field of quantum algorithms. However, complex and large-scale quantum algorithms can pose challenges for existing quantum programming languages and simulators. Here, we…

Quantum Physics · Physics 2023-03-14 Zhao-Yun Chen , Cheng Xue , Xi-Ning Zhuang , Tai-Ping Sun , Huan-Yu Liu , Ye Li , Yu-Chun Wu , Guo-Ping Guo

It is a general notion that, in transient stability simulations, reducing the number of algebraic variables for the differential-algebraic equations (DAE) can improve the simulation performance. Many simulation programs split algebraic…

Systems and Control · Electrical Eng. & Systems 2022-07-08 Hantao Cui

This paper presents a comprehensive analysis of performance trade offs between implementation choices for transaction runtime systems on persistent memory. We compare three implementations of transaction runtimes: undo logging, redo…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-04-04 Virendra Marathe , Achin Mishra , Amee Trivedi , Yihe Huang , Faisal Zaghloul , Sanidhya Kashyap , Margo Seltzer , Tim Harris , Steve Byan , Bill Bridge , Dave Dice